Patents by Inventor Mandana Manzari

Mandana Manzari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for the treatment of trail-resistant cancer
    Patent number: 11491206
    Abstract: Embodiments of the present disclosure relate generally to the treatment of cancer involving activation of the tumor necrosis factor-related apoptosis inducing ligand receptor (TRAILR) pathway. In particular, the present disclosure provides compositions and methods for the identification of genes conferring TRAIL resistance, and the development of rational drug combinations targeting these genes. The therapeutic drug combinations of the present disclosure function synergistically to sensitize cancer cells to TRAIL-resistant cancers.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: November 8, 2022
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Kris Wood, Mandana Manzari
  • TARGETED THERAPEUTIC AGENTS COMPRISING MULTIVALENT PROTEIN-BIOPOLYMER FUSIONS
    Publication number: 20190345228
    Abstract: Provided herein are fusion proteins including at least one binding polypeptide and at least one unstructured polypeptide. The fusion protein may further include at least one linker. Further provided are methods for determining the presence of a target in a sample, methods of treating a disease, methods of diagnosing a disease in a subject, and methods of determining the effectiveness of a treatment for a disease in a subject. The methods may include administering to the subject an effective amount of the fusion protein.
    Type: Application
    Filed: July 29, 2019
    Publication date: November 14, 2019
    Inventors: Ashutosh Chilkoti, Mandana Manzari, Mareva Fevre
  • Fibronectin type III domain-based fusion proteins
    Patent number: 10385115
    Abstract: Provided herein are fusion proteins including at least one binding polypeptide and at least one unstructured polypeptide. The fusion protein may further include at least one linker. Further provided are methods for determining the presence of a target in a sample, methods of treating a disease, methods of diagnosing a disease in a subject, and methods of determining the effectiveness of a treatment for a disease in a subject. The methods may include administering to the subject an effective amount of the fusion protein.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: August 20, 2019
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Mandana Manzari, Mareva Fevre
  • TARGETED THERAPEUTIC AGENTS COMPRISING MULTIVALENT PROTEIN-BIOPOLYMER FUSIONS
    Publication number: 20180258157
    Abstract: Provided herein are fusion proteins including at least one binding polypeptide and at least one unstructured polypeptide. The fusion protein may further include at least one linker. Further provided are methods for determining the presence of a target in a sample, methods of treating a disease, methods of diagnosing a disease in a subject, and methods of determining the effectiveness of a treatment for a disease in a subject. The methods may include administering to the subject an effective amount of the fusion protein.
    Type: Application
    Filed: March 25, 2016
    Publication date: September 13, 2018
    Inventors: Ashutosh Chilkoti, Mandana Manzari, Mareva Fevre