Patents by Inventor Manfred Böhm

Manfred Böhm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210348123
    Abstract: Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derided cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.
    Type: Application
    Filed: June 3, 2021
    Publication date: November 11, 2021
    Inventors: Manfred Boehm, Guibin Chen, Mahendra Rao, Andre Larochelle
  • Patent number: 11072778
    Abstract: Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: July 27, 2021
    Assignee: THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
    Inventors: Manfred Boehm, Guibin Chen, Mahendra Rao, Andre Larochelle
  • Publication number: 20200095544
    Abstract: Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 26, 2020
    Inventors: Manfred Boehm, Guibin Chen, Mahendra Rao, Andre Larochelle
  • Patent number: 10385313
    Abstract: Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: August 20, 2019
    Assignee: The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Manfred Boehm, Guibin Chen, Mahendra Rao, Andre Larochelle
  • Publication number: 20160222348
    Abstract: Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.
    Type: Application
    Filed: October 1, 2014
    Publication date: August 4, 2016
    Inventors: Manfred BOEHM, Guibin CHEN, Mahendra RAO, Andre LAROCHELLE
  • Patent number: 8471207
    Abstract: In a method for the automatic inspection of a welding seam using heat flow thermography, a feature vector is established which represents a time course of a detected heat flow. The feature vector is used to determine, from a series of thermal images, a first characteristic thermal image, which corresponds to a minimum heat flow through an object to be examined, and a second characteristic thermal image, which corresponds to a maximum heat flow through the object, wherein a heat flow directly from an excitation source has already dissipated. A suitable thermal image is used from the series of thermal images to detect and evaluate the welding seam in relation to defects of various defect types, for each defect type, the characteristic thermal images being used as references to determine the respective suitable thermal image.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: June 25, 2013
    Inventors: Roman Louban, Christoph Döttinger, Peter Stolz, Manfred Böhm
  • Publication number: 20130109645
    Abstract: Disclosed are a method of treating or preventing a disorder in a mammal comprising administering to the mammal an adenosine receptor agonist or an adenosine receptor antagonist, either alone or in combination, in an amount effective to treat or prevent medial vascular or joint capsule calcification. Disclosed are methods of detecting or diagnosing a vascular or joint capsule calcification disorder, as well as a nucleic acid comprising a mutation in one or more exons of human NT5E selected from the group consisting of Exon 3, Exon 5, and Exon 9.
    Type: Application
    Filed: March 30, 2011
    Publication date: May 2, 2013
    Applicant: The united States of America,as represented by Secretary,Dept.,of Health and Human Services
    Inventors: William A. Gahl, Manfred Boehm, Cynthia St. Hilaire, Shira G. Ziegler, Thomas C. Markello
  • Publication number: 20100163732
    Abstract: In a method for the automatic inspection of a welding seam using heat flow thermography, a feature vector is established which represents a time course of a detected heat flow. The feature vector is used to determine, from a series of thermal images, a first characteristic thermal image, which corresponds to a minimum heat flow through an object to be examined, and a second characteristic thermal image, which corresponds to a maximum heat flow through the object, wherein a heat flow directly from an excitation source has already dissipated. A suitable thermal image is used from the series of thermal images to detect and evaluate the welding seam in relation to defects of various defect types, for each defect type, the characteristic thermal images being used as references to determine the respective suitable thermal image.
    Type: Application
    Filed: July 3, 2008
    Publication date: July 1, 2010
    Applicant: Thermosensorik GmbH
    Inventors: Roman Louban, Christoph Döttinger, Peter Stolz, Manfred Böhm
  • Patent number: 7414035
    Abstract: Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: August 19, 2008
    Assignee: The Regents of the University of Michigan
    Inventors: Gary J Nabel, Elizabeth G. Nabel, Manfred Boehm
  • Publication number: 20070050648
    Abstract: Certain embodiments of the present invention provide for a system for communication between a controller and a power supply using a communication interface. In an embodiment, a communication system includes a power supply having one or more diagnostics. The communication system also includes a controller, configured for controlling the power supply and monitoring the one or more diagnostics of the power supply. In addition, the communication system includes a communication interface, configured to receive from the controller and send from the power supply one or more signals. The communication system also includes a load, configured to operate using the power provided by said power supply.
