Patents by Inventor Manfred Rosner
Manfred Rosner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10421749Abstract: The present invention relates to compounds and compositions for use in methods of treating and/or preventing conditions, disorders or diseases that are mediated or caused by a virus.Type: GrantFiled: April 7, 2016Date of Patent: September 24, 2019Assignees: HELMHOLTZ ZENTRUM MÜNCHEN-DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH), LEIBNIZINSTITUT FÜR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E. V. -HANS-KNÖLL-INSTITUTInventors: Ruth Brack-Werner, Markus Helfer, Manfred Rösner, Martha Schneider, Ulrike Protzer, Christian Hertweck, Martina Werneburg
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Publication number: 20180118725Abstract: The present invention relates to compounds and compositions for use in methods of treating and/or preventing conditions, disorders or diseases that are mediated or caused by a virus.Type: ApplicationFiled: April 7, 2016Publication date: May 3, 2018Inventors: Ruth BRACK-WERNER, Markus HELFER, Manfred RÖSNER, Martha SCHNEIDER, Ulrike PROTZER, Christian HERTWECK, Martina WERNEBURG
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Patent number: 6369057Abstract: Compounds of the formula I or Ia in which n and the substituents R1, R5 and x have the meaning mentioned have an antiviral activity.Type: GrantFiled: April 7, 1995Date of Patent: April 9, 2002Assignee: Aventis Pharma Deutschland GmbHInventors: Uta-Maria Billhardt, Manfred Rösner, Günther Riess, Irvin Winkler, Rudolf Bender
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Patent number: 6114349Abstract: Substituted quinoline derivatives, processes for their preparation, and their use.Compounds of the formula I ##STR1## and their tautomeric forms, of the formula Ia ##STR2## in which m, n and the substituents X and R.sup.1 to R.sup.5 have the meanings mentioned, have an action against viruses.Type: GrantFiled: March 3, 1999Date of Patent: September 5, 2000Assignee: Hoechst AktiengesellschaftInventors: Reinhard Kirsch, Jorg-Peter Kleim, Gunther Riess, Bernd Rosenstock, Manfred Rosner, Irvin Winkler
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Patent number: 5798365Abstract: Compounds of the formula I, ##STR1## and also their tautomeric forms of the formula Ia, ##STR2## in which the substituents R.sup.1 to R.sup.6 and X have said meanings, exhibit antiviral activity.Type: GrantFiled: August 14, 1995Date of Patent: August 25, 1998Assignee: Hoechst AktiengesellschaftInventors: Reinhard Kirsch, Jorg-Peter Kleim, Gunther Riess, Manfred Rosner, Irvin Winkler
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Patent number: 5723461Abstract: Disclosed are quinoxalinone compounds of the formula I or Ia ##STR1## and physiologically tolerated salts and prodrugs thereof, in which n=zero, one or two;R.sup.1 =fluorine, chlorine, hydroxyl or C.sub.1 -C.sub.3 -alkoxy; R.sup.2 =C.sub.1 -C.sub.4 -alkyl which is unsubstituted or is substituted by hydroxyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -alkylthio; R.sup.3 =C.sub.1 -C.sub.6 -alkyloxycarbonyl or C.sub.2 -C.sub.6 -alkenyloxycarbonyl, and X=oxygen, sulfur or selenium, a process for their preparation and pharmaceutical compositions containing the compounds.Type: GrantFiled: October 17, 1995Date of Patent: March 3, 1998Assignee: Hoechst AktiengesellschaftInventors: Manfred Rosner, Uta-Maria Billhardt-Troughton, Reinhard Kirsch, Jorg-Peter Kleim, Christoph Meichsner, Gunther Riess, Irvin Winkler
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Patent number: 5424311Abstract: Compounds of the formula I ##STR1## and their tautomeric form of the formula Ia ##STR2## in which the substituents R.sup.1 to R.sup.5 and V, W, Y and Z have the stated meanings, display an effect against viruses.Type: GrantFiled: September 23, 1993Date of Patent: June 13, 1995Assignee: Hoeschst AktiengesellschaftInventors: Uta-Maria Billhardt-Troughton, Manfred Rosner, Rudolf Bender, Christoph Meichsner
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Patent number: 5188832Abstract: A method of using certain triazine-dione compounds for the control of endo- and ectoparasites of fish and/or insects. The compounds may be combined with aids to form an agent for controlling the endo- or ectoparasites.Type: GrantFiled: February 14, 1990Date of Patent: February 23, 1993Assignee: Hoechst AktiengesellschaftInventors: Heinz Mehlhorn, Horst Taraschewski, Gunter Schmahl, Wolfgang Raether, Manfred Rosner
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Patent number: 4871734Abstract: Thienoimidazole-toluidines of the formula I ##STR1## in which A represents ##STR2## T denotes --S--, --SO-- or --SO.sub.2 --, and R.sup.1 to R.sup.9 have the meanings stated in the description, and a process for their preparation, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion, are described.Type: GrantFiled: November 20, 1987Date of Patent: October 3, 1989Assignee: Hoechst AktiengesellschaftInventors: Hans-Jochen Lang, Manfred Rosner, Weidmann, Klaus, Robert Rippel, Andreas W. Herling
