Patents by Inventor Manfred Biebl

Manfred Biebl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130087065
    Abstract: A vehicle safety system includes a module including an airbag and an inflator. The inflator includes a housing (12) in which a combustion chamber (16) containing a pyrotechnic propellant is arranged in which hot gas is generated and which housing includes at least one escape orifice (22) toward the environment of the inflator (10), as well as a coolant reservoir (24) arranged in the housing (12) in which coolant is accommodated prior to activation of the inflator (10) and which has at least one coolant outlet orifice (28?). The coolant outlet orifice (28) is arranged in direct vicinity of the outlet orifice (22). Upon activation of the inflator (10) coolant flows out of the inflator into the protection system and wets an adjacent wall (32) of the protection system against which also the hot gas is flowing.
    Type: Application
    Filed: September 14, 2012
    Publication date: April 11, 2013
    Inventors: Manfred Biebl, Michael Gabler, Achim Hofmann, Dieter Leier, Ning Wei
  • Patent number: 8329393
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: December 11, 2012
    Assignee: Hyglos Invest GmbH
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Grallert
  • Publication number: 20120164126
    Abstract: The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.
    Type: Application
    Filed: October 19, 2011
    Publication date: June 28, 2012
    Applicant: HYGLOS INVEST GMBH
    Inventors: Michael Forchheim, Holger Grallert, Anja Philipp, Manfred Biebl
  • Publication number: 20120122124
    Abstract: The present invention relates to bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysaccharides. The invention further relates to nucleic acid molecules comprising a sequence encoding the proteins according to the present invention. In addition, the present invention relates to a method for generating bacteriophage adhesion proteins according to the present invention. The invention further relates to the use of said proteins and methods of detection, purification and enrichment of bacteria.
    Type: Application
    Filed: July 3, 2009
    Publication date: May 17, 2012
    Inventors: Manfred Biebl, Renate Grassl, Monika Walter, Stefan Miller
  • Publication number: 20110306068
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Application
    Filed: July 12, 2011
    Publication date: December 15, 2011
    Applicant: HYGLOS INVEST GMBH
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Grallert
  • Patent number: 8058225
    Abstract: The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.
    Type: Grant
    Filed: August 19, 2008
    Date of Patent: November 15, 2011
    Assignee: Hyglos Invest GmbH
    Inventors: Michael Forchheim, Holger Grallert, Anja Philipp, Manfred Biebl
  • Patent number: 8003313
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: August 23, 2011
    Assignee: Hyglos Invest GmbH
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Grallert
  • Publication number: 20090202512
    Abstract: The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.
    Type: Application
    Filed: August 19, 2008
    Publication date: August 13, 2009
    Inventors: MICHAEL FORCHHEIM, Holger Grallert, Anja Philipp, Manfred Biebl
  • Publication number: 20090017445
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Application
    Filed: January 23, 2006
    Publication date: January 15, 2009
    Applicant: PROFOS AG
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Graller