Abstract: The server is a learning apparatus including a data acquisition unit and a learning unit. The data acquisition unit acquires profile data and a selected assistance level as learning data. The profile data indicates a profile related to a trainee before executing rehabilitation regarding rehabilitation executed using a walking training apparatus as a rehabilitation support system. The selected assistance level is an assistance level selected at the time of executing the rehabilitation. The learning unit learns to determine a recommended assistance level recommended to be selected when the trainee uses the rehabilitation support system based on the learning data. Further, the learning unit generates a trained model that receives the profile data and outputs the recommended assistance level based on the learning.

Abstract: Methods of treating subjects with cancer and screening for MDM2 inhibitors that may be effective cancer therapeutics are provided herein. The cancers that may be treated using MDM2 inhibitors using the methods described herein include those that are or may become resistant to treatment with tyrosine kinase inhibitors. Methods of treating subjects with cancers that have, or develop in response to treatment with tyrosine kinase inhibitors, elevated levels of MDM2, Mcl-1 or PP5 or decreased levels of Huwe1 or CAS using MDM2 inhibitors are provided herein. The MDM2 inhibitors may be effective at treating these cancers alone or in combination with a tyrosine kinase inhibitor regardless of p53 status (mutant or wild-type) of the cancer.

Abstract: A connection switch control part that, within a voltage change period where an applied voltage to an inverter can be changed by repeatedly and alternately switching to a serial state where a first power supply and a second power supply are connected in series to the inverter and to a parallel state where the first power supply and the second power supply are connected in parallel to the inverter, provides: a first period during which current of either one of the first power supply and the second power supply changes with an increasing trend, and current of the other one changes with a decreasing trend; and a second period during which current of one of the power supplies changes with a decreasing trend and current of the other power supply changes with an increasing trend.

Abstract: A control device of an electric power supply apparatus controls a voltage applied to an inverter to fall within a voltage range between a first voltage that is the voltage of one of a first electric power supply and a second electric power supply and a second voltage that is the sum of the voltage of the first electric power supply and the voltage of the second electric power supply, by alternately switching between a series state in which a current loop that connects the first electric power supply, the second electric power supply, and a reactor in series with the inverter is formed, and a parallel state in which the first electric power supply and the second electric power supply are connected in parallel with the inverter as an electric load.

Abstract: Methods of treating subjects with cancer and screening for MDM2 inhibitors that may be effective cancer therapeutics are provided herein. The cancers that may be treated using MDM2 inhibitors using the methods described herein include those that are or may become resistant to treatment with tyrosine kinase inhibitors. Methods of treating subjects with cancers that have, or develop in response to treatment with tyrosine kinase inhibitors, elevated levels of MDM2, Mcl-1 or PP5 or decreased levels of Huwe1 or CAS using MDM2 inhibitors are provided herein. The MDM2 inhibitors may be effective at treating these cancers alone or in combination with a tyrosine kinase inhibitor regardless of p53 status (mutant or wild-type) of the cancer.

Abstract: A connection switch control part that, within a voltage change period where an applied voltage to an inverter can be changed by repeatedly and alternately switching to a serial state where a first power supply and a second power supply are connected in series to the inverter and to a parallel state where the first power supply and the second power supply are connected in parallel to the inverter, provides: a first period during which current of either one of the first power supply and the second power supply changes with an increasing trend, and current of the other one changes with a decreasing trend; and a second period during which current of one of the power supplies changes with a decreasing trend and current of the other power supply changes with an increasing trend.

Abstract: A control device of an electric power supply apparatus controls a voltage applied to an inverter to fall within a voltage range between a first voltage that is the voltage of one of a first electric power supply and a second electric power supply and a second voltage that is the sum of the voltage of the first electric power supply and the voltage of the second electric power supply, by alternately switching between a series state in which a current loop that connects the first electric power supply, the second electric power supply, and a reactor in series with the inverter is formed, and a parallel state in which the first electric power supply and the second electric power supply are connected in parallel with the inverter as an electric load.

Abstract: A load drive apparatus includes: a converter which has two switching elements connected in series and through which a DC voltage, outputted from a battery, is converted into a DC voltage of a different level; an inverter through which the DC voltage, outputted from the converter, is converted into an AC voltage and the AC voltage is applied to a rotary inductive load; and a capacitor provided between the converter and the inverter so as to be in parallel to the converter and the inverter. One of the two switching elements, which constitutes part of a power supply path extending from the battery to the rotary inductive load, is a normally-on type semiconductor element. Accordingly, the present invention can provide the load drive apparatus that allows power, generated by a regenerative operation of the rotary inductive load, to be stored in the battery in a simple configuration even in the event of failure of a controller or a converter.

Abstract: The invention relates to the use of phospholipase C zeta in inducing or promoting the activation of oocytes, preferably human oocytes, nuclear transfer embryos, parthenogenic embryos, cross species embryos and during in vitro fertilization. The invention further relates to methods of detecting levels of expression of phospholipase c zeta in sperm as a means of detecting male infertility. The invention also relates to the use of phospholipase C zeta to treat male infertility. Still further the invention relates to the recombinant cells that are engineered to express phospholipase C zeta, preferably under inducible conditions. Also, the invention relates to antibodies specific to phospholipase C zeta, preferably human phospholipase C zeta.

Abstract: The present invention provides a method for parthenogenetic activation by injection and subsequent removal of a sperm into a mammalian cell, for example, an oocyte, an embryo, a blastomere, an inner cell mass cell, or a morulae cell.