Patents by Inventor Mandi WONG

Mandi WONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTI-COPY REFERENCE ASSAY
    Publication number: 20210254181
    Abstract: A method, comprising amplifying a nucleic acid sequence of interest in a sample comprising genomic DNA of a subject; amplifying a reference nucleic acid sequence in the sample; quantifying the amplified sequence of interest relative to the amplified reference sequence; and determining a copy number of the sequence of interest from the relative quantified amplified sequence of interest. The reference sequence may have at least 80% sequence identity to at least one of SEQ ID NO:1-38, such as SEQ ID NO:1-13. Also disclosed are kits and compositions, each comprising a first probe which specifically hybridizes to at least a portion of at least one reference sequence. Also disclosed is a system configured to perform the above method.
    Type: Application
    Filed: April 20, 2021
    Publication date: August 19, 2021
    Inventors: David MERRILL, Pius BRZOSKA, Zheng LI, Wendy LIN, Wing LEE, Mandi WONG
  • Multi-copy reference assay
    Patent number: 11008621
    Abstract: A method, comprising amplifying a nucleic acid sequence of interest in a sample comprising genomic DNA of a subject; amplifying a reference nucleic acid sequence in the sample; quantifying the amplified sequence of interest relative to the amplified reference sequence; and determining a copy number of the sequence of interest from the relative quantified amplified sequence of interest. The reference sequence may have at least 80% sequence identity to at least one of SEQ ID NO:1-38, such as SEQ ID NO:1-13. Also disclosed are kits and compositions, each comprising a first probe which specifically hybridizes to at least a portion of at least one reference sequence. Also disclosed is a system configured to perform the above method.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: May 18, 2021
    Assignee: Life Technologies Corporation
    Inventors: David Merrill, Pius Brzoska, Zheng Li, Wendy Lin, Wing Lee, Mandi Wong
  • MULTI-COPY REFERENCE ASSAY
    Publication number: 20170096711
    Abstract: A method, comprising amplifying a nucleic acid sequence of interest in a sample comprising genomic DNA of a subject; amplifying a reference nucleic acid sequence in the sample; quantifying the amplified sequence of interest relative to the amplified reference sequence; and determining a copy number of the sequence of interest from the relative quantified amplified sequence of interest. The reference sequence may have at least 80% sequence identity to at least one of SEQ ID NO:1-38, such as SEQ ID NO:1-13. Also disclosed are kits and compositions, each comprising a first probe which specifically hybridizes to at least a portion of at least one reference sequence. Also disclosed is a system configured to perform the above method.
    Type: Application
    Filed: March 20, 2015
    Publication date: April 6, 2017
    Inventors: David MERRILL, Pius BRZOSKA, Zheng LI, Wendy LIN, Wing LEE, Mandi WONG