Abstract: An orthopedic pin is for optically analyzing a bone region. An optical fiber arrangement extends within an elongate shaft from a distal end to a proximal end. There is a coupling at an intermediate position along the shaft, and the optical fiber arrangement comprises a first portion on one side of the coupling and a second portion on the other side of the coupling. The coupling allows relative rotation between portions of the shaft at opposite sides of the coupling, while maintaining optical coupling between the first and second portions of the optical fiber.

Abstract: A monitoring system includes an implantable intra-vascular support device for positioning against a vessel wall and an implantable sensor-actuator mounted to the support device. The sensor-actuator is drivable between a non-deployed position in which it is against the support device and a deployed position in which it is displaced away from the support device. Sensor signals are generated when in the deployed position. This system is able to monitor flow away from the edge of a vessel by deploying the sensor-actuator towards the center of the vessel. When flow monitoring does not need to take place, it can be non-deployed so that it does not present an occlusion to the flow.

Abstract: The present disclosure relates to an inhaler adapted to supply a formulation comprised in a container to a user, the inhaler being adapted to read information stored in data storage means of the container. The present disclosure also relates to a system comprising such an inhaler and the container comprising the formulation, the container further comprising the data storage means storing the information. The present disclosure also relates to a container comprising a formulation, the container further comprising data storage means storing information, the container being adapted for supplying the formulation to a user, wherein the container is adapted for usage in an inhaler of any of the preceding claims. The disclosure also relates to set comprising the inhaler and a computing device external of the inhaler, wherein the inhaler and the computing device are adapted to communicate with each other. The disclosure also relates to the use of the inhaler, container, set and/or system for inhalation therapy.

Abstract: Method and related system for marker-based navigation. A first image is capturing (S530) with a medical imaging apparatus (ENDO), whilst a light source (LS1) of an implanted marker device (MD) is in a low intensity state and a second light source (LS2) of the medical imaging apparatus (IA) is in a high intensity state, higher than the low intensity state of the marker. A second image is captured (S560) with the medical imaging apparatus (ENDO), whilst the light source (LS1) of the implanted marker device is in a high intensity state and the second light source (LS2) of the medical imaging apparatus (IA) is in a low intensity state, lower than the high intensity state of the marker. The two images may then be combined to obtain a combined image that represents the location of the marker at high signal-to-noise-ratio.

Abstract: The invention relates to an apparatus for determining a property of a tissue, particularly cancer of cervical tissue. A light providing unit (7, 8, 9) provides light for illuminating the tissue (6) and a light detection unit (10) detects light from the tissue, wherein a first signal being indicative of light (11) having been influenced by an epithelium region (R1), a second signal being indicative of light (12) having been influenced by a boundary region (R2) and a third signal being indicative of light (13) having been influenced by a stroma region (R3) are generated, and wherein a tissue property is determined based on the first, second and third signals. This allows for an determination of a tissue property, which is based on a combination of optical properties measured in the three different regions, resulting in an improved determination of the tissue property, in particular in improved cancer detection.

Abstract: The invention is directed to systems and methods for determining a fundamental pulse wave velocity value for a vessel with minimized effect of reflections originating from the vessel network connected distal to the respective vessel.

Abstract: The present invention relates to the context of renal denervation. In order to provide further improvement in relation to the outcome of renal denervation, an apparatus (10) for renal denervation preparation is provided that comprises an input unit (12), ha processing unit (14) and an output unit (16). The input unit is configured to receive first artery parameter data and second artery Ge parameter data. The first artery parameter data relates to artery stiffness of a renal artery part of a subject, and the second artery parameter In data relates to artery stiffness of a non-renal artery part of the subject.

Abstract: A monitoring system includes an implantable intra-vascular support device for positioning against a vessel wall and an implantable sensor-actuator mounted to the support device. The sensor-actuator is drivable between a non-deployed position in which it is against the support device and a deployed position in which it is displaced away from the support device. Sensor signals are generated when in the deployed position. This system is able to monitor flow away from the edge of a vessel by deploying the sensor-actuator towards the center of the vessel. When flow monitoring does not need to take place, it can be non-deployed so that it does not present an occlusion to the flow.

Abstract: A device for the variable fixing of a headrest to a vehicle seat, having a receptacle (1) forming a receiving space (5) a headrest support, and having a locking element (7) which, by a disengagement movement of a disengagement element (10), is movable from a locking position, in which a locking section (18) of the locking element (7) projects into the receiving space, into a release position, in which the locking section does not project into the receiving space or projects into the receiving space to a lesser extent than in the locking position and movement of the disengagement element leads along the longitudinal axis (9) of the receiving space (5). The movement of the disengagement element (10) can be effected by an actuation movement (12) of an actuation element (11), wherein the direction of the actuation movement (12) is oriented perpendicular to the longitudinal axis.

Abstract: The rod coupler according to the present invention comprises two clamping jaws and locking means for locking said clamping jaws against one another. Each clamping jaw comprises an outside surface and a clamping surface, the latter providing at least a first and a second groove. Each groove runs laterally from a different part of the outside surface extending into the rod coupler, wherein longitudinal axis of the first groove and the second groove include an angle that is equal to or less than 160 degrees. Opposing grooves form an aperture. The apertures are adapted for receiving a rod if the locking means is released. Clamping jaws that are locked by the locking means clamp the rods received in said apertures.

