Abstract: Novel antibodies for the detection and/or treatment of a cancer (e.g., a pancreatic cancer or an ovarian cancer) are provided. In certain embodiments the antibodies bind a region of the MUC4 protein that does not comprise the central tandem repeat (TR) domain of MUC4. Certain antibodies bind to the MUC4 peptide fragment MUC4-?-N-Ter and/or to the MUC4 peptide fragment MUC4-?-C-Ter. Chimeric constructs comprising such antibodies are also provided.

Abstract: A method comprising the steps of receiving a signal indicative of a failure of a working connection in a mesh network having a headend node, a tailend node and an intermediate node, and having a protecting connection, and transmitting an activation message via the protecting connection from at least one of the headend node and the tailend node to the intermediate node for activating the protecting connection.

Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.

Abstract: In accordance with the present disclosure, a method of configuring a wavelength division multiplexed (WDM) network is presented. The WDM network includes circuits that carry optical signals, with each signal corresponding to a wavelength. The WDM network includes nodes, with links connecting the nodes to one another. Each circuit includes at least one link and at least one node. The method comprises assigning each of the circuits to an optical signal, based on first and second criteria, and configuring the nodes based on the assignment.

Abstract: A method for detecting the liveliness and synchronizing the control-plane and data-plane on protecting connections in a shared mesh network environment through methods for probing the protecting connection conditions by sending in-band messages; and synchronization of control plane and data plane by using LSP-ping messages on the protecting connections.

Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.

Abstract: Embodiments of the present invention provide systems, devices and methods for improving the efficient deployment and configuration of networking equipment within a network build-out. In certain embodiments of the invention, an iterative analysis of inter-node equipment placement and connectivity, and inter- and intra-node traffic flow is performed to identify a preferred deployment solution. This analysis of deployment optimization takes into account both configurations from a network node perspective as well as from a network system perspective. Deployment solutions are iteratively progressed and analyzed to determine a preferred solution based on both the cost of deployment and satisfaction of the network demands. In various embodiments of the invention, a baseline marker is generated from which the accuracy of the solution may be approximated that suggests to an engineer whether the deployment is approaching an optimal solution.

Abstract: A method comprising the steps of receiving a signal indicative of a failure of a working connection in a mesh network having a headend node, a tailend node and an intermediate node, and having a protecting connection, and transmitting an activation message via the protecting connection from at least one of the headend node and the tailend node to the intermediate node for activating the protecting connection.

Abstract: Embodiments of the present invention provide systems, devices and methods for improving the efficient deployment and configuration of networking equipment within a network build-out. In certain embodiments of the invention, an iterative analysis of inter-node equipment placement and connectivity, and inter- and intra-node traffic flow is performed to identify a preferred deployment solution. This analysis of deployment optimization takes into account both configurations from a network node perspective as well as from a network system perspective. Deployment solutions are iteratively progressed and analyzed to determine a preferred solution based on both the cost of deployment and satisfaction of the network demands. In various embodiments of the invention, a baseline marker is generated from which the accuracy of the solution may be approximated that suggests to an engineer whether the deployment is approaching an optimal solution.

Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.

Abstract: The present invention provides a system, apparatus and method for discovery of network elements, which are adjacent within the network data plane but may or may not be adjacent in the network control plane. In one embodiment of the present invention, digital network elements, with a plurality thereof having a lambda switching capability (hereinafter “LSC”) interface, is provided. A digital network element with an LSC interface originates and sends a local advertisement to its immediate control neighbor. Using this LSC originated advertisements; a neighboring network element may be discovered that is adjacent on the network data plane.

Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.

Abstract: In accordance with the present disclosure, a method of configuring a wavelength division multiplexed (WDM) network is presented. The WDM network includes circuits that carry optical signals, with each signal corresponding to a wavelength. The WDM network includes nodes, with links connecting the nodes to one another. Each circuit includes at least one link and at least one node. The method comprises assigning each of the circuits to an optical signal, based on first and second criteria, and configuring the nodes based on the assignment.

Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.

Abstract: The invention includes devices and methods for forming random arrays of magnetic particles, arrays formed using these devices and methods, and to methods of using the arrays. The invention provides an assembly (chip) with magnetic domains that produce localized magnetic fields capable of immobilizing magnetic particles such as commercially available magnetic beads. Probe or sensor molecules can be coupled to the beads, which are then dispersed on the assembly, forming a random order array. The arrays can be used for analyzing samples, targets, and/or the interaction between samples and targets. The invention finds particular use in processes such as high-throughput genotyping and other nucleic acid hybridization-based assays.

Abstract: Embodiments of the invention provide for utilizing an intelligent automated script to test software applications. According to one embodiment, testing a software application can comprise executing a test script for testing a plurality of versions of the software application. For example, executing the test script can comprise instantiating a first instance of the test script for testing the first version of the software application. The first version of the software application can be initiated and a temporary map of the first version of the software application can be built by the test script. The first version of the software application can be tested based on the temporary map. In some cases, a second instance of the test script can be instantiated for testing a second version of the software application. In such cases, the first and second versions of the application may be tested in parallel.

Abstract: Embodiments of the present invention provide systems, devices and methods for improving the efficient deployment and configuration of networking equipment within a network build-out. In certain embodiments of the invention, an iterative analysis of inter-node equipment placement and connectivity, and inter- and intra-node traffic flow is performed to identify a preferred deployment solution. This analysis of deployment optimization takes into account both configurations from a network node perspective as well as from a network system perspective. Deployment solutions are iteratively progressed and analyzed to determine a preferred solution based on both the cost of deployment and satisfaction of the network demands. In various embodiments of the invention, a baseline marker is generated from which the accuracy of the solution may be approximated that suggests to an engineer whether the deployment is approaching an optimal solution.

Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.

Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.

Abstract: The present invention provides a system, apparatus and method for discovery of network elements, which are adjacent within the network data plane but may or may not be adjacent in the network control plane. In one embodiment of the present invention, digital network elements, with a plurality thereof having a lambda switching capability (hereinafter “LSC”) interface, is provided. A digital network element with an LSC interface originates and sends a local advertisement to its immediate control neighbor. Using this LSC originated advertisements; a neighboring network element may be discovered that is adjacent on the network data plane.