Patents by Inventor Mamta CHABRIA

Mamta CHABRIA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fibronectin-Binding Peptides for Use in Tumor or Fibrosis Diagnosis and Therapy
    Publication number: 20230212228
    Abstract: The present invention relates to fibronectin-binding peptides according to the sequence FnI5BS-L1-FnI4BS-L2-FnI3BS-L3-FnI2BS which are useful in tumor or fibrosis diagnosis and therapy. Instant peptides show improved fibronectin-binding and biodistribution properties compared to the prior art. Furthermore, instant peptides may be conjugated to a payload and are useful in the treatment and/or prevention of diseases associated with pathological fibronectin accumulation, including cancer and fibrosis. Instant peptides are also useful in diagnosis of diseases associated with pathological fibronectin accumulation, including cancer and fibrosis.
    Type: Application
    Filed: October 5, 2022
    Publication date: July 6, 2023
    Inventors: Viola VOGEL, Mamta CHABRIA, Giulia VALPREDA, Belinda TRACHSEL, Martin BEHE
  • Fibronectin-binding peptides for use in tumor or fibrosis diagnosis and therapy
    Patent number: 11649268
    Abstract: The present invention is directed to a composition comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic agent, a nucleic acid encoding a fusion polypeptide comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic polypeptide agent as well as a corresponding recombinant vector and host cell comprising such a nucleic acid and preferably expressing said fusion polypeptide. The invention also relates to a kit of parts comprising at least one fibronectin binding polypeptide (FnBP), at least one diagnostic or therapeutic agent, and optionally one or more chemical agents for linking the fibronectin binding polypeptide (FnBP) to the diagnostic or therapeutic agent.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: May 16, 2023
    Assignees: ETH ZURICH, PAUL SCHERRER INSTITUT
    Inventors: Mamta Chabria, Alessandra Moscaroli, Simon Arnoldini, Samuel Hertig, Viola Vogel, Martin Behe, Roger Schibli
  • FIBRONECTIN-BINDING PEPTIDES FOR USE IN TUMOR OR FIBROSIS DIAGNOSIS AND THERAPY
    Publication number: 20200181211
    Abstract: The present invention is directed to a composition comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic agent, a nucleic acid encoding a fusion polypeptide comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic polypeptide agent as well as a corresponding recombinant vector and host cell comprising such a nucleic acid and preferably expressing said fusion polypeptide. The invention also relates to a kit of parts comprising at least one fibronectin binding polypeptide (FnBP), at least one diagnostic or therapeutic agent, and optionally one or more chemical agents for linking the fibronectin binding polypeptide (FnBP) to the diagnostic or therapeutic agent.
    Type: Application
    Filed: June 14, 2017
    Publication date: June 11, 2020
    Inventors: Mamta CHABRIA, Alessandra MOSCAROLI, Simon ARNOLDINI, Samuel HERTIG, Viola VOGEL, Martin BEHE, Roger SCHIBLI