Patents by Inventor Man Jeong Paik

Man Jeong Paik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nano-neurotoxicity bio-marker composition based on intracellular aggregates which are biomarkers of degenerative brain diseases
    Patent number: 11261475
    Abstract: A method of assessing neurotoxicity of nanoparticles, includes: preparing a tissue or cell sample of mammal exposed to the nanoparticles; analyzing at least one polyamine metabolite selected from the group consisting of putrescine, N1-acetylspermidine, N8-acetylspermidine, N1-acetylspermine and spermine in the sample; and comparing expression degree of the polyamine metabolite with that of a control.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: March 1, 2022
    Inventors: Tae Hwan Shin, Geetika Phukan, Man Jeong Paik, Hyeon-Seong Lee, Hyung-Jin Park, Da Yeon Lee, Gwang Lee
  • NANO-NEUROTOXICITY BIO-MARKER COMPOSITION BASED ON INTRACELLULAR AGGREGATES WHICH ARE BIO-MARKERS OF DEGENERATIVE BRAIN DISEASES
    Publication number: 20190194715
    Abstract: A method of assessing neurotoxicity of nanoparticles, includes: preparing a tissue or cell sample of mammal exposed to the nanoparticles; analyzing at least one polyamine metabolite selected from the group consisting of putrescine, N1-acetylspermidine, N8-acetylspermidine, N1-acetylspermine and spermine in the sample; and comparing expression degree of the polyamine metabolite with that of a control.
    Type: Application
    Filed: May 12, 2017
    Publication date: June 27, 2019
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Tae Hwan SHIN, Geetika PHUKAN, Man Jeong PAIK, Hyeon-Seong LEE, Hyung-Jin PARK, Da Yeon LEE, Gwang LEE
  • Biomarker for diagnosing toxicity of nanoparticles and method for evaluating toxicity of nanoparticles using the same
    Patent number: 9689019
    Abstract: Disclosed is a biomarker composition for diagnosing the toxicity of nanoparticles, which shows a change in expression by exposure to the nanoparticles, the biomarker composition comprising at least one gene selected from the group consisting of aldehyde dehydrogenase, glutamic-pyruvate transaminase, glutamate dehydrogenase, glutamicoxaloacetic transaminase, glutamic acid decarboxylase and glutamate-ammonia ligase, and to a method for evaluating the toxicity of nanoparticles using the same. The biomarker is a gene marker having a high correlation with the toxicity of nanoparticles, and the use of the biomarker can determine whether nanoparticles have toxicity, with high detection sensitivity. Also, the method is useful in monitoring or evaluating the toxicity of nanoparticles by analyzing factors having a high correlation with toxicity of nanoparticles.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: June 27, 2017
    Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Woo Young Shim, Duc Toan Nguyen, Gwang Lee, Man Jeong Paik, Jae Ho Kim, Sang Mi Hyun, Ki Ryung Choi, Sung Su Park, Jin Seok Kang, Jeom Soon Shim, Tae-Hwan Shin, Geetika Phukan