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Patent number: 4782056Abstract: Compounds of the formula I ##STR1## with n=1-3, R=H, Hal, CF.sub.3, alkyl, cycloalkyl, alkyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, benzylsulfinyl, benzylsulfonyl, nitro, cyano, amino, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidinyl, 4-methyl-1-piperazinyl, acylamino or substituted phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, benzoyl, benzoylamino or anilino, with R.sup.2 =H, alkyl, cycloalkyl, optionally substituted benzyl, alkanoyl or benzoyl and R.sup.3 =H, alkyl, cycloalkyl or optionally substituted benzyl, at least R.sup.2 or R.sup.3 not being H, are obtained by alkylation or acylation of a compound II ##STR2## in which R.sup.1 is as defined above, with compounds R.sup.3 X (X=leaving group) or R.sup.2 Y (Y=leaving group), R.sup.2 and R.sup.3 being defined as indicated.Compounds I are coccidiostatics.Type: GrantFiled: September 5, 1986Date of Patent: November 1, 1988Assignee: Hoechst AktiengesellschaftInventors: Manfred Rosner, Wolfgang Raether
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Patent number: 4640917Abstract: Substituted 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones of the formula ##STR1## in which n is one, two or three and the individual substituents R are independently of one another (a) hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl each having 1 to 6 carbon atoms in the alkyl moiety, nitro, cyano, amino, alkylamino or dialkylamino each having 1 to 12 carbon atoms in the alkyl moiety, piperidino, morpholino, thiomorpholino, 1-pyrrolidinyl, 4-methyl-1-piperazinyl or acylamino having 1 to 6 carbon atoms in the acyl moiety, or (b) a phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, benzoyl, benzoylamino or aniline radical which is in each case R.sub.(a) -substituted, and the alkali metal salts, alkaline earth metal salts or ammonium salts thereof, a process for their preparation, their use, veterinary drugs and a process for controlling protozoal diseases.Type: GrantFiled: March 8, 1985Date of Patent: February 3, 1987Assignee: Hoechst AktiengesellschaftInventors: Manfred Rosner, Wolfgang Raether
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Patent number: 4639463Abstract: New phenylsulfonyloxybenzimidazolecarbamates of the formula ##STR1## are described, as are processes for their preparation. The new compounds have anthelmintic activity, including, in particular, against liver flukes.Type: GrantFiled: December 21, 1983Date of Patent: January 27, 1987Assignee: Hoechst AktiengesellschaftInventors: Manfred Rosner, Heinz Loewe, Dieter Duwel, Reinhard Kirsch
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Patent number: 4504490Abstract: New benzenesulfonic esters of the formula I ##STR1## and a process for their preparation are described. The new compounds are active against helminths and can thus be used as agents to counter worms in humans and animals.Type: GrantFiled: September 2, 1983Date of Patent: March 12, 1985Assignee: Hoechst AktiengesellschaftInventors: Manfred Rosner, Josef Urbanietz, Heinz Loewe, Dieter Duwel, Reinhard Kirsch
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Patent number: 4339618Abstract: The invention relates to a process for the production of nitroaryl compounds which are at least monosubstituted, by nitration of aryl compounds which are at least monosubstituted, which process comprises carrying out the nitration in a two-phase system which consists of an inorganic phase consisting of sulfuric acid having a concentration of at least 80% and an organic phase consisting of an inert organic liquid in which the nitration product is almost insoluble in the presence of sulfuric acid, at a temperature in the range from -30.degree. to 100.degree. C., with nitric acid as nitrating agent.The novel process can be generally employed for aryl compounds which are at least monosubstituted. The corresponding nitroaryl compounds are obtained in high yield and isomeric purity.Type: GrantFiled: June 17, 1980Date of Patent: July 13, 1982Assignee: Ciba-Geigy AGInventor: Manfred Rosner
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Patent number: 4288620Abstract: A process for the production of 4-acylamido-2-nitro-1-alkoxybenzenes by acylating p-alkoxyaniline with an acylating agent to 4-acylamido-alkoxybenzenes and subsequently nitrating these latter to 4-acylamido-2-nitro-1-alkoxybenzenes, which process comprises carrying out the reaction in an inert solvent, without isolation of the intermediates, using 88 to 95% sulfuric acid in the weight ratio of 6:1 to 10:1, based on the p-alkoxyaniline employed, during the nitration step.Type: GrantFiled: June 12, 1980Date of Patent: September 8, 1981Assignee: Ciba-Geigy AGInventor: Manfred Rosner
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Patent number: 4198407Abstract: Novel substituted 2-phenyl-1,2,4-triazine-3,5-(2H,4H)-diones are described as well as a process for their manufacture. The novel compounds may be used as chemotherapeutics, especially as coccidiostatic agents.Type: GrantFiled: May 16, 1978Date of Patent: April 15, 1980Assignee: Hoechst AktiengesellschaftInventors: Manfred Rosner, Wolfgang Raether
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Patent number: 4156778Abstract: Substituted bis-benzimidazolyl compounds of the formula ##STR1## are disclosed, wherein A is thiophenediyl, furanediyl, phenylene, or phenoxyphenylene, and R.sup.1 is ##STR2## where R.sup.2 -R.sup.10 are independently hydrogen, alkyl, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, or phenyl, or any two of R.sup.2 -R.sup.10 taken together are C.sub.2 -C.sub.4 alkylene, as are methods of making the compounds, which are useful as chemotherapeutic agents in the treatment of protozoal and viral diseases.Type: GrantFiled: March 14, 1978Date of Patent: May 29, 1979Assignee: Hoechst AktiengesellschaftInventors: Manfred Rosner, Heinz Loewe, Wolfgang Raether