Patents by Inventor Manal M. Gabriel
Manal M. Gabriel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130228943Abstract: The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time.Type: ApplicationFiled: March 19, 2013Publication date: September 5, 2013Inventors: Yongxing Qiu, John Martin Lally, Manal M. Gabriel, Xinming Qian
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Publication number: 20120276278Abstract: The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.Type: ApplicationFiled: July 12, 2012Publication date: November 1, 2012Inventors: Yongxing Qiu, Lynn Cook Winterton, John Martin Lally, Nicholas Kotov, Manal M. Gabriel, Xinming Qian
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Patent number: 8172395Abstract: The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial pepetides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.Type: GrantFiled: November 25, 2003Date of Patent: May 8, 2012Assignee: Novartis AGInventors: Fiona Patricia Carney, Manal M. Gabriel, Carol Ann Morris, John Martin Lally
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Publication number: 20110114517Abstract: The present invention relates to a hydrogen peroxide solution for disinfecting contact lenses. The hydrogen peroxide solution contains an effective amount of a homopolymer or copolymer of vinylpyrrolidone to an increased residual hydrogen peroxide concentration when in the presence of a catalyst, thereby prolonging the effective life of the solution and providing greater comfort to the weather.Type: ApplicationFiled: November 17, 2010Publication date: May 19, 2011Inventors: Kasey Jon Minick, Manal M. Gabriel, Leroy Wainaina Muya, Walter Lee Nash, George Edward Minno
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Patent number: 7798639Abstract: The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.Type: GrantFiled: March 9, 2005Date of Patent: September 21, 2010Assignee: Novartis AGInventors: Lynn Cook Winterton, Yongxing Qiu, John Martin Lally, Manal M. Gabriel
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Publication number: 20080260804Abstract: The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.Type: ApplicationFiled: June 18, 2008Publication date: October 23, 2008Inventors: Carol Ann Morris, Manal M. Gabriel, Yongxing Qiu, Lynn Cook Winterton, John Martin Lally, Marcia Kay Ash, Fiona Patricia Carney, Courtney Flem Morgan
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Patent number: 7402318Abstract: The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.Type: GrantFiled: November 4, 2002Date of Patent: July 22, 2008Assignee: Novartis AGInventors: Carol Ann Morris, Manal M. Gabriel, Yongxing Qiu, Lynn Cook Winterton, John Martin Lally, Marcia Kay Ash, Fiona Patricia Carney, Courtney Flem Morgan
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Patent number: 6940580Abstract: The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.Type: GrantFiled: January 8, 2003Date of Patent: September 6, 2005Assignee: Novartis AGInventors: Lynn Cook Winterton, Yongxing Qiu, John Martin Lally, Manal M. Gabriel
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Publication number: 20040135967Abstract: The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial pepetides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.Type: ApplicationFiled: November 25, 2003Publication date: July 15, 2004Inventors: Fiona Patricia Carney, Manal M. Gabriel, Carol Ann Morris, John Martin Lally
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Publication number: 20030134132Abstract: The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.Type: ApplicationFiled: January 8, 2003Publication date: July 17, 2003Inventors: Lynn Cook Winterton, Yongxing Qiu, John Martin Lally, Manal M. Gabriel
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Publication number: 20030117579Abstract: The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.Type: ApplicationFiled: November 4, 2002Publication date: June 26, 2003Inventors: Carol Ann Morris, Manal M. Gabriel, Yongxing Qiu, Lynn Cook Winterton, John Martin Lally, Marcia Kay Ash, Fiona Patricia Carney, Courtney Flem Morgan