Patents by Inventor Mamoru Shimizu

Mamoru Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240026358
    Abstract: Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.
    Type: Application
    Filed: March 11, 2022
    Publication date: January 25, 2024
    Inventors: Prashant Monian, Chikdu Shakti Shivalila, Subramanian Marappan, Chandra Vargeese, Pachamuthu Kandasamy, Genliang Lu, Hui Yu, David Charles Donnell Butler, Luciano Henrique Apponi, Mamoru Shimizu, Stephany Michelle Standley, David John Boulay, Andrew Guzior Hoss, Jigar Desai, Jack David Godfrey, Hailin Yang, Naoki Iwamoto, Jayakanthan Kumarasamy, Anthony Lamattina, Tom Liantang Pu
  • Publication number: 20230392137
    Abstract: Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.
    Type: Application
    Filed: September 26, 2022
    Publication date: December 7, 2023
    Inventors: Prashant Monian, Chikdu Shakti Shivalila, Subramanian Marappan, Chandra Vargeese, Pachamuthu Kandasamy, Genliang Lu, Hui Yu, David Charles Donnell Butler, Luciano Henrique Apponi, Mamoru Shimizu, Stephany Michelle Standley, David John Boulay, Andrew Guzior Hoss, Jigar Desai, Jack David Godfrey, Hailin Yang, Naoki Iwamoto, Jayakanthan Kumarasamy, Anthony Lamattina, Tom Liantang Pu
  • Publication number: 20230348524
    Abstract: Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
    Type: Application
    Filed: March 17, 2023
    Publication date: November 2, 2023
    Inventors: Keith Andrew Bowman, Chandra Vargeese, David Charles Donnell Butler, Pachamuthu Kandasamy, Mohammed Rowshon Alam, Mamoru Shimizu, Stephany Michelle Standley, Vincent Aduda, Gopal Reddy Bommineni, Snehlata Tripathi, Ilia Korboukh
  • Publication number: 20230329201
    Abstract: Among other things, the present disclosure provides cells and non-human animals engineered to express an ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, the present disclosure provides cells and non-human animals engineered to express a human ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, non-human animals are genetically modified rodents such as mice, rat, etc. In some embodiments, non-human animals are mice. In some embodiments, the present disclosure provides technologies for assessing an agent comprising administering the agent to a cell or non-human animal engineered to express an ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, such a cell or non-human animal is engineered to express a human ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, an agent is a pharmaceutical agent. In some embodiments, an agent is or comprises an oligonucleotide.
    Type: Application
    Filed: August 23, 2021
    Publication date: October 19, 2023
    Inventors: Hailin Yang, Prashant Monian, Chikdu Shakti Shivalila, Subramanian Marappan, Chandra Vargeese, Pachamuthu Kandasamy, Genliang Lu, Hui Yu, David Charles Donnell Butler, Luciano Henrique Apponi, Mamoru Shimizu, Stephany Michelle Standley, David John Boulay, Jack David Godfrey, Naoki Iwanmoto
  • Publication number: 20230295619
    Abstract: Among other things, the present disclosure provides oligonucleotides, compositions, and methods for preventing and/ or treating various conditions, disorders or diseases. In some embodiments, provided technologies comprise nucleobase modifications, sugar modifications, intemucleotidic linkage modifications and/or patterns thereof, and have improved properties, activities and/or selectivities. In some embodiments, provided technologies target MAPT. In some embodiments, the present disclosure provides MAPT oligonucleotides, compositions and methods for preventing and/or treating MAPT-associated conditions, disorders or diseases, such as Alzheimer’s Disease (AD) or Frontotemporal Dementia (FTD).
    Type: Application
    Filed: February 26, 2021
    Publication date: September 21, 2023
    Inventors: Abbie Madeline Maguire, Priyanka Shiva Prakasha, Naoki Iwamoto, Kenneth Allan Longo, Chandra Vargeese, Kevin Kim, Elena Dale, Pachamuthu Kandasamy, Mamoru Shimizu
  • Patent number: 11718638
    Abstract: The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: August 8, 2023
    Assignee: WAVE LIFE SCIENCES LTD.
    Inventors: David Charles Donnell Butler, Christopher P. Hencken, Naoki Iwamoto, Pachamuthu Kandasamy, Alvaro Andres Lanao, Genliang Lu, Mamoru Shimizu, Sethumadhavan Divakaramenon, Chandra Vargeese, Gopal Reddy Bommineni, Subramanian Marappan
  • Publication number: 20230220384
    Abstract: Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.
