Patents by Inventor Manfred Böhm
Manfred Böhm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20210348123Abstract: Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derided cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.Type: ApplicationFiled: June 3, 2021Publication date: November 11, 2021Inventors: Manfred Boehm, Guibin Chen, Mahendra Rao, Andre Larochelle
-
Patent number: 11072778Abstract: Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.Type: GrantFiled: August 19, 2019Date of Patent: July 27, 2021Assignee: THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICESInventors: Manfred Boehm, Guibin Chen, Mahendra Rao, Andre Larochelle
-
Publication number: 20200095544Abstract: Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.Type: ApplicationFiled: August 19, 2019Publication date: March 26, 2020Inventors: Manfred Boehm, Guibin Chen, Mahendra Rao, Andre Larochelle
-
Patent number: 10385313Abstract: Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.Type: GrantFiled: October 1, 2014Date of Patent: August 20, 2019Assignee: The USA, as represented by the Secretary, Department of Health and Human ServicesInventors: Manfred Boehm, Guibin Chen, Mahendra Rao, Andre Larochelle
-
Publication number: 20160222348Abstract: Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.Type: ApplicationFiled: October 1, 2014Publication date: August 4, 2016Inventors: Manfred BOEHM, Guibin CHEN, Mahendra RAO, Andre LAROCHELLE
-
Patent number: 8471207Abstract: In a method for the automatic inspection of a welding seam using heat flow thermography, a feature vector is established which represents a time course of a detected heat flow. The feature vector is used to determine, from a series of thermal images, a first characteristic thermal image, which corresponds to a minimum heat flow through an object to be examined, and a second characteristic thermal image, which corresponds to a maximum heat flow through the object, wherein a heat flow directly from an excitation source has already dissipated. A suitable thermal image is used from the series of thermal images to detect and evaluate the welding seam in relation to defects of various defect types, for each defect type, the characteristic thermal images being used as references to determine the respective suitable thermal image.Type: GrantFiled: July 3, 2008Date of Patent: June 25, 2013Inventors: Roman Louban, Christoph Döttinger, Peter Stolz, Manfred Böhm
-
Publication number: 20130109645Abstract: Disclosed are a method of treating or preventing a disorder in a mammal comprising administering to the mammal an adenosine receptor agonist or an adenosine receptor antagonist, either alone or in combination, in an amount effective to treat or prevent medial vascular or joint capsule calcification. Disclosed are methods of detecting or diagnosing a vascular or joint capsule calcification disorder, as well as a nucleic acid comprising a mutation in one or more exons of human NT5E selected from the group consisting of Exon 3, Exon 5, and Exon 9.Type: ApplicationFiled: March 30, 2011Publication date: May 2, 2013Applicant: The united States of America,as represented by Secretary,Dept.,of Health and Human ServicesInventors: William A. Gahl, Manfred Boehm, Cynthia St. Hilaire, Shira G. Ziegler, Thomas C. Markello
-
Publication number: 20100163732Abstract: In a method for the automatic inspection of a welding seam using heat flow thermography, a feature vector is established which represents a time course of a detected heat flow. The feature vector is used to determine, from a series of thermal images, a first characteristic thermal image, which corresponds to a minimum heat flow through an object to be examined, and a second characteristic thermal image, which corresponds to a maximum heat flow through the object, wherein a heat flow directly from an excitation source has already dissipated. A suitable thermal image is used from the series of thermal images to detect and evaluate the welding seam in relation to defects of various defect types, for each defect type, the characteristic thermal images being used as references to determine the respective suitable thermal image.Type: ApplicationFiled: July 3, 2008Publication date: July 1, 2010Applicant: Thermosensorik GmbHInventors: Roman Louban, Christoph Döttinger, Peter Stolz, Manfred Böhm
-
Patent number: 7414035Abstract: Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.Type: GrantFiled: May 12, 2005Date of Patent: August 19, 2008Assignee: The Regents of the University of MichiganInventors: Gary J Nabel, Elizabeth G. Nabel, Manfred Boehm
-
