Abstract: Compositions and methods are provided for creating and promoting biallelic targeted modifications to genomes within cells and for producing non-human animals comprising the modified genomes. Also provided are compositions and methods for modifying a genome within a cell that is heterozygous for an allele to become homozygous for that allele. The methods make use of Cas proteins and two or more guide RNAs that target different locations within the same genomic target locus. Also provided are methods of identifying cells with modified genomes.

Abstract: Provided are a seed of new soybean cultivar SCEL-1, a plant body of the seed or a part of the plant body, and an extract obtained from the seed.

Abstract: Compositions and methods are provided for creating and promoting biallelic targeted modifications to genomes within cells and for producing non-human animals comprising the modified genomes. Also provided are compositions and methods for modifying a genome within a cell that is heterozygous for an allele to become homozygous for that allele. The methods make use of Cas proteins and two or more guide RNAs that target different locations within the same genomic target locus. Also provided are methods of identifying cells with modified genomes.

Abstract: A refrigerator may include a storage compartment, an inner door which comprises an opening having a size corresponding to a size of the storage compartment, a plurality of door guards, and an outer door which open and close the storage compartment, wherein the inner door comprises a control unit may control an internal environment of the storage compartment.

Abstract: A laser dicing device includes: a Gaussian laser beam emitter configured to emit a Gaussian laser beam having a Gaussian energy distribution; a laser beam modulator configured to modulate a shape of the emitted Gaussian laser beam by reducing intensity in a region surrounding a first line parallel with a laser dicing direction of the emitted Gaussian beam, the first line crossing a center of the Gaussian laser beam in a plan view; a focusing lens configured to focus a modulated Gaussian laser beam modulated by the laser beam modulator; and a substrate support configured that a substrate to be diced is seated on the support, wherein the focusing lens is configured to collect the modulated Gaussian laser beam inside the substrate seated on the substrate support.

Abstract: A multilayer electronic component include a multilayer capacitor including a capacitor body and first and second external electrodes disposed on ends of the capacitor body, respectively; an alumina chip including a chip body and first and second external terminals disposed on ends of the chip body, respectively, the first and second external terminals being in contact with the first and second external electrodes, respectively; a first plating layer covering the first external electrode and the first external terminal; and a second plating layer covering the second external electrode and the second external terminal. The first and second plating layers each include a nickel plating layer a tin plating layer disposed on the first external electrode and the first external terminal and on the second external electrode and the second external terminal, respectively.

Abstract: A semiconductor memory device includes a circuit chip including a first substrate, peripheral circuit elements which are defined on the first substrate and a first dielectric layer which covers the peripheral circuit elements, and having first pads which are coupled to the peripheral circuit elements, on one surface thereof; a memory chip including a second substrate which is disposed on a base dielectric layer, a memory cell array which is defined on the second substrate and a second dielectric layer which covers the memory cell array, and having second pads which are coupled with the first pads, on one surface thereof which is bonded with the one surface of the circuit chip; a contact passing through the base dielectric layer and the second dielectric layer; and one or more dummy contacts passing through the base dielectric layer and the second dielectric layer, and disposed around the contact.

Abstract: A solar power generation unit includes at least one optical fiber including a light output region including a light output window and a light guide region guiding a light wave to the light output region; a housing of a tube type, the housing having an inner space in which the at least one optical fiber is located; and a power generation part including a solar panel provided at least at a side of the inner space of the housing and configured to generate power in response to the light wave incident thereon from the light output region of the at least one optical fiber.

Abstract: The present invention relates to a process of compacting a microporous fat powder, notably a microporous fat powder that can suitably be used as an oil structuring agent. One aspect of the invention relates to a process for compacting a microporous fat powder, said process comprising: feeding the fat powder into the feed zone of an extruder having a forwarding screw and a barrel within which said screw is centrally positioned; rotating said forwarding screw to advance said fat powder feed through a compacting zone of the extruder where the barrel comprises a plurality of venting openings having a shorter dimension that exceeds the volume weighted average diameter of the fat powder feed and that is less than 10 mm; and expelling the compacted fat powder from the extruder; wherein the temperature of the fat powder during passage through the extruder is maintained below 40° C. and wherein the compaction factor achieved exceeds 1.

Abstract: Provided herein are compositions including the crystalline forms of (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide (“Compound A”), methods of making the crystalline forms, and methods of using the crystalline forms for the treatment of diseases, including, for example, cancer.

Abstract: When cold and in the non-coated state, a turbine blade includes an aerodynamic profile that is substantially identical to a nominal profile determined by the Cartesian coordinates X, Y, Zadim given in Table 1, in which the coordinate Zadim is the quotient D/H where D is the distance of the point under consideration from a first reference plane P0 situated at the base of the nominal profile, and H is the height of said profile measured from the first reference plane to a second reference plane P1. The measurements D and H are taken radially relative to the axis of the turbine, while the X coordinate is measured in the axial direction of the turbine.

