Abstract: The present invention relates to the field of pharmaceutical and nutraceutical formulations, and, more specifically, to effervescent formulations of ornithine aspartate as well as processes for their manufacture. Formulations of ornithine aspartate according to the present invention comprise a gas generating component as well as an acid component releasing carbon dioxide upon contact with water. The invention provides a simple process for the manufacture of such formulations that are chemically pure and stable and exhibit high levels of effervescence. The process comprises the following steps: —granulation of an ornithine aspartate-mix comprising ornithine aspartate and a gas generating component, thus yielding granules G, —mixing the components of a final mix comprising granules G and an acid component, thus yielding an effervescent formulation of ornithine aspartate.