Publication number: 20070050648Abstract: Certain embodiments of the present invention provide for a system for communication between a controller and a power supply using a communication interface. In an embodiment, a communication system includes a power supply having one or more diagnostics. The communication system also includes a controller, configured for controlling the power supply and monitoring the one or more diagnostics of the power supply. In addition, the communication system includes a communication interface, configured to receive from the controller and send from the power supply one or more signals. The communication system also includes a load, configured to operate using the power provided by said power supply.Type: ApplicationFiled: August 26, 2005Publication date: March 1, 2007Inventors: Sabih Zaman, Olgun Kukrer, Manfred Boehm
-
Publication number: 20050203050Abstract: Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.Type: ApplicationFiled: May 12, 2005Publication date: September 15, 2005Inventors: Gary Nabel, Elizabeth Nabel, Manfred Boehm
-
Patent number: 6894154Abstract: Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.Type: GrantFiled: March 11, 2004Date of Patent: May 17, 2005Assignee: Regents of the University of MichiganInventors: Gary J. Nabel, Elizabeth G. Nabel, Manfred Boehm
-
Patent number: 6790478Abstract: In a ceramic hybrid substrate and a method for treating the surface of a ceramic hybrid substrate having ceramic surface areas and metallic surface areas, the ceramic surface areas are esterified.Type: GrantFiled: May 24, 2002Date of Patent: September 14, 2004Assignee: Robert Bosch GmbHInventors: Walter Roethlingshoefer, Manfred Boehm
-
Patent number: 6770473Abstract: Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.Type: GrantFiled: August 20, 1999Date of Patent: August 3, 2004Assignee: The Regents of the University of MichiganInventors: Gary J. Nabel, Elizabeth G. Nabel, Manfred Boehm
-
Publication number: 20040146982Abstract: Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.Type: ApplicationFiled: March 11, 2004Publication date: July 29, 2004Applicant: The Regents of the University of MichiganInventors: Gary J. Nabel, Elizabeth G. Nabel, Manfred Boehm
-
Patent number: 6246664Abstract: Digital signals are commonly transmitted using the single-carrier method or the multicarrier method, for example. Both methods use one carrier frequency per transmission channel or subchannel of predetermined bandwidth. According to the invention, at least two carrier frequencies (f1, f2, f3) are used to increase the transmission capacity of a channel. The distance between two carrier frequencies is less than the absolute value of a carrier frequency (f1, f2, f3) by a factor of, e.g., 500. The beat frequency resulting from the combination (ADD) of several carrier frequencies (f1, f2, f3) in a channel is negligible, particularly if the transmitted carrier frequencies (f1, f2, f3) are in phase at the start of oscillations. By the combination (ADD) of several carrier frequencies (f1, f2, f3), equal resulting carrier frequencies can be obtained for different bit streams (DATA1, DATA2, DATA3).Type: GrantFiled: April 17, 1998Date of Patent: June 12, 2001Assignee: AlcatelInventor: Manfred Böhm
-
Patent number: 5073748Abstract: A numerically-controlled driving system has a rate-of-change limiter that is applicable to positioning- and continuous-path-control systems as used in robots, machine tools, elevators, etc. When control signals are input, sudden variations in acceleration or velocity are damped, because the discrete control values calculated by a numerical control system are filtered by a pulse filter in accordance with the principle of discrete convolution.Type: GrantFiled: September 27, 1990Date of Patent: December 17, 1991Assignee: Siemens AktiengesellschaftInventor: Manfred Boehm
-
Patent number: 5070287Abstract: A numerical positioning control system renders possible clocked-synchronous acceleration, and deceleration operations for motorized driving systems (A). A specified target point (PO), which for example can be the end point of a path section, can be reached with a predetermined final velocity (V.sub.END) exactly at a calibration time (T) of the numerical control. At least two acceleration values (a.sub.1,a) are defined for the acceleration, and braking operation, whereby the time which is required for the entire acceleration operation is exactly an integral multiple of the calibration time (T) of the numerical control. To avoid sudden changes in acceleration, a rate-of-change limiter is implemented according to the principle of discrete convolution.Type: GrantFiled: September 27, 1990Date of Patent: December 3, 1991Assignee: Siemens AktiengesellschaftInventor: Manfred Boehm