Patents by Inventor Manabu Soda

Manabu Soda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection method for novel ROS1 fusions
    Patent number: 9109259
    Abstract: Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: August 18, 2015
    Assignees: Japanese Foundation for Cancer Research, Educational Foundation Jichi Medical University
    Inventors: Kengo Takeuchi, Yuichi Ishikawa, Hiroyuki Mano, Manabu Soda, Eirin Sai
  • Identification, assessment, and therapy of cancers with innate or acquired resistance to ALK inhibitors
    Patent number: 9018230
    Abstract: Described herein are compositions, kits, and methods for determining whether subjects having cancer(s) positive for ALK mutations are likely to respond to treatment with an ALK inhibitor and/or whether a patient having such cancer(s) is likely to have a relatively slower disease progression. Further described are methods for prognosing a time course of disease in a subject having such cancer.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: April 28, 2015
    Assignee: Jichi Medical University
    Inventors: Hiroyuki Mano, Young L. Choi, Manabu Soda
  • Identification, Assessment, and Therapy of Cancers with Innate or Acquired Resistance to ALK Inhibitors
    Publication number: 20130203810
    Abstract: Described herein are compositions, kits, and methods for determining whether subjects having cancer(s) positive for ALK mutations are likely to respond to treatment with an ALK inhibitor and/or whether a patient having such cancer(s) is likely to have a relatively slower disease progression. Further described are methods for prognosing a time course of disease in a subject having such cancer.
    Type: Application
    Filed: February 4, 2011
    Publication date: August 8, 2013
    Inventors: Hiroyuki Mano, Young L. Choi, Manabu Soda
  • DETECTION METHOD FOR NOVEL ROS1 FUSIONS
    Publication number: 20130102006
    Abstract: Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.
    Type: Application
    Filed: June 22, 2011
    Publication date: April 25, 2013
    Applicants: Astellas Pharma Inc., Educational Foundation Jichi Medical University, Japanese Foundation For Cancer Research
    Inventors: Kengo Takeuchi, Yuichi Ishikawa, Hiroyuki Mano, Manabu Soda, Eirin Sai