Abstract: A device for the variable fixing of a headrest to a vehicle seat, having a receptacle (1), which forms a receiving space (5) for receiving a headrest support (6), and having a locking rocker (7) which, by means of an actuation movement of an actuation element (11), can be rotated from a locking position, in which a locking section (18) of the locking rocker (7) projects into the receiving space, into a release position, in which the locking section (18) does not project into the receiving space or projects into the receiving space (5) to a lesser extent than in the locking position, is characterized in that the direction of the actuation movement is not oriented perpendicular to the axis of rotation (25) about which the locking rocker (7) is rotatable.

Abstract: Laser siping forms sipes in an article. The laser operates in a scan laser configuration for some sipe patterns and the laser operates in a fixed laser concept for other siping patterns. The article on which the sipes are formed is secured by a part holder. Movement of the part holder may be computer controlled. Movement of the laser may also be computer controlled. A movement of a reflective surface of the laser may be computer controlled. Together, the movement of the part holder, the laser, and the reflective surface is coordinated to achieve the scan laser configuration and the fixed laser configuration when forming sipes.

Abstract: A device for the variable fixing of a headrest to a vehicle seat, having a receptacle (1) forming a receiving space (5) a headrest support, and having a locking element (7) which, by a disengagement movement of a disengagement element (10), is movable from a locking position, in which a locking section (18) of the locking element (7) projects into the receiving space, into a release position, in which the locking section does not project into the receiving space or projects into the receiving space to a lesser extent than in the locking position and movement of the disengagement element leads along the longitudinal axis (9) of the receiving space (5). The movement of the disengagement element (10) can be effected by an actuation movement (12) of an actuation element (11), wherein the direction of the actuation movement (12) is oriented perpendicular to the longitudinal axis.

Abstract: A device for the variable fixing of a headrest to a vehicle seat, having a receptacle (1), which forms a receiving space (5) for receiving a headrest support (6), and having a locking rocker (7) which, by means of an actuation movement of an actuation element (11), can be rotated from a locking position, in which a locking section (18) of the locking rocker (7) projects into the receiving space, into a release position, in which the locking section (18) does not project into the receiving space or projects into the receiving space (5) to a lesser extent than in the locking position, is characterized in that the direction of the actuation movement is not oriented perpendicular to the axis of rotation (25) about which the locking rocker (7) is rotatable.

Abstract: The present invention relates to a system (10) for navigating and positioning an instrument (12, 40, 112) in a body (14). The instrument (12, 40, 112) is detectable by the system (10) and the system (10) displays a view to an operator. The instrument (12, 40, 112) is adapted to identify tissue parameters. The system (10) is adapted to display an image being a combined image of the interior of a body (14) and an indication of the tissue parameter at the appropriate earlier locations. The present invention further relates to a method (44) including determining tissue parameters and displaying the parameters in an image of a body (14). The present invention further relates to a software implemented method (44) for being executed on a digital processor. The present invention further relates to an instrument (12, 40, 112).

Abstract: The invention relates to a dispensing module (1) for an applicator head for dispensing a fluid, in particular hot-melt adhesive, comprising a module housing (5), a valve body accommodated in the module housing (5), an adapter (7) through which the valve body extends, comprising a proximal end (49) and a distal end (41), the distal end (41) being connected by means of a screw connection (51) to the module housing (5), a nozzle holder (9) which is adapted to be inserted into a matching recess in a base member of the applicator head, and one or a plurality of sealing elements (57, 59, 61) for sealing the nozzle holder (9) and the base member against each other in a fluid-tight manner.

Abstract: The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps: (a) provision of a support having a surface area which contains a plurality of individual reaction areas, (b) location-resolved synthesis of nucleic acid fragments having in each case different base sequences in several of the individual reaction areas, and (c) detachment of the nucleic acid fragments from individual reaction areas.

Abstract: The invention relates to an apparatus for determining a property of a tissue, particularly cancer of cervical tissue. A light providing unit (7, 8, 9) provides light for illuminating the tissue (6) and a light detection unit (10) detects light from the tissue, wherein a first signal being indicative of light (11) having been influenced by an epithelium region (R1), a second signal being indicative of light (12) having been influenced by a boundary region (R2) and a third signal being indicative of light (13) having been influenced by a stroma region (R3) are generated, and wherein a tissue property is determined based on the first, second and third signals. This allows for an determination of a tissue property, which is based on a combination of optical properties measured in the three different regions, resulting in an improved determination of the tissue property, in particular in improved cancer detection.

Abstract: A multi-part piston ring, containing an at least single-part spring support which is provided with a piston ring joint region and an at least single-part spring element, which is positioned in a groove provided in the region of the inner circumferential face of the spring support, wherein the wall thickness of the spring support is essentially equal in the region of the ends of the spring support facing the piston ring joint and in the rear region of the spring support, and a pocket which extends over a circumferential range of at least 60° and is created by local reduction of the wall thickness of the spring support is provided in each case between the rear region and the piston ring joint ends.

Abstract: The rod coupler according to the present invention comprises two clamping jaws and locking means for locking said clamping jaws against one another. Each clamping jaw comprises an outside surface and a clamping surface, the latter providing at least a first and a second groove. Each groove runs laterally from a different part of the outside surface extending into the rod coupler, wherein longitudinal axis of the first groove and the second groove include an angle that is equal to or less than 160 degrees. Opposing grooves form an aperture. The apertures are adapted for receiving a rod if the locking means is released. Clamping jaws that are locked by the locking means clamp the rods received in said apertures.