Abstract: A hydrochloride salt of inupadenant, pharmaceutical compositions thereof, methods of making pharmaceutical compositions of a hydrochloride salt of inupadenant (e.g., crystalline hydrochloride salt of inupadenant) and methods of using the pharmaceutical compositions in combination with carboplatin and pemetrexed in the treatment of non-small cell lung cancer (NSCLC), including squamous NSCLC and nonsquamous NSCLC.

Abstract: The present disclosure relates to an arrangement for a motor vehicle including a steering wheel, having an electrode, and evaluation electronics, which are to be protected against an electrical overvoltage and which are electrically conductively connected to the electrode for capacitive detection of a touch on the steering wheel, wherein the steering wheel has a steering wheel rim and an steering wheel core for fixing to a steering wheel shaft, wherein the steering wheel core is electrically conductively connected to a first ground connection via a first ohmic resistor, wherein the evaluation electronics are configured to apply an electrical measuring potential to the electrode to detect a touch on the steering wheel rim from; wherein the evaluation electronics are electrically conductively connected to a second ground connection; an electrically conductive connection provided between the electrode and the steering wheel core, which connection has an overvoltage discharge element.

Abstract: A stick-slip piezo motor. At least one voltage source is connected to a piezo motor. The piezo motor has at least one oscillating piezo element and at least one moving friction element connected to the oscillating piezo element. The moving friction element moves in a desired travel direction. A computer is programmed to control the voltage source to deliver voltage to the piezo motor at a predetermined frequency and amplitude to control the speed of the piezo motor. The computer is programmed to hold the frequency constant while varying the amplitude to adjust the speed of the piezo motor. In a preferred embodiment the computer is programmed to hold the frequency constant at an ultrasonic frequency. In another preferred embodiment the computer is programmed to hold the frequency constant at a value of 15 kHz or higher.

Abstract: The present invention relates to thiocarbamate derivatives of Formula (I) which are useful as A2A adenosine receptor (A2AR) inhibitors. Especially, the present invention relates to methods and formulations for treating and/or preventing cancers in a subject with a pharmaceutical composition comprising a thiocarbamate derivative as adenosine A2A receptor inhibitor. The pharmaceutical composition of the invention is particularly useful for oral dosing in the treatment of cancer.

Abstract: A circuit structure and a method for carrying out an alternating heating and capacitive measuring mode by a common heating wire is presented. The method includes carrying out a heating mode, during which from a switching by a control circuit switching elements are in a conducting state, the switching elements are connected in series, so that the heating wire is supplied with a heating current from two different heating potentials; triggering a change into a detecting mode by the control circuit, so that the switching elements switch from the heating mode into a measuring mode, during which the switching elements are in a blocking state, so that the two different heating potentials are each interrupted several times; carrying out the measuring mode, in which the capacitance of the heating wire relative to a reference potential is determined by a detecting circuit by applying to the heating wire an alternating voltage.

Abstract: A stick-slip piezo motor. At least one voltage source is connected to a piezo motor. The piezo motor has at least one oscillating piezo element and at least one moving friction element connected to the oscillating piezo element. The moving friction element moves in a desired travel direction. A computer is programmed to control the voltage source to deliver voltage to the piezo motor at a predetermined frequency and amplitude to control the speed of the piezo motor. The computer is programmed to hold the frequency constant while varying the amplitude to adjust the speed of the piezo motor. In a preferred embodiment the computer is programmed to hold the frequency constant at an ultrasonic frequency. In another preferred embodiment the computer is programmed to hold the frequency constant at a value of 15 kHz or higher.

Abstract: A steering wheel for a motor vehicle is presented. The steering wheel includes a steering wheel hub configured for the detachable attachment to a steering shaft of the motor vehicle; a steering wheel rim fixed to the steering wheel hub; at least one electrode, which is integrated into the steering wheel rim, for the capacitive detection of a touch on the steering wheel rim; an electrically conductive connection disposed outside the steering wheel to apply an electrical measuring potential for touch detection to the electrode, and to detect the touch on the steering wheel rim; a non-volatile data storage unit on or in the steering wheel, wherein the non-volatile data storage unit is in each case configured or developed to be read out by a reading unit disposed outside the steering wheel and connected to the electronic evaluation unit in a data-transmitting manner.

Abstract: A method for automated alignment and register measurement in a printing press provides for test patterns having multiple color separations to be printed by the printing press on a printing substrate, recorded by using at least one image sensor of an image acquisition system as a digital overall image, evaluated by a computer with respect to an alignment/register offset and then corrected by the computer for the alignment/register offset. Circular measuring marks having known diameter for each color separation are integrated into the test patterns and the computer ascertains the center position of each circular measuring mark with subpixel accuracy and thus computes the alignment/register offset by cutting out an image region having at least one circular measuring mark from the digital overall image and determining parameters of a model of a printing point of the circular measuring mark from the digital overall image.

Abstract: A stick-slip piezo motor. At least one voltage source is connected to a piezo motor. The piezo motor has at least one oscillating piezo element and at least one moving friction element connected to the oscillating piezo element. The moving friction element moves in a desired travel direction. A computer is programmed to control the voltage source to deliver voltage to the piezo motor at a predetermined frequency and amplitude to control the speed of the piezo motor. The computer is programmed to hold the frequency constant while varying the amplitude to adjust the speed of the piezo motor. In a preferred embodiment the computer is programmed to hold the frequency constant at an ultrasonic frequency. In another preferred embodiment the computer is programmed to hold the frequency constant at a value of 15 kHz or higher.

Abstract: A method for automated alignment and register measurement in a printing press provides for test patterns having multiple color separations to be printed by the printing press on a printing substrate, recorded by using at least one image sensor of an image acquisition system as a digital overall image, evaluated by a computer with respect to an alignment/register offset and then corrected by the computer for the alignment/register offset. Circular measuring marks having known diameter for each color separation are integrated into the test patterns and the computer ascertains the center position of each circular measuring mark with subpixel accuracy and thus computes the alignment/register offset by cutting out an image region having at least one circular measuring mark from the digital overall image and determining parameters of a model of a printing point of the circular measuring mark from the digital overall image.

Abstract: A method for the automated calibration of a printing machine with an image capture system by using a computer, includes putting at least one printed sample substrate with defined deviations into the printing machine, generating a digital image of the printed sample substrate by using the image capture system, calculating current compensation values including defined deviations for configuration parameters of the printing machine relating to optimizing the printing quality by using the computer, and comparing the current compensation values created with target compensation values known from the defined deