Patents by Inventor Manfred Birchler

Manfred Birchler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
    Patent number: 8097254
    Abstract: The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabelled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. an appropriately chosen photosensitizer or radionuclide), and their use for the selective light-mediated occlusion of new blood vessels.
    Type: Grant
    Filed: April 12, 2004
    Date of Patent: January 17, 2012
    Assignee: Eidgenossische Technische Hochschule Zurich
    Inventors: Dario Neri, Lorenzo Tarli, Francesca Viti, Manfred Birchler
  • Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
    Publication number: 20070189963
    Abstract: The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis Furthermore, it relates to the use of radiolabeled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. a judiciously chosen photosensitizer), and their use for the selective light-mediated occlusion of new blood vessels.
    Type: Application
    Filed: December 13, 2006
    Publication date: August 16, 2007
    Inventors: Dario Neri, Lorenzo Tarli, Francesca Viti, Manfred Birchler
  • Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
    Publication number: 20060133994
    Abstract: The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabelled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. an appropriately chosen photosensitizer or radionuclide), and their use for the selective light-mediated occlusion of new blood vessels.
    Type: Application
    Filed: April 12, 2004
    Publication date: June 22, 2006
    Inventors: Dario Neri, Lorenzo Tarli, Francesca Viti, Manfred Birchler
  • Specific binding molecules for scintigraphy
    Publication number: 20030176663
    Abstract: The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabeled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising comprising said antibody.
    Type: Application
    Filed: December 18, 2002
    Publication date: September 18, 2003
    Applicant: Eidgenossische Technische Hochscule
    Inventors: Dario Neri, Lorenzo Tarli, Francesca Viti, Manfred Birchler
  • SPECIFIC BINDING MOLECULES FOR SCINTIGRAPHY, CONJUGATES CONTAINING THEM AND THERAPEUTIC METHOD FOR TREATMENT OF ANGIOGENESIS
    Publication number: 20030045681
    Abstract: The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabeled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. a judiciously chosen photosensitizer), and their use for the selective light-mediated occlusion of new blood vessels.
    Type: Application
    Filed: April 28, 1999
    Publication date: March 6, 2003
    Applicant: ANTHONY J. ZELANO
    Inventors: DARIO NERI, LORENZO TARLI, FRANCESCA VITI, MANFRED BIRCHLER