Abstract: Novel cyclic polyamine compounds of the form where A1, each A2 (if present), and A3 are independently selected from C1-C8 alkyl, where each Y is independently selected from H or C1-C4 alkyl, where M is selected from C1-C4 alkyl, where k is 0, 2, or 3, and where R is selected from C1-C32 alkyl, as well as all stereoisomers and salts thereof, are disclosed. Additional compounds where k is 1 and A2 is independently selected from C1-C3 alkyl or C5-C8 alkyl are also disclosed. Cyclic polyamines, where the amide group is reduced to a secondary amino group, and various derivatives of these compounds, are also described. Synthetic methods for the compounds are described. The compounds are useful for treating diseases caused by uncontrolled proliferation of cells, such as cancer, especially prostate cancer, and for inducing intracellular ATP hydrolysis for treatment of other disorders.

Abstract: A fuel pump for use in a fuel injection system includes a housing at least one piston defining a work chamber and drive means which put the piston into a reciprocating motion in the chamber. An inlet conduit and an outlet conduit can be made to communicate with the work chamber. A first valve device is provided between the inlet conduit and the work chamber, and a second valve device is provided between the work chamber and the outlet conduit. The valve element of one valve device has a guide portion, which is received in a guide opening embodied in the valve element of the other valve device, and the circumferential face of the guide portion and/or of the guide opening has at least one recess, by which the contact area between the guide portion and the guide opening is reduced.

Abstract: A fuel pump for use in a fuel injection system includes a housing at least one piston defining a work chamber and drive means which put the piston into a reciprocating motion in the chamber. An inlet conduit and an outlet conduit can be made to communicate with the work chamber. A first valve device is provided between the inlet conduit and the work chamber, and a second valve device is provided between the work chamber and the outlet conduit. The valve element of one valve device has a guide portion, which is received in a guide opening embodied in the valve element of the other valve device, and the circumferential face of the guide portion and/or of the guide opening has at least one recess, by which the contact area between the guide portion and the guide opening is reduced.

Abstract: Novel cyclic polyamine compounds of the form 1