Abstract: The invention relates to flavor-masked pharmaceutical compositions for oral administration, their preparation and their use as medicaments.The new pharmaceutical preparations according to the invention make it possible to administer pharmaceutical active substances having very unpleasant organoleptic properties such as, for example, very bad taste, even in liquid form.

Abstract: A process for the continuous fluidized bed agglomeration of a solid in powder form, wherein the powder, a granulating liquid and propelling air are fed through a three-substance nozzle into the center of a fluidized bed to form a three-phase mixture in the center of the fluidized bed.

Abstract: The invention relates to flavour-masked pharmaceutical compositions for oral administration, their preparation and their use as medicaments.The new pharmaceutical preparations according to the invention make it possible to administer pharmaceutical active substances having very unpleasant organoleptic properties such as, for example, very bad taste, even in liquid form.

Abstract: Process for the continuous fluidized bed agglomeration wherein the granulating liquid together with propellant air is supplied centrally through a three-phase nozzle on the distributor of the fluidized bed, and at the same time, the solid in powder form is fed into the fluidized bed through the annular space or the three-phase nozzle with the air of a current of propellant air, supplied separately and concentrically.

Abstract: Controlled release medicament pellets comprisinga) a core which contains as active ingredient a compound of the formula ##STR1## or a compound from the group of 3-(4-fluorophenylsulphonamido)-1,2,3,4-tetrahydro-9-carbazole propanoic acid or 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3 (2H)-one 1,1-dioxide monohydrochloride, an intensive disintegrating agent, a wetting agent and a binder,b) a double layer which controls release comprising(b1) an acrylic-based outer undigestible water-permeable lacquer layer, and(b2) an inner jacket layer comprising a hydrophobic additive and hydroxypropylcellulose of type M or H.

Abstract: The invention relates to a process for the preparation of fine-particled, stable, pharmaceutical or cosmetic dispersions consisting of an aqueous phase and an organic phase which is insoluble or not completely soluble in water (oily phase), in which a pre-emulsion is first prepared from the two phases by known emulsifying methods and is then further processed to the end product. The invention furthermore relates to apparatus for carrying out the process.

Abstract: The invention relates to a process for the preparation of fine-particled, stable, pharmaceutical or cosmetic dispersions consisting of an aqueous phase and an organic phase which is insoluble or not completely soluble in water (oily phase) in which a pre-emulsion is prepared from the two phases by known emulsifying methods and in then pumped through a jet disperser, the temperature, the proportion of the aqueous and organic phases, and the pressure at the jet disperser being adjusted so that phase inversion of the emulsion is effected in the jet disperser at the same time as homogenization and fine dispersion, and in the course of which all the pressure energy is consumed in the dispersing zone and the dispersion leaves as a non-directional stream.

Abstract: A solid medicament preparation having long-lasting action containing a sparingly soluble dihydropyridine active compound of the Formula (I) ##STR1## the preparation having a core-coating construction, the core containing at least one of the above mentioned dihydropyridines in slow-release form, the inner-most coating situated around the core contains no active compound and only dissolves slowly and adjacent to the inner-most coating a rapid release initial dose of the active compound mixed with a polymer.

Abstract: A pharmaceutical formulation tablet with a long-lasting action for 1 to 2 daily doses having a diameter between about 0.5 and 15 mm and comprising(a) a rapid-release core of a dihydropyridine,(b) a coat containing no active compound and formed of a free-flowing powder mixture or of granules, and(c) optionally, a further coating of a rapid-release dihydropyridine formulation.

Abstract: A laser welding process includes the steps of deflecting, with an oscillating frequency of at least 100 Hz, a collimated and focused laser measuring beam, intensity-modulated with a frequency of at least 200 kHz, across the path of the weld groove during co-travel with the laser welding beam along the weld groove; directing the laser measuring beam to the workpieces; causing the laser measuring beam to impinge on the workpieces at a distance of maximum 10 mm from the central longitudinal axis of the laser welding beam; sensing, by an electro-optical sensor having a single light-sensitive element, rays of the laser measuring beam reflected by the workpieces; generating, by the sensor, measuring signals in response to the sensed reflected rays; applying follow-up signals in response to the measuring signals, and correcting the position of the laser welding beam by the follow-up device in response to the follow-up signals applied thereto.

Abstract: The invention relates to antimycotic compositions comprising (1) an antimycotic effective amount of an azole derivative having antimycotic activity, said azole derivative being in the form of particles less than 4.mu. in size, (2) an acid and/or a buffer system consisting of an organic acid and a salt thereof to provide a pH of 3 to 4 or less in aqueous solution and (3) an inert pharmaceutical carrier. Also included in the invention are methods for the short term treatment of vaginal infections utilizing the compositions of the invention.

Abstract: The invention relates to a process for preparing fine-particled, stable, pharmaceutical or cosmetic dispersions which comprises dispersing the entire inner phase in 5-40% by volume of outer phase, then adding the remainder of the outer phase, all under predetermined conditions.