Patents by Inventor Manfred Rosner

Manfred Rosner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10421749
    Abstract: The present invention relates to compounds and compositions for use in methods of treating and/or preventing conditions, disorders or diseases that are mediated or caused by a virus.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: September 24, 2019
    Assignees: HELMHOLTZ ZENTRUM MÜNCHEN-DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH), LEIBNIZINSTITUT FÜR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E. V. -HANS-KNÖLL-INSTITUT
    Inventors: Ruth Brack-Werner, Markus Helfer, Manfred Rösner, Martha Schneider, Ulrike Protzer, Christian Hertweck, Martina Werneburg
  • Publication number: 20180118725
    Abstract: The present invention relates to compounds and compositions for use in methods of treating and/or preventing conditions, disorders or diseases that are mediated or caused by a virus.
    Type: Application
    Filed: April 7, 2016
    Publication date: May 3, 2018
    Inventors: Ruth BRACK-WERNER, Markus HELFER, Manfred RÖSNER, Martha SCHNEIDER, Ulrike PROTZER, Christian HERTWECK, Martina WERNEBURG
  • Patent number: 6369057
    Abstract: Compounds of the formula I or Ia in which n and the substituents R1, R5 and x have the meaning mentioned have an antiviral activity.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: April 9, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Uta-Maria Billhardt, Manfred Rösner, Günther Riess, Irvin Winkler, Rudolf Bender
  • Patent number: 6114349
    Abstract: Substituted quinoline derivatives, processes for their preparation, and their use.Compounds of the formula I ##STR1## and their tautomeric forms, of the formula Ia ##STR2## in which m, n and the substituents X and R.sup.1 to R.sup.5 have the meanings mentioned, have an action against viruses.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: September 5, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Reinhard Kirsch, Jorg-Peter Kleim, Gunther Riess, Bernd Rosenstock, Manfred Rosner, Irvin Winkler
  • Patent number: 5798365
    Abstract: Compounds of the formula I, ##STR1## and also their tautomeric forms of the formula Ia, ##STR2## in which the substituents R.sup.1 to R.sup.6 and X have said meanings, exhibit antiviral activity.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: August 25, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Reinhard Kirsch, Jorg-Peter Kleim, Gunther Riess, Manfred Rosner, Irvin Winkler
  • Patent number: 5723461
    Abstract: Disclosed are quinoxalinone compounds of the formula I or Ia ##STR1## and physiologically tolerated salts and prodrugs thereof, in which n=zero, one or two;R.sup.1 =fluorine, chlorine, hydroxyl or C.sub.1 -C.sub.3 -alkoxy; R.sup.2 =C.sub.1 -C.sub.4 -alkyl which is unsubstituted or is substituted by hydroxyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -alkylthio; R.sup.3 =C.sub.1 -C.sub.6 -alkyloxycarbonyl or C.sub.2 -C.sub.6 -alkenyloxycarbonyl, and X=oxygen, sulfur or selenium, a process for their preparation and pharmaceutical compositions containing the compounds.
    Type: Grant
    Filed: October 17, 1995
    Date of Patent: March 3, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Rosner, Uta-Maria Billhardt-Troughton, Reinhard Kirsch, Jorg-Peter Kleim, Christoph Meichsner, Gunther Riess, Irvin Winkler
  • Patent number: 5424311
    Abstract: Compounds of the formula I ##STR1## and their tautomeric form of the formula Ia ##STR2## in which the substituents R.sup.1 to R.sup.5 and V, W, Y and Z have the stated meanings, display an effect against viruses.
    Type: Grant
    Filed: September 23, 1993
    Date of Patent: June 13, 1995
    Assignee: Hoeschst Aktiengesellschaft
    Inventors: Uta-Maria Billhardt-Troughton, Manfred Rosner, Rudolf Bender, Christoph Meichsner
  • Patent number: 5188832
    Abstract: A method of using certain triazine-dione compounds for the control of endo- and ectoparasites of fish and/or insects. The compounds may be combined with aids to form an agent for controlling the endo- or ectoparasites.
    Type: Grant
    Filed: February 14, 1990
    Date of Patent: February 23, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinz Mehlhorn, Horst Taraschewski, Gunter Schmahl, Wolfgang Raether, Manfred Rosner
  • Patent number: 4871734
    Abstract: Thienoimidazole-toluidines of the formula I ##STR1## in which A represents ##STR2## T denotes --S--, --SO-- or --SO.sub.2 --, and R.sup.1 to R.sup.9 have the meanings stated in the description, and a process for their preparation, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion, are described.
    Type: Grant
    Filed: November 20, 1987
    Date of Patent: October 3, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Jochen Lang, Manfred Rosner, Weidmann, Klaus, Robert Rippel, Andreas W. Herling
  • Patent number: 4782056
    Abstract: Compounds of the formula I ##STR1## with n=1-3, R=H, Hal, CF.sub.3, alkyl, cycloalkyl, alkyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, benzylsulfinyl, benzylsulfonyl, nitro, cyano, amino, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidinyl, 4-methyl-1-piperazinyl, acylamino or substituted phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, benzoyl, benzoylamino or anilino, with R.sup.2 =H, alkyl, cycloalkyl, optionally substituted benzyl, alkanoyl or benzoyl and R.sup.3 =H, alkyl, cycloalkyl or optionally substituted benzyl, at least R.sup.2 or R.sup.3 not being H, are obtained by alkylation or acylation of a compound II ##STR2## in which R.sup.1 is as defined above, with compounds R.sup.3 X (X=leaving group) or R.sup.2 Y (Y=leaving group), R.sup.2 and R.sup.3 being defined as indicated.Compounds I are coccidiostatics.