    Type: Application
    Filed: October 6, 2020
    Publication date: July 13, 2023
    Inventors: Prashant Monian, Chikdu Shakti Shivalila, Subramanian Marappan, Chandra Vargeese, Pachamuthu Kandasamy, Genliang Lu, Hui Yu, David Charles Donnell Butler, Luciano Henrique Apponi, Mamoru Shimizu, Stephany Michelle Standley, David John Boulay, Andrew Guzior Hoss, Jigar Desai, Jack David Godfrey, Hailin Yang, Naoki Iwamoto
  • Publication number: 20230203087
    Abstract: The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified oligonucleotides. In some embodiments, the present disclosure provides chirally controlled oligonucleotide compositions and methods for their preparation and uses.
    Type: Application
    Filed: May 24, 2021
    Publication date: June 29, 2023
    Inventors: Pachamuthu Kandasamy, Jayakanthan Kumarasamy, Chandra Vargeese, Subramanian Marappan, Gopal Reddy Bommineni, Mamoru Shimizu, Naoki Iwamoto, Stephany Michelle Standley, Yuanjing Liu, Amy Jada Andreucci, Genliang Lu, Onanong Chivatakarn, Akbar Husain Khan
  • Publication number: 20230089442
    Abstract: Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
    Type: Application
    Filed: March 19, 2020
    Publication date: March 23, 2023
    Inventors: Pachamuthu Kandasamy, Mamoru Shimizu, David Charles Donnell Butler, Jayakanthan Kumarasamy, Gopal Reddy Bommineni, Mohammed Rowshon Alam, Sethumadhavan Divakaramenon, Bijay Tilak Bhattarai, Chandra Vargeese, Keith Andrew Bowman, Stephany Michelle Standley
  • Patent number: 11608355
    Abstract: Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: March 21, 2023
    Assignee: WAVE LIFE SCIENCES LTD.
    Inventors: Keith Andrew Bowman, Chandra Vargeese, David Charles Donnell Butler, Pachamuthu Kandasamy, Mohammed Rowshon Alam, Mamoru Shimizu, Stephany Michelle Standley, Vincent Aduda, Gopal Reddy Bommineni, Snehlata Tripathi, Ilia Korboukh
  • Publication number: 20220356204
    Abstract: The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.
    Type: Application
    Filed: June 21, 2018
    Publication date: November 10, 2022
    Inventors: David Charles Donnell Butler, Christopher P. Hencken, Naoki Iwamoto, Pachamuthu Kandasamy, Alvaro Andres Lanao, Genliang Lu, Mamoru Shimizu, Sethumadhavan Divakaramenon, Chandra Vargeese, Gopal Reddy Bommineni, Subramanian Marappan
  • Publication number: 20220307019
    Abstract: A double-stranded nucleic acid complex is a double-stranded nucleic acid complex including a first nucleic acid strand and a second nucleic acid strand bonded to each other, the second nucleic acid strand including a complementary region having a base sequence complementary to the first nucleic acid strand; the first nucleic acid strand including natural nucleosides and non-natural nucleosides; some of the nucleosides in at least one nucleic acid strand selected from the group consisting of the first nucleic acid strand and the second nucleic acid strand being bonded together by bonds including asymmetric phosphorus atoms; and absolute configurations of the asymmetric phosphorus atoms being regulated.
    Type: Application
    Filed: March 25, 2020
    Publication date: September 29, 2022
    Applicants: National University Corporation Tokyo Medical and Dental University, Wave Life Sciences Ltd
    Inventors: Takanori YOKOTA, Takeshi WADA, Mamoru SHIMIZU
  • Publication number: 20220306573
    Abstract: Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods of use thereof. In some embodiments, the present disclosure provides technologies useful for reducing levels of transcripts. In some embodiments, the present disclosure provides technologies useful for modulating transcript splicing. In some embodiments, provided technologies can alter splicing of a dystrophin (DMD) transcript. In some embodiments, the present disclosure provides methods for treating diseases, such as Duchenne muscular dystrophy, Becker's muscular dystrophy, etc.
    Type: Application
    Filed: April 11, 2019
    Publication date: September 29, 2022
    Inventors: Jason Jingxin Zhang, Chandra Vargeese, Naoki Iwamoto, Chikdu Shakti Shivalila, Nayantara Kothari, Ann Fiegen Durbin, Selvi Ramasamy, Pachamuthu Kandasamy, Jayakanthan Kumarasamy, Gopal Reddy Bommineni, Subramanian Marappan, Sethumadhavan Divakaramenon, David Charles Donnell Butler, Genliang Lu, Hailin Yang, Mamoru Shimizu, Prashant Monian
  • Publication number: 20220186217
    Abstract: Among other things, the present disclosure provides designed DMD oligonucleotides, compositions, and methods of use thereof. In some embodiments, the present disclosure provides technologies useful for repairing mutant DMD transcripts by skipping exon 51, so that the transcript can be translated into an internally truncated but at least partially functional Dystrophin protein variant. In some embodiments, the present disclosure provides technologies useful for modulating DMD transcript splicing. In some embodiments, provided technologies can alter splicing of a dystrophin (DMD) DMD transcript. In some embodiments, the present disclosure provides methods for treating diseases, such as muscular dystrophy, including but not limited to Duchenne muscular dystrophy, Becker's muscular dystrophy, etc.
