Patents by Inventor Manfred R. Koller

Manfred R. Koller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and apparatus for selectively targeting specific cells within a mixed cell population
    Publication number: 20030180902
    Abstract: This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a mixed cell population, for the purpose of inducing a response in the targeted cells. Using the present invention, every detectable cell in a population can be identified and affected, without substantially affecting non-targeted cells within the mixture.
    Type: Application
    Filed: March 18, 2003
    Publication date: September 25, 2003
    Inventors: Bernhard O. Palsson, Manfred R. Koller, Timothy M. Eisfeld
  • Method and apparatus for selectively targeting specific cells within a mixed cell population
    Patent number: 6534308
    Abstract: This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a mixed cell population, for the purpose of inducing a response in the targeted cells. Using the present invention, every detectable cell in a population can be identified and affected, without substantially affecting non-targeted cells within the mixture.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: March 18, 2003
    Assignee: Oncosis, LLC
    Inventors: Bernhard O. Palsson, Manfred R. Koller, Timothy M. Eisfeld
  • Method and apparatus for selectively targeting specific cells within a cell population
    Patent number: 6514722
    Abstract: This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a cell population, for the purpose of inducing a response in the targeted cells. Using the present invention, every detectable cell in a population can be identified and affected, without substantially affecting non-targeted cells within the mixture.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: February 4, 2003
    Assignee: Oncosis
    Inventors: Bernhard O. Palsson, Manfred R. Koller, Timothy M. Eisfeld
  • Method and device for selectively targeting cells within a three-dimensional specimen
    Publication number: 20020177885
    Abstract: The invention provides an apparatus for electromagnetically affecting a particle of interest in a specimen. The apparatus includes (a) a stage capable of supporting the specimen; (b) a detector including at least one camera, wherein the detector is capable of resolving a particle of interest within the specimen; (c) a means for locating the particle of interest in three dimensions; (d) a means for focusing electromagnetic radiation to a focal volume within the specimen; and (e) a means for adjusting the relative positions of the stage and electromagnetic radiation focusing means, thereby positioning the particle of interest within the focal volume.
    Type: Application
    Filed: October 24, 2001
    Publication date: November 28, 2002
    Inventors: Timothy M. Eisfeld, Manfred R. Koller, Bernhard O. Palsson
  • Optoinjection methods
    Publication number: 20020076744
    Abstract: Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irradiating the target cell with a pulse of radiation.
    Type: Application
    Filed: September 21, 2001
    Publication date: June 20, 2002
    Inventors: Manfred R. Koller, Elie G. Hanania, Timothy M. Eisfeld, Bernhard O. Palsson
  • Method and apparatus for selectively targeting specific cells within a cell population
    Publication number: 20010005586
    Abstract: This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a cell population, for the purpose of inducing a response in the targeted cells. Using the present invention, every detectable cell in a population can be identified and affected, without substantially affecting nontargeted cells within the mixture.
    Type: Application
    Filed: November 30, 2000
    Publication date: June 28, 2001
    Inventors: Bernhard O. Palsson, Manfred R. Koller, Timothy M. Eisfeld