    Type: Grant
    Filed: September 5, 1986
    Date of Patent: November 1, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Rosner, Wolfgang Raether
  • Patent number: 4640917
    Abstract: Substituted 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones of the formula ##STR1## in which n is one, two or three and the individual substituents R are independently of one another (a) hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl each having 1 to 6 carbon atoms in the alkyl moiety, nitro, cyano, amino, alkylamino or dialkylamino each having 1 to 12 carbon atoms in the alkyl moiety, piperidino, morpholino, thiomorpholino, 1-pyrrolidinyl, 4-methyl-1-piperazinyl or acylamino having 1 to 6 carbon atoms in the acyl moiety, or (b) a phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, benzoyl, benzoylamino or aniline radical which is in each case R.sub.(a) -substituted, and the alkali metal salts, alkaline earth metal salts or ammonium salts thereof, a process for their preparation, their use, veterinary drugs and a process for controlling protozoal diseases.
    Type: Grant
    Filed: March 8, 1985
    Date of Patent: February 3, 1987
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Rosner, Wolfgang Raether
  • Patent number: 4639463
    Abstract: New phenylsulfonyloxybenzimidazolecarbamates of the formula ##STR1## are described, as are processes for their preparation. The new compounds have anthelmintic activity, including, in particular, against liver flukes.
    Type: Grant
    Filed: December 21, 1983
    Date of Patent: January 27, 1987
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Rosner, Heinz Loewe, Dieter Duwel, Reinhard Kirsch
  • Patent number: 4504490
    Abstract: New benzenesulfonic esters of the formula I ##STR1## and a process for their preparation are described. The new compounds are active against helminths and can thus be used as agents to counter worms in humans and animals.
    Type: Grant
    Filed: September 2, 1983
    Date of Patent: March 12, 1985
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Rosner, Josef Urbanietz, Heinz Loewe, Dieter Duwel, Reinhard Kirsch
  • Patent number: 4339618
    Abstract: The invention relates to a process for the production of nitroaryl compounds which are at least monosubstituted, by nitration of aryl compounds which are at least monosubstituted, which process comprises carrying out the nitration in a two-phase system which consists of an inorganic phase consisting of sulfuric acid having a concentration of at least 80% and an organic phase consisting of an inert organic liquid in which the nitration product is almost insoluble in the presence of sulfuric acid, at a temperature in the range from -30.degree. to 100.degree. C., with nitric acid as nitrating agent.The novel process can be generally employed for aryl compounds which are at least monosubstituted. The corresponding nitroaryl compounds are obtained in high yield and isomeric purity.
    Type: Grant
    Filed: June 17, 1980
    Date of Patent: July 13, 1982
    Assignee: Ciba-Geigy AG
    Inventor: Manfred Rosner
  • Patent number: 4288620
    Abstract: A process for the production of 4-acylamido-2-nitro-1-alkoxybenzenes by acylating p-alkoxyaniline with an acylating agent to 4-acylamido-alkoxybenzenes and subsequently nitrating these latter to 4-acylamido-2-nitro-1-alkoxybenzenes, which process comprises carrying out the reaction in an inert solvent, without isolation of the intermediates, using 88 to 95% sulfuric acid in the weight ratio of 6:1 to 10:1, based on the p-alkoxyaniline employed, during the nitration step.
    Type: Grant
    Filed: June 12, 1980
    Date of Patent: September 8, 1981
    Assignee: Ciba-Geigy AG
    Inventor: Manfred Rosner
  • Patent number: 4198407
    Abstract: Novel substituted 2-phenyl-1,2,4-triazine-3,5-(2H,4H)-diones are described as well as a process for their manufacture. The novel compounds may be used as chemotherapeutics, especially as coccidiostatic agents.
    Type: Grant
    Filed: May 16, 1978
    Date of Patent: April 15, 1980
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Rosner, Wolfgang Raether
  • Patent number: 4156778
    Abstract: Substituted bis-benzimidazolyl compounds of the formula ##STR1## are disclosed, wherein A is thiophenediyl, furanediyl, phenylene, or phenoxyphenylene, and R.sup.1 is ##STR2## where R.sup.2 -R.sup.10 are independently hydrogen, alkyl, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, or phenyl, or any two of R.sup.2 -R.sup.10 taken together are C.sub.2 -C.sub.4 alkylene, as are methods of making the compounds, which are useful as chemotherapeutic agents in the treatment of protozoal and viral diseases.
    Type: Grant
    Filed: March 14, 1978
    Date of Patent: May 29, 1979
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Rosner, Heinz Loewe, Wolfgang Raether