Patents by Inventor Mandy J. McGeachy

Mandy J. McGeachy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered cytokine- and chemokine-expressing strains and methods of use
    Patent number: 10160974
    Abstract: Recombinant nucleic acid constructs for expression of heterologous cytokines or chemokines in C. albicans, and genetically modified C. albicans strains comprising the recombinant nucleic acid constructs, are described. The recombinant nucleic acid molecules include a C. albicans gene promoter sequence, a nucleic acid sequence encoding a C. albicans secreted protein signal sequence and a heterologous open reading frame (ORF) of a cytokine or chemokine gene. Also described are a method of expressing a heterologous cytokine or chemokine protein in a subject, and a method of treating or inhibiting the development of candidiasis in a subject. These methods include administering a genetically modified C. albicans containing a recombinant nucleic acid construct for expression of a heterologous cytokine or chemokine. Exemplary cytokines or chemokines include IL8, IL17A, CXCL1, CXCL2 and CXCL5.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: December 25, 2018
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Sarah L. Gaffen, Mandy J. McGeachy, Anna R. Huppler, Aaron P. Mitchell
  • ENGINEERED CYTOKINE- AND CHEMOKINE-EXPRESSING CANDIDA ALBICANS STRAINS AND METHODS OF USE
    Publication number: 20170009245
    Abstract: Recombinant nucleic acid constructs for expression of heterologous cytokines or chemokines in C. albicans, and genetically modified C. albicans strains comprising the recombinant nucleic acid constructs, are described. The recombinant nucleic acid molecules include a C. albicans gene promoter sequence, a nucleic acid sequence encoding a C. albicans secreted protein signal sequence and a heterologous open reading frame (ORF) of a cytokine or chemokine gene. Also described are a method of expressing a heterologous cytokine or chemokine protein in a subject, and a method of treating or inhibiting the development of candidiasis in a subject. These methods include administering a genetically modified C. albicans containing a recombinant nucleic acid construct for expression of a heterologous cytokine or chemokine. Exemplary cytokines or chemokines include IL8, IL17A, CXCL1, CXCL2 and CXCL5.
    Type: Application
    Filed: February 10, 2015
    Publication date: January 12, 2017
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Sarah L. Gaffen, Mandy J. McGeachy, Anna R. Huppler, Aaron P. Mitchell