Patents by Inventor Manabu Shirato

Manabu Shirato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives
    Patent number: 7939540
    Abstract: A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: May 10, 2011
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Kazuki Miyazaki, Kazutomi Kusano, Yasutaka Takase, Osamu Asano, Manabu Shirato, Hisashi Wakita, Naoto Ishii, Takao Saeki, Tomoko Saeki, legal representative, Mai Saeki, legal representative
  • Using Nonhuman Animal Model, Method of Measuring Transcription Activity Method of Measuring Cell Quantity and Method of Measuring Tumor Volume
    Publication number: 20080077999
    Abstract: In a nonhuman animal model that produces a secretory protein, which is obtained by transplanting secretory protein-expression vector-transfected cells into a nonhuman animal, an amount of the secretory protein is measured and, based on the amount of the secretory protein, transcriptional activity, number of the transplanted cells, and tumor volume is measured. Further, screening of a compound that affects a transcriptional activity, number of transplanted cells, or tumor volume is performed by using the nonhuman animal model to which a compound has been administered.
    Type: Application
    Filed: March 23, 2005
    Publication date: March 27, 2008
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Kiyoshi Okamoto, Takanori Kawamura, Makoto Asano, Daiya Shitakubo, Manabu Shirato, Makoto Asada
  • 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives
    Publication number: 20070299094
    Abstract: A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.
    Type: Application
    Filed: February 20, 2007
    Publication date: December 27, 2007
    Inventors: Kazuki Miyazaki, Kazutomi Kusano, Yasutaka Takase, Osamu Asano, Manabu Shirato, Hisashi Wakita, Naoto Ishii, Takao Saeki, Tomoko Saeki, Mai Saeki
  • Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
    Patent number: 7074801
    Abstract: The present invention discloses compounds and compositions of formula (I): having inhibitory activity on activation of STAT6, wherein X represents quinoline, isoquinoline, quinazoline or imidazopyridine; Y represents phenyl, piperazine, pyridine, thiophene, thiazole, oxathiazole or oxathiadiazole; and variables Z, n, R1, R2, R3 and R4 are as defined in the claims.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: July 11, 2006
    Assignee: Eisai Co., Ltd.
    Inventors: Ichiro Yoshida, Naoki Yoneda, Yoshiaki Ohashi, Shuichi Suzuki, Mitsuaki Miyamoto, Futoshi Miyazaki, Hidenori Seshimo, Junichi Kamata, Yasutaka Takase, Manabu Shirato, Daiya Shimokubo, Yoshinori Sakuma, Hiromitsu Yokohama
  • Cyclohexane derivatives
    Patent number: 5605907
    Abstract: To provide a novel cyclohexane derivative, a cyclohexane derivative is defined by the formula (I) or a pharmacologically acceptable salt thereof: ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen or lower alkyl; R.sup.3 represents optionally substituted aryl or optionally substituted heteroaryl; X represents oxygen or sulfur; and Y represents a group represented by the formula: ##STR2## or the like). The compound of the present invention is useful as a preventive and therapeutic agent for diseases against which a potassium channel opening action is efficacious.
    Type: Grant
    Filed: September 19, 1995
    Date of Patent: February 25, 1997
    Assignee: Eisai Co., Ltd.
    Inventors: Yasuhiro Kabasawa, Fumihiro Ozaki, Keiji Ishibashi, Takashi Hasegawa, Hitoshi Oinuma, Manabu Shirato, Katsuhiro Moriya, Toshiaki Ogawa, Satoshi Katayama, Shigeru Souda
  • Cyclohexane derivatives
    Patent number: 5478839
    Abstract: To provide a cyclohexane derivative defined by the formula (I) or a pharmacologically acceptable salt thereof: ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen or lower alkyl; R.sup.3 represents optionally substituted aryl or optionally substituted heteroaryl; X represents oxygen or sulfur; and Y represents a group represented by the formula: ##STR2## or the like). The compound of the present invention is useful as a preventive and therapeutic agent for diseases against which a potassium channel opening action is efficacious.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: December 26, 1995
    Assignee: Eisai Co., Ltd.
    Inventors: Yasuhiro Kabasawa, Fumihiro Ozaki, Keiji Ishibashi, Takashi Hasegawa, Hitoshi Oinuma, Manabu Shirato, Katsuhiro Moriya, Toshiaki Ogawa, Satoshi Katayama, Shigeru Souda