Patents by Inventor Mamoun Ahmad Salim Ahram

Mamoun Ahmad Salim Ahram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification and identification of a protein complex containing b-cell lymphoma protein (BCL10)
    Patent number: 11879000
    Abstract: A method for isolating a protein complex comprising BCL10 and at least one, preferably all, of ROS1, LSD1, BTK, KU80, KU70, CUL4A, IMP3, thioredoxin, hTID1, DAP3, CDK1/CDC2, PRL1/PTP4A1 or NM23. Methods for using this complex to diagnose or prognose diseases including diabetes, obesity, cancer, neurodegenerative disease or inflammatory diseases associated with activation of NF-?B. Methods for distinguishing lean, obese and diabetic subjects based on expression of BCL10 and its ligands are also disclosed. The invention also pertains to pharmaceutical compositions comprising ligands for BCL10 or other components of this complex or agents such as siRNA or miRNA that regulate the expression of the protein components of this complex.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: January 23, 2024
    Assignees: National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz City for Science and Technology
    Inventors: Ayman Mahmoud Saleh, Mamoun Ahmad Salim Ahram, Amre Osman Nasr
  • PURIFICATION AND IDENTIFICATION OF A PROTEIN COMPLEX CONTAINING B-CELL LYMPHOMA PROTEIN (BCL10)
    Publication number: 20210148907
    Abstract: A method for isolated a protein complex comprising BCL10 and at least one, preferably all, of ROS1, LSD1, BTK, KU80, KU70, CUL4A, IMP3, thioredoxin, hTID1, DAP3, CDK1/CDC2, PRL1/PTP4A1 or NM23. Methods for using this complex to diagnose or prognose diseases including diabetes, obesity, cancer, neurodegenerative disease or inflammatory diseases associated with activation of NF-?B Methods for distinguishing lean, obese and diabetic subjects based on expression of BCL10 and its ligands are also disclosed. The invention also pertains to pharmaceutical compositions comprising ligands for BCL10 or other components of this complex or agents such as siRNA or miRNA that regulate the expression of the protein components of this complex.
    Type: Application
    Filed: November 15, 2019
    Publication date: May 20, 2021
    Applicants: National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz City for Science and Technology
    Inventors: Ayman Mahmoud Saleh, Mamoun Ahmad Salim Ahram, Amre Osman Nasr