Abstract: The present disclosure is directed to centralized de-identification of protected data associated with subjects in multiple modalities based on a hierarchal taxonomy of policies and handlers. In various embodiments, data set(s) associated with subject(s) may be received. Each of the data set(s) may contain data points associated with a respective subject. The data points associated with the respective subject may include multiple data types, at least some of which are usable to identify the respective subject. For each respective subject: a classification of each of the data points may be determined in accordance with a hierarchal taxonomy; based on the classifications, respective handlers for the data points may be identified; and each data point of the plurality of data points may be processed using a respective identified handler, thereby de-identifying the plurality of data points associated with the respective subject.