Abstract: Provided are a compound of formula (I) that inhibit the activity of PARP7, a stereoisomer thereof, a deuterated derivative thereof, or a pharmaceutically acceptable salt thereof, an intermediate to prepare the compound, a process to prepare the compound, a composition comprising the same, and the methods of using the same.

Abstract: An optical fiber includes a core region having a longitudinal axis. A cladding region surrounds the core region. The core region and cladding region are configured to support and guide the propagation of signal light in a fundamental transverse mode in the core region in the directions of the axis. The fiber has a bend-induced gradient of its equivalent index of refraction indicative of a loss in guidance of the mode. At least a portion of cladding region has a graded index of refraction opposite the bend-induced gradient. The cladding region is configured to have a substantially flat equivalent index in response to a bend of the optical fiber.

Abstract: The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Abstract: The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Abstract: An optical fiber includes a core region having a longitudinal axis. A cladding region surrounds the core region. The core region and cladding region are configured to support and guide the propagation of signal light in a fundamental transverse mode in the core region in the directions of the axis. The fiber has a bend-induced gradient of its equivalent index of refraction indicative of a loss in guidance of the mode. At least a portion of cladding region has a graded index of refraction opposite the bend-induced gradient. The cladding region is configured to have a substantially flat equivalent index in response to a bend of the optical fiber.

Abstract: The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Abstract: The specification describes the production of optical fibers and optical fiber preforms using Chemical Powder Deposition (CPD). In this process a slurry of silica powders and dopant powders in a liquid carrier is prepared and the inside surface of a silica glass starter tube is coated with the slurry, then dried. The coating is then consolidated and the tube collapsed as in the conventional MCVD process. Multiple coatings, and coatings with varying compositions, can be used to produce any desired profile. In an alternative embodiment, doped silica glass of the desired final composition is prepared, and then pulverized to form the powder for the slurry. In both embodiments, the use of powders of known composition in the slurry allows direct control over the final glass composition, as compared with conventional processes in which the composition in the final glass is indirectly controlled by control of the thermodynamics of a vapor phase reaction.

Abstract: An in-line, distributed optical fiber filter comprises a core region with a raised refractive index (with respect to the surrounding cladding material) so as to allow for total internal reflection (TIR) of the desired transmission wavelength(s). One or more raised index features are formed within the cladding region and are configured so as to result in mode mixing between the cladding mode and core mode at determined wavelength(s) to be removed by filtering. The parameters associated with determining the proper core specifications and cladding specifications can be separately determined to provide for enhanced performance in terms of both filtering unwanted signals and propagation of desired communication signals.

Abstract: The specification describes methods for the manufacture of very large optical fiber preforms wherein the core material is produced by MCVD. Previous limitations on preform size inherent in having the MCVD starting tube as part of the preform process are eliminated by removing the MCVD starting tube material from the collapsed MCVD rod by etching or mechanical grinding. Doped overcladding tubes are used to provide the outer segments of the refractive index profile thus making most effective use of the MCVD produced glass and allowing the production of significantly larger MCVD preforms than previously possible.

Abstract: An improved MCVD process reduces a rippling structure in the refractive-index profile of a graded-index, multiple-mode optical fiber by incorporating N2O, CO, or NF3 gas in the gas stream during deposition of a soot sub-layer from which the optical fiber is formed. The soot sub-layer is sintered to form a glass sub-layer during deposition of a subsequent soot sub-layer. A dopant species is incorporated in each soot sub-layer during deposition. Fibers made from the doped glass sub-layers have a graded refractive-index profile that is near-parabolic in shape and that has significantly reduced rippling compared to profiles observed for fibers prepared conventionally.