Abstract: The present invention relates to an anti-GDF15 antibody and to a dosage regimen for the treatment of cancer in a human patient using the anti-GDF15 antibody. The present inventors identified a mechanism by which GDF-15 blocks adhesion and transgression of predominantly T-lymphocytes into tissues. Hence, a novel treatment approach has been established by the present invention that facilitates effector T cell entry into tumor tissue upon blockage of GDF-15 using the antibody of the present invention thereby allowing the treatment of cancer in human patients.

Abstract: The invention relates to a method for determination of the muzzle velocity of a projectile (2) when it emerges from the firing barrel (1) of a shoulder-held weapon. In order not to weaken the firing barrel, it is proposed that a transmitter (3) for transmission of signals be arranged on the end face of the firing barrel (1) and that two sensors (9, 10), which are arranged at a distance d from one another, be arranged in or on the projectile (2) in order to detect the signals transmitted by the transmitter (3) and that these sensors (9, 10) detect a pulse on flying past the transmitter (3), and that the muzzle velocity for the projectile (2) be determined from the time difference between the pulses detected by the two sensors (9, 10).

Abstract: The invention relates to a method for determination of the muzzle velocity of a projectile (2) when it emerges from the firing barrel (1) of a shoulder-held weapon. In order not to weaken the firing barrel, it is proposed that a transmitter (3) for transmission of signals be arranged on the end face of the firing barrel (1) and that two sensors (9, 10), which are arranged at a distance d from one another, be arranged in or on the projectile (2) in order to detect the signals transmitted by the transmitter (3) and that these sensors (9, 10) detect a pulse on flying past the transmitter (3), and that the muzzle velocity for the projectile (2) be determined from the time difference between the pulses detected by the two sensors (9, 10).