    Type: Application
    Filed: December 6, 2019
    Publication date: June 16, 2022
    Inventors: Jason Jingxin Zhang, Chandra Vargeese, Naoki Iwamoto, Chikdu Shakti Shivalila, Nayantara Kothari, Ann Fiegen Durbin, Selvi Ramasamy, Pachamuthu Kandasamy, Jayakanthan Kumarasamy, Gopal Reddy Bommineni, Subramanian Marappan, Sethumadhavan Divakaramenon, David Charles Donnell Butler, Genliang Lu, Hailin Yang, Mamoru Shimizu, Prashant Monian, Khoa Ngoc Dang Luu
  • Publication number: 20220127301
    Abstract: To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (—NO2), a halogen atom, a cyano group (—CN), a group of formula (II) or (III), or both G1 and G2 taken together to form a group of formula (IV).
    Type: Application
    Filed: September 2, 2021
    Publication date: April 28, 2022
    Inventors: Mamoru Shimizu, Takeshi Wada
  • Publication number: 20220002389
    Abstract: The present inventors have conducted intensive studies on an antibody which controls HIV in an administration group with a high probability over a long period of time with one or several times of single-agent administration. As a result, the present inventors have surprisingly found that, when an SW-1C10 antibody, which is obtained by producing an antibody gene reported as 1C10 in silkworms, is singly administered only a few times, the viral load in the blood is suppressed to the detection limit or lower at an early stage in all of individuals to which the antibody has been administered, and moreover, the viral RNA load in the blood is maintained at the detection limit or lower for a long time of 12 weeks. Also, the yield of the antibody in silkworms is approximately several hundreds ?g per cocoon, or several ?g per 1 mg of cocoon, and studies to increase the productivity more than this level have not been conducted heretofore.
    Type: Application
    Filed: October 28, 2019
    Publication date: January 6, 2022
    Inventors: Masahiro TOMITA, Mamoru SHIMIZU, Shuzo MATSUSHITA, Takeo KUWATA, Masahiro MICHISHITA, Yasuhiro YASUTOMI, Tomotaka OKAMURA
  • Patent number: 11136346
    Abstract: To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (—NO2), a halogen atom, a cyano group (—CN), a group of formula (II) or (III), or both G1 and G2 taken together to form a group of formula (IV).
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: October 5, 2021
    Assignee: WAVE LIFE SCIENCES LTD.
    Inventors: Mamoru Shimizu, Takeshi Wada
  • Publication number: 20210254062
    Abstract: Among other things, the present disclosure provides designed DMD oligonucleotides, compositions, and methods of use GC thereof. In some embodiments, the present disclosure provides technologies useful for repairing mutant DMD transcripts by skipping exon 51 or exon 53, so that the transcript can be translated into an internally truncated but at least partially functional Dystrophin protein variant. In some embodiments, the present disclosure provides technologies useful for modulating DMD transcript splicing. In some embodiments, provided technologies can alter splicing of a dystrophin (DMD) DMD transcript. In some embodiments, the present disclosure provides methods for treating diseases, such as muscular dystrophy, including but not limited to Duchenne muscular dystrophy, Becker's muscular dystrophy, etc.
    Type: Application
    Filed: May 10, 2019
    Publication date: August 19, 2021
    Applicant: WAVE LIFE SCIENCES LTD.
    Inventors: Jason Jingxin Zhang, Chandra Vargeese, Naoki Iwamoto, Chikdu Shakti Shivalila, Nayantara Kothari, Ann Fiegen Durbin, Selvi Ramasamy, Pachamuthu Kandasamy, Jayakanthan Kumarasamy, Gopal Reddy Bommineni, Subramanian Marappan, Sethumadhavan Divakaramenon, David Charles Donnell Butler, Genliang Lu, Hailin Yang, Mamoru Shimizu, Prashant Monian
  • Publication number: 20200385420
    Abstract: To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (—NO2), a halogen atom, a cyano group (—CN), a group of formula (II) or (III), or both G1 and G2 taken together to form a group of formula (IV).
    Type: Application
    Filed: May 19, 2020
    Publication date: December 10, 2020
    Inventors: Mamoru Shimizu, Takeshi Wada
  • Publication number: 20200231620
    Abstract: Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
    Type: Application
    Filed: September 17, 2018
    Publication date: July 23, 2020
    Inventors: Keith Andrew Bowman, Chandra Vargeese, David Charles Donnell Butler, Pachamuthu Kandasamy, Mohammed Rowshon Alam, Mamoru Shimizu, Stephany Michelle Standley, Vincent Aduda, Gopal Reddy Bommineni, Snehlata Tripathi, Ilia Korboukh