Patents by Inventor Mandi J. Lopez
Mandi J. Lopez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240124843Abstract: Compositions and methods are described herein for transdifferentiation of multipotent stromal cells into cells that can express insulin.Type: ApplicationFiled: September 22, 2023Publication date: April 18, 2024Applicant: Board of Supervisors of Louisiana state University and Agriculture and Mechanical CollegeInventors: Mandi J. Lopez, Wei Duan
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Publication number: 20230338663Abstract: Provided are devices and methods for injecting viable transplant tissues into a subject. The device includes a fluid exchange chamber having a funneled portion connected to a pre-injection tube. The chamber includes fluid transfer holes and is disposed in an outer shell having a central bore connecting a top inlet and a bottom outlet from which the pre-injection tube exits the shell. A plunger having a central channel and a tapered bottom is disposed in the central bore such that the tapered bottom mates the funneled bottom when depressed and a stylet plunger is disposed in the central channel of the plunger.Type: ApplicationFiled: April 21, 2023Publication date: October 26, 2023Inventors: Mandi J. Lopez, Dorin Boldor, Thomas Coreil, Khoivu Dinh Nguyen, Allison Zieschang, Stefano Anthony Dardano, Luz De Luna Lawes
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Patent number: 11788062Abstract: Compositions and methods are described herein for transdifferentiation of multipotent stromal cells into cells that can express insulin.Type: GrantFiled: October 4, 2017Date of Patent: October 17, 2023Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: Mandi J. Lopez, Wei Duan
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Publication number: 20190345453Abstract: Compositions and methods are described herein for transdifferentiation of multipotent stromal cells into cells that can express insulin.Type: ApplicationFiled: October 4, 2017Publication date: November 14, 2019Applicant: Board of Supervisors of Louisiana State University and Agriculture and Mechanical CollegeInventors: Mandi J. Lopez, Wei Duan
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Patent number: 9872760Abstract: An improved device provides a cost-effective, time-effective way to stably and reliably affix soft tissues (e.g., tendon or ligament) to the surface of anatomical structures with comparable or greater strength and stiffness (e.g., bone). The device does not require specialized procedures or tools. A single device applies both incremental tensioning and compression to the soft tissue being affixed. The device allows the user, typically a physician or veterinarian, to reliably manipulate, control, and maintain tissue tension. The device is versatile, and can accommodate attachment of soft tissues of different sizes and mechanical properties to bone or to other soft tissues. These features provide flexibility to human and veterinary health practitioners in a variety of specialized areas including orthopedics, joint stabilization, soft tissue repair, spinal surgery, and plastic surgery.Type: GrantFiled: April 7, 2016Date of Patent: January 23, 2018Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: Mandi J. Lopez
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Publication number: 20160296319Abstract: An improved device provides a cost-effective, time-effective way to stably and reliably affix soft tissues (e.g., tendon or ligament) to the surface of anatomical structures with comparable or greater strength and stiffness (e.g., bone). The device does not require specialized procedures or tools. A single device applies both incremental tensioning and compression to the soft tissue being affixed. The device allows the user, typically a physician or veterinarian, to reliably manipulate, control, and maintain tissue tension. The device is versatile, and can accommodate attachment of soft tissues of different sizes and mechanical properties to bone or to other soft tissues. These features provide flexibility to human and veterinary health practitioners in a variety of specialized areas including orthopedics, joint stabilization, soft tissue repair, spinal surgery, and plastic surgery.Type: ApplicationFiled: April 7, 2016Publication date: October 13, 2016Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: Mandi J. Lopez
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Patent number: 9044315Abstract: A soft tissue fixation device for use in ACL or CrCL reconstruction has a base member provided with a passageway extending perpendicularly from its top surface through its bottom surface. The passageway is sized to allow soft tissue to be inserted through the passageway. The fixation device also includes an affixing member attachable to the base member. The base member has a notched section in the top surface extending from the passageway to a first perimeter section of the base member sized to accommodate at least a portion of the graft. Either surgical grade tissue glue or at least one perpendicularly extending spike is used to secure the base member to the bone. The base member is also provided with a sleeve whose interior wall surfaces form a part of the passageway and is sized to be inserted into the bone opening. The affixing member is provided with a series of teeth members extending downward from its lower surface.Type: GrantFiled: December 3, 2013Date of Patent: June 2, 2015Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical CollegeInventors: Mandi J. Lopez, W. Todd Monroe
