Abstract: The present disclosure relates to the treatment of cancer and/or cancer-associated disease. Certain aspects relate to the treatment of an individual having cancer or cancer-associated disease by administering to the individual a combination therapy of a first therapeutic agent that is an EZH2 inhibitor, a second therapeutic agent that is a CDK inhibitor, and a third therapeutic agent that is a selective estrogen receptor degrader.

Abstract: The present disclosure provides technologies for achieving treatment of cancer. The present disclosure provides methods and compositions for the treatment of cancer using oncoselective construct designs that can be used to encode payloads of high therapeutic interest. The present disclosure recognizes that treatment of individuals suffering from cancer with engineered nucleic acids of the disclosure in combination with immune checkpoint therapy provides unique advantages.

Abstract: A battery housing for an electrical device, such as a portable telephone, has a locking mechanism that locks the battery housing in place onto the housing of the portable device. The locking mechanism has a locking finger that is inserted into an opening in the device housing. The locking finger is spring mounted on the housing bottom of the battery housing and collaborates with at least one sliding surface which preferably has the shape of an inclined plane over which the locking finger can be forced out of the locked position by means of a movable key.

Abstract: The invention concerns the use of test strips with a flat, preferably oblong foil which carries a matrix containing a photoactive chromogenic substance to pre-determine the duration of stay in the sun that is possible without sunburn, a test system for this determination containing test strips and a test strip pack, a test strip pack and a method for the pre-determination of the maximum possible duration of stay in the sun without sunburn using the test system.

Abstract: A test carrier for the analysis of fluids has a test field which is held in a frame and a test application surface for the application of a sample fluid. Sometimes called an "analysis chip", such devices are suitable for accommodating a test layer pack which has a plurality of layers lying loosely on one another. These devices are thin and allow for low cost manufacturing and simple and efficient handling, and has a base body of a plastic material, with a trough-shaped depression for accommodating the test field therein. A retaining net of a plastic material spans above the depression and the test field.

Abstract: Test carrier for the analysis of fluids with a frame (2) consisting of at least two parts surrounding a test field opening (6) and with a test field disposed in the test field opening (6). In order to provide such a test carrier with frame with which it is possible to assemble the test field out of several test layers manufactured separately from one another, it is proposed that the test field be designed as a test layer package (7) with test layers (10, 11, 12) resting loosely on one another, the frame (2) comprise two shaped pieces of plastics material, one of which serves as base part (4) and comprises a seat (16) for accommodating the test layers (10, 11, 12), while the other serves as lid part (3) and comprises a bearing surface (17) resting on the topmost layer (10) of the test layer package (7).

Abstract: Test carrier for the analysis of fluids with a test field (7) held in a frame (2), in which the frame (2) comprises a top part (3) and a base part (4) and at least the top part (3) comprises a test field opening (6) through which a sample fluid can be applied to the surface (7a) of the test field. Simplified handling and improved analytical reliability are achieved by the fact that the base part (4) comprises a seat (16) for the test field (7) which is surrounded by positioning elements (15) which are higher than the test field (7). The test field opening (6) is greater than the test field (7), so that the rim (18) of the test field is visible. The top part (3) comprises pressure tongues resting on the surface (7a) of the test field (7) and projecting into the test field opening (7).

Abstract: A process for producing vodka by distilling one aqueous solution of alcohol having a relatively low alcohol content from a potstill. The volume of the solution in the still is maintained by a flow of another aqueous solution of alcohol of relatively high alcohol content. The vapor is condensed to produce Vodka. In the process the one solution has an alcohol content of about 4.5% by volume and a mineral content. The other solution has an alcohol content of about 41% by volume. The distillate is condensed and admixed with undistilled solution from the still to provide a vodka with an alcohol content of about 40% and the minerals content from the first solution. An apparatus able to carry out the process is described.

Abstract: The invention relates to a readjustment device on coking oven batteries with linkages, disposed in a master gallery so as to be movable in the longitudinal direction of the battery, for the actuation of shutoff members on the individual ovens of the coking oven battery. The linkages, to be moved simultaneously and oppositely in the master gallery, are joined to each other at one end of the coking oven battery through a guide pulley and this guide pulley is provided with pulley segments having different radii to obtain different strokes at the linkages.

Abstract: A switching lever mechanism for operating a switching lever between two end positions comprising first and second laterally spaced apart cams, a follower lever physically mounted between its ends and including one end with a roller follower disposed between the cams. An opposite end of the follower lever is connectible to a member for shifting the member. A socket is formed on the follower lever between the roller follower and the pivotal mounting thereof and a bolt having a spherical head is pivotally mounted on the socket. A bracket mounted in a stationary position alongside the follower lever is provided with a set screw having a head portion. A sleeve is pivotally mounted on the head portion and carries the bolt. A spring biases the sleeve and bolt outwardly to hold the follower lever in either of its two end positions.

Abstract: A combined control device for the operation of coke oven batteries which includes both a part for converting from heating with a strong gas to a lean gas, and vice versa, and a part for switching the regenerative heating system from one group of heating flues to another, comprises a support frame on which is mounted a rotary switching control cylinder and a rotary conversion control cylinder in end-to-end relationship and for rotation around the same axis. The rotary conversion control cylinder is displaceable in respect to the rotary switching control cylinder, and the two cylinders may be coupled together for rotation together or the conversion cylinder may be shifted axially so that it will not rotate with the switching control cylinder. The switching control cylinder is driven at one side from a motor driven transmission which also permits the manual operation of the cylinders.