    Type: Application
    Filed: August 26, 2005
    Publication date: March 1, 2007
    Inventors: Sabih Zaman, Olgun Kukrer, Manfred Boehm
  • Publication number: 20050203050
    Abstract: Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.
    Type: Application
    Filed: May 12, 2005
    Publication date: September 15, 2005
    Inventors: Gary Nabel, Elizabeth Nabel, Manfred Boehm
  • Patent number: 6894154
    Abstract: Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: May 17, 2005
    Assignee: Regents of the University of Michigan
    Inventors: Gary J. Nabel, Elizabeth G. Nabel, Manfred Boehm
  • Patent number: 6790478
    Abstract: In a ceramic hybrid substrate and a method for treating the surface of a ceramic hybrid substrate having ceramic surface areas and metallic surface areas, the ceramic surface areas are esterified.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: September 14, 2004
    Assignee: Robert Bosch GmbH
    Inventors: Walter Roethlingshoefer, Manfred Boehm
  • Patent number: 6770473
    Abstract: Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: August 3, 2004
    Assignee: The Regents of the University of Michigan
    Inventors: Gary J. Nabel, Elizabeth G. Nabel, Manfred Boehm
  • Publication number: 20040146982
    Abstract: Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.
    Type: Application
    Filed: March 11, 2004
    Publication date: July 29, 2004
    Applicant: The Regents of the University of Michigan
    Inventors: Gary J. Nabel, Elizabeth G. Nabel, Manfred Boehm
  • Patent number: 6246664
    Abstract: Digital signals are commonly transmitted using the single-carrier method or the multicarrier method, for example. Both methods use one carrier frequency per transmission channel or subchannel of predetermined bandwidth. According to the invention, at least two carrier frequencies (f1, f2, f3) are used to increase the transmission capacity of a channel. The distance between two carrier frequencies is less than the absolute value of a carrier frequency (f1, f2, f3) by a factor of, e.g., 500. The beat frequency resulting from the combination (ADD) of several carrier frequencies (f1, f2, f3) in a channel is negligible, particularly if the transmitted carrier frequencies (f1, f2, f3) are in phase at the start of oscillations. By the combination (ADD) of several carrier frequencies (f1, f2, f3), equal resulting carrier frequencies can be obtained for different bit streams (DATA1, DATA2, DATA3).
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: June 12, 2001
    Assignee: Alcatel
    Inventor: Manfred Böhm
  • Patent number: 5073748
    Abstract: A numerically-controlled driving system has a rate-of-change limiter that is applicable to positioning- and continuous-path-control systems as used in robots, machine tools, elevators, etc. When control signals are input, sudden variations in acceleration or velocity are damped, because the discrete control values calculated by a numerical control system are filtered by a pulse filter in accordance with the principle of discrete convolution.
    Type: Grant
    Filed: September 27, 1990
    Date of Patent: December 17, 1991
    Assignee: Siemens Aktiengesellschaft
    Inventor: Manfred Boehm
  • Patent number: 5070287
    Abstract: A numerical positioning control system renders possible clocked-synchronous acceleration, and deceleration operations for motorized driving systems (A). A specified target point (PO), which for example can be the end point of a path section, can be reached with a predetermined final velocity (V.sub.END) exactly at a calibration time (T) of the numerical control. At least two acceleration values (a.sub.1,a) are defined for the acceleration, and braking operation, whereby the time which is required for the entire acceleration operation is exactly an integral multiple of the calibration time (T) of the numerical control. To avoid sudden changes in acceleration, a rate-of-change limiter is implemented according to the principle of discrete convolution.
    Type: Grant
    Filed: September 27, 1990
    Date of Patent: December 3, 1991
    Assignee: Siemens Aktiengesellschaft
    Inventor: Manfred Boehm