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Publication number: 20140236195Abstract: A soft tissue fixation device for use in ACL or CrCL reconstruction has a base member provided with a passageway extending perpendicularly from its top surface through its bottom surface. The passageway is sized to allow soft tissue to be inserted through the passageway. The fixation device also includes an affixing member attachable to the base member. The base member has a notched section in the top surface extending from the passageway to a first perimeter section of the base member sized to accommodate at least a portion of the graft. Either surgical grade tissue glue or at least one perpendicularly extending spike is used to secure the base member to the bone. The base member is also provided with a sleeve whose interior wall surfaces form a part of the passageway and is sized to be inserted into the bone opening. The affixing member is provided with a series of teeth members extending downward from its lower surface.Type: ApplicationFiled: December 3, 2013Publication date: August 21, 2014Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Mandi J. Lopez, W. Todd Monroe
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Patent number: 8603115Abstract: A soft tissue fixation device for use in ACL or CrCL, reconstruction has a base member provided with a passageway extending perpendicularly from its top surface through its bottom surface. The passageway is sized to allow soft tissue to be inserted through the passageway. The fixation device also includes an affixing member attachable to the base member. The base member has a notched section in the top surface extending from the passageway to a first perimeter section of the base member sized to accommodate at least a portion of the graft. Either surgical grade tissue glue or at least one perpendicularly extending spike is used to secure the base member to the bone. The base member is also provided with a sleeve whose interior wall surfaces form a part of the passageway and is sized to be inserted into the bone opening. The affixing member is provided with a series of teeth members extending downward from its lower surface.Type: GrantFiled: July 31, 2006Date of Patent: December 10, 2013Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical CollegeInventors: W. Todd Monroe, Mandi J. Lopez
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Patent number: 7337751Abstract: A goniometer (also sometimes referred to as an arthrometer, fleximeter, or pronometer) for measuring the range of motion of an animal knee includes an anchor platform to which an animal's upper leg (femur) may be affixed, and a mobile platform to which the animal's lower leg (shin and tibia) may be affixed so that the upper and lower leg are situated along a common axis. The mobile platform is preferably movable in two degrees of freedom (translational and rotational) about the anchor platform so that the relative motion of the platforms causes the upper and lower leg to move about the intermediate knee joint. A force transducer (such as a spring scale) and/or a torque transducer (such as a common torque wrench) may be used to obtain measurements of the laxity of the knee joint.Type: GrantFiled: July 29, 2004Date of Patent: March 4, 2008Assignee: Wisconsin Alumni Research FoundationInventors: Mandi J. Lopez, Orrin D. Lokken, Mark D. Markel, William W. D. Hagquist
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Publication number: 20080027441Abstract: A soft tissue fixation device for use in ACL or CrCL, reconstruction has a base member provided with a passageway extending perpendicularly from its top surface through its bottom surface. The passageway is sized to allow soft tissue to be inserted through the passageway. The fixation device also includes an affixing member attachable to the base member. The base member has a notched section in the top surface extending from the passageway to a first perimeter section of the base member sized to accommodate at least a portion of the graft. Either surgical grade tissue glue or at least one perpendicularly extending spike is used to secure the base member to the bone. The base member is also provided with a sleeve whose interior wall surfaces form a part of the passageway and is sized to be inserted into the bone opening. The affixing member is provided with a series of teeth members extending downward from its lower surface.Type: ApplicationFiled: July 31, 2006Publication date: January 31, 2008Inventors: MANDI J. LOPEZ, W. TODD MONROE