Patents by Inventor Manfred Mutter

Manfred Mutter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8501683
    Abstract: At least one embodiment of the present invention relates to new cycloundecadepsipeptide compounds and to the use of said compounds as a medicament, in particular as antiviral agents, more particularly for preventing or treating Hepatitis C infections or HCV induced disorders.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: August 6, 2013
    Assignee: Debio Recherche Pharmaceutique S.A.
    Inventors: Roland Wenger, Manfred Mutter, Patrick Garrouste, Robert Lysek, Olivier Turpin, Grégoire Vuagniaux, Valérie Nicolas, Laura Novaroli Zanolari, Rafael Crabbé
  • Publication number: 20110212057
    Abstract: At least one embodiment of the present invention relates to new cycloundecadepsipeptide compounds and to the use of said compounds as a medicament, in particular as antiviral agents, more particularly for preventing or treating Hepatitis C infections or HCV induced disorders.
    Type: Application
    Filed: November 6, 2009
    Publication date: September 1, 2011
    Applicant: Debio Recherche Pharmaceutique S.A.
    Inventors: Roland Wenger, Manfred Mutter, Patrick Garrouste, Robert Lysex, Olivier Turpin, Grégoire Vuagniaux, Valérie Nicolas, Laura Novaroli Zanolari, Rafael Crabbé
  • Publication number: 20100152418
    Abstract: The present invention relates to a method for the manufacture of a peptidic folding precursor (Switch-Peptide) stable and soluble at physiological conditions, derived from a peptide having a potential for self-assembling and fibrillogenesis. Another object of the invention is to provide a tool for the quantitative, controlled in vitro study of fibrillogenesis and its inhibition of peptides involved in degenerative diseases.
    Type: Application
    Filed: June 16, 2006
    Publication date: June 17, 2010
    Applicant: EPFL ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
    Inventors: Manfred Mutter, Gabriele Tuchscherer
  • Patent number: 6995139
    Abstract: A pro-drug comprising a cyclic undecapeptide wherein the peptide chain thereof comprises at least one amino acid residue, useful as a medicinal product, including use for treatment of pathological conditions of the eye.
    Type: Grant
    Filed: April 22, 2002
    Date of Patent: February 7, 2006
    Assignee: Debiopharm S.A.
    Inventors: Roland Wenger, Manfred Mutter, Amaud Hamel, Francis Hubler
  • Patent number: 6927208
    Abstract: The invention relates to a novel cyclosporin, the pharmaceutical use thereof and a pharmaceutical composition containing it.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: August 9, 2005
    Assignee: Debiopharm S.A.
    Inventors: Roland M. Wenger, Manfred Mutter, Thomas Ruckle
  • Patent number: 6790935
    Abstract: The invention relates to cyclosporin derivatives, whereby the peptide chain thereof comprises at least one pseudo-proline type non-natural amino acid radical. The invention also relates to a method for the production of said derivatives.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: September 14, 2004
    Assignee: Debiopharm S.A.
    Inventors: Manfred Mutter, Roland Wenger, Jean-François Guichou, Michael Keller, Thomas Ruckle, Torsten Woehr
  • Publication number: 20040138108
    Abstract: The invention relates to a pro-drug comprising a cyclic undecapeptide wherein the peptide chain thereof comprises at least one amino acid residue of general formula (1) wherein the carbon atom Ca is one of the links in said undecapeptide cycle; —substituents Y individually represent a hydrogen atom or form a bond together; —substitutents R1 and R3 independently represent a hydrogen atom, an aralkyl group, an alkaryl group, a heteroalkyl group, a heterocyclic group, a heterocyclic alkyl group, an alkyl heterocyclic group or an alkyl group having 1-6 carbon atoms which is linear or branched, and which is optionally substituted by at least one of the groups chosen from among —COOH, —CONHR8, —NHCO═NH(NH2), —NHC═NR8(NH2), —NH2, —NHR8, —NR82, —N+R83, —OH, —OPO(OR8)2, —OPO(OH)(OR8), —OPO(OH)2, —OSO(OR8)2, —OSO(OH)(OR8), —OSO(OH)2, and the different salts produced therefrom, each of the substituents R8
    Type: Application
    Filed: October 9, 2003
    Publication date: July 15, 2004
    Inventors: Roland Wenger, Manfred Mutter, Arnaud Hamel, Francis Hubler
  • Publication number: 20040009905
    Abstract: The present invention is directed to agonists of neuropeptide Y (NPY) or PYY that are formed by combining these peptides or a portion of these peptides with a template that promotes biologically active folds. Typically, templates consist of cyclized peptides containing one or more naphthyl ring structures. The agonists may be used in the treatment of diseases and conditions known to be responsive to NPY or PYY and, particularly in the treatment of asthma, rhinitis, and bronchitis.
    Type: Application
    Filed: June 18, 2003
    Publication date: January 15, 2004
    Applicant: B.M.R.A. Corporation B.V.
    Inventors: Manfred Mutter, Jean-Silvain Lacroix, Eric Grouzmann
  • Patent number: 6288029
    Abstract: The present invention is directed to agonists of neuropeptide Y (NPY) or PYY that are formed by combining these peptides or a portion of these peptides with a template that promotes biologically active folds. Typically, templates consist of cyclized peptides containing one or more naphthyl ring structures. The agonists may be used in the treatment of diseases and conditions known to be responsive to NPY or PYY and, particularly in the treatment of asthma, rhinitis, and bronchitis.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: September 11, 2001
    Inventors: Manfred Mutter, Jean-Silvain Lacroix, Eric Grouzmann
  • Patent number: 6017879
    Abstract: The present invention is directed to agonists of neuropeptide Y (NPY) or PYY that are formed by combining these peptides or a portion of these peptides with a template that promotes biologically active folds. Typically, templates consist of cyclized peptides containing one or more naphthyl ring structures. The agonists may be used in the treatment of diseases and conditions known to be responsive to NPY or PYY and, particularly in the treatment of asthma, rhinitis, and bronchitis.
    Type: Grant
    Filed: April 3, 1998
    Date of Patent: January 25, 2000
    Assignee: B.M.R.A. Corporation B.V.
    Inventors: Manfred Mutter, Jean-Silvain Lacroix, Eric Grouzmann
  • Patent number: 3960830
    Abstract: A process for the synthesis of peptides in a liquid phase wherein the peptide product, and intermediates in the peptide synthesis, are bound to a polyalkylene glycol polymer and wherein the polymer-bound peptide is separated from the liquid phase, e.g. for purposes of isolation or purification, by crystallizing the polymer-bound peptide.
    Type: Grant
    Filed: December 4, 1974
    Date of Patent: June 1, 1976
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ernst Bayer, Manfred Mutter
  • Patent number: RE40987
    Abstract: The invention relates to a novel cyclosporin, the pharmaceutical use thereof and a pharmaceutical composition containing it.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: November 17, 2009
    Assignee: Debiopharm S.A.
    Inventors: Roland M. Wenger, Manfred Mutter, Thomas Rückle