Abstract: An isolation structure for active devices is provided. In some embodiments, the isolation structure is used in a transistor. The transistor includes a substrate having a first doping type. The transistor also includes a channel layer positioned over the substrate and comprising a first section and a second section. The transistor further includes an active layer positioned over the channel layer. The isolation structure includes a horizontal segment, a first vertical segment, and a second vertical segment. The horizontal segment is arranged below the second section of the channel layer and continuously extends between the first vertical segment and the second vertical segment. The isolation structure has a second doping type that is different than the first doping type.

Abstract: The hand-held cleaner includes a body, and a cyclone dust collecting apparatus detachably mounted in the body. The cyclone dust collecting apparatus includes a pre-motor filter unit having a filter grill and a filter member, a dust collecting bin having one end to which the pre-motor filter unit is coupled and the other end opposite to the one end in which an cyclone inlet is formed, and a cyclone bin disposed in the dust collecting bin and having a spiral flow path-guide member integrally formed therein. A moving path of air drawn into the cyclone inlet is maintained in the same direction until the air is discharged through the pre-motor filter unit via the cyclone bin.

Abstract: A multiple fiber push-on (MPO) optical connector is provided having a ferrule configured to house multiple optical fibers and including a stepped portion extending from at least one pair of opposing exterior surfaces of the ferrule. A one-piece housing-backpost is provided having a distal end in a connection direction and a proximal end in a cable direction. The one-piece housing-backpost is configured to receive a ferrule spring and the ferrule from the distal end. The housing-backpost includes at least one resiliently-deformable ferrule-retaining protrusion extending from a sidewall to engage a corresponding stepped portion of the ferrule. The resiliently-deformable ferrule-retaining protrusion is configured to deform towards the housing-backpost interior sidewall as the ferrule is inserted from the distal end and to extend outward against the stepped portion of the ferrule when the ferrule is seated in the housing-backpost to maintain the ferrule in the housing-backpost.

Abstract: Systems and methods are described for manufacturing an adhesive tape. An example method includes: providing a plurality of adhesive webs, wherein each web includes a hot melt adhesive adhered to a backing material; providing a fabric web having a fabric material; guiding a first adhesive web from the plurality of adhesive webs into a first position proximate a first side of the fabric web; guiding a second adhesive web from the plurality of adhesive webs into a second position proximate a second side of the fabric web; applying heat and pressure to form a web of the baffle tape in which the first adhesive web is bonded to the first side of the fabric web and the second adhesive web is bonded to the second side of the fabric web; and rewinding the web of the baffle tape into a roll.

Abstract: The present disclosure provides a block coupler for connecting block to block for septic tank and water treatment facility. The block coupler comprises a body having a flow path therein; an inflow part having an inflow hole formed on one side of the longitudinal ends of the body so as to communicate with the flow path; an outflow part having an outflow hole formed on the other side of the longitudinal ends of the body having the inflow part so as to communicate with the flow path; and a connecting part provided at the outer end of the body having the inflow part so as to prevent the body coupled to the block from being separated.

Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

Abstract: A high throughput satellite (HTS) and a method of operating the HTS for relaying data between a low earth orbit (LEO) satellite and a target ground station, where the HTS provides spot beams for a spot beam coverage area. The method of operating the HTS includes: determining an estimated trajectory of an orbiting LEO satellite; assigning a plurality of assigned spot beams having a matching color re-use polarization; and transmitting assignments of the plurality of assigned spot beams to the high throughput satellite to cause the high throughput satellite to maintain the inter-satellite link via a first spot beam and one or more assigned subsequent spot beams having the matching color re-use polarization.

Abstract: This invention relates to a lyocell material for a cigarette filter and a method of manufacturing the same, wherein the lyocell material which is biodegradable and eco-friendly can be manufactured by crimping lyocell multifilaments to thus obtain a crimped tow.

Abstract: The present disclosure describes a system, method, and computer program for real-time and computationally efficient calculation of a recommended value range for a quote variable, such as price, discount, volume, or closing time. The system uses the highest-density interval (HDI) of probability density function (PDF) as a recommended or suggested value range for a quote variable. PDFs for the quote variable are precomputed for groups of related inputs, and each PDF is summarized as an array of discrete points. A dimension reduction technique is applied to the PDF inputs in both the training and real-time (non-training) phases to reduce the number of possible combinations of PDFs. During a quote-creation process, a PDF look-up table enables the system to efficiently identify an applicable PDF from the group of precomputed PDFs based on reduced input values.