Abstract: A mold-clamping device includes a fixed mold plate including a fixed mold; a movable mold plate including a movable mold; a hydraulic cylinder allowing the movable mold plate to approach or be separated from the fixed mold plate; a hydraulic pressure supply source supplying a hydraulic fluid to the hydraulic cylinder; and a control unit performing driving control on the hydraulic pressure supply source. The control unit includes a flow rate decrease control unit for deceleration for decreasing a flow rate of the hydraulic fluid according to a deceleration gradient set in advance when a movement of the movable mold plate is decelerated according to the deceleration gradient, and a flow rate increase control unit for controlling the flow rate of the hydraulic fluid to increase when the flow rate of the hydraulic fluid is decreased according to the deceleration gradient by the flow rate decrease control unit.

Abstract: A hydraulic supply device of an injection molding machine is provided with: a first main hydraulic power source including a first main hydraulic pump having a variable capacity and driven by a first constant rotational speed motor, and a first main discharge pipe through which working oil flows; an auxiliary hydraulic power source including an auxiliary hydraulic pump driven by a servo motor and operated at a specific capacity, an auxiliary discharge pipe through which the working oil flows, and a check valve that regulates the inflow of working oil to the auxiliary hydraulic pump; a hydraulic control unit that controls the first main hydraulic power source and the auxiliary hydraulic power source; a junction pipe at which the first main discharge pipe and the auxiliary discharge pipe join; and a switching unit that switches the supply/non-supply of working oil for a hydraulic actuator.

Abstract: A hydraulic oil storage device and an injection molding device are provided with a connection box that partitions a storage region of a sub-tank into a first region that includes a flow channel opening portion for a coupling tube and a second region other than the first region, in which the connection box is provided with an internal region communication portion that brings the first region and the second region into communication, and causes a pressure loss equal to the pressure loss of the coupling tube, or a pressure loss greater than that pressure loss, and a return tube is connected to the sub-tank so that the flow channel outlet faces the first region.

Abstract: A mold-clamping device includes a fixed mold plate including a fixed mold; a movable mold plate including a movable mold; a hydraulic cylinder allowing the movable mold plate to approach or be separated from the fixed mold plate; a hydraulic pressure supply source supplying a hydraulic fluid to the hydraulic cylinder; and a control unit performing driving control on the hydraulic pressure supply source. The control unit includes a flow rate decrease control unit for deceleration for decreasing a flow rate of the hydraulic fluid according to a deceleration gradient set in advance when a movement of the movable mold plate is decelerated according to the deceleration gradient, and a flow rate increase control unit for controlling the flow rate of the hydraulic fluid to increase when the flow rate of the hydraulic fluid is decreased according to the deceleration gradient by the flow rate decrease control unit.

Abstract: A hydraulic supply device of an injection molding machine is provided with: a first main hydraulic power source including a first main hydraulic pump having a variable capacity and driven by a first constant rotational speed motor, and a first main discharge pipe through which working oil flows; an auxiliary hydraulic power source including an auxiliary hydraulic pump driven by a servo motor and operated at a specific capacity, an auxiliary discharge pipe through which the working oil flows, and a check valve that regulates the inflow of working oil to the auxiliary hydraulic pump; a hydraulic control unit that controls the first main hydraulic power source and the auxiliary hydraulic power source; a junction pipe at which the first main discharge pipe and the auxiliary discharge pipe join; and a switching unit that switches the supply/non-supply of working oil for a hydraulic actuator.

Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2?-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2?-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

Abstract: Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as antibacterial and as other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.

Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

Abstract: Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.

Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

Abstract: Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.

Abstract: Compositions and methods for modulating the activity of RNA are disclosed, In accordance with preferred embodiments, antisense compositions are prepared targeting reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.

Abstract: A generating system having a rotating type generator to interconnect a power system in order to output power of the generator to the power system comprises a generator, an exciting circuit and an excitation control section. It also comprises short-cycle stabilizing sections for outputting a short-cycle stabilizing signal for suppressing short-cycle power fluctuations according to at least one of an electric parameter and a mechanical parameter of the generator and a long-cycle stabilizing section for outputting a long-cycle stabilizing signal for suppressing long-cycle power fluctuations having a cycle time longer than short-cycle power fluctuations according to the mechanical parameter of the generator. The outputs of the short-cycle stabilizing sections and the long-cycle stabilizing section are sent to the excitation control section.

Abstract: Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligonucleotide is modified to include an aminooxy moiety.

Abstract: Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligonucleotide is modified to include an aminooxy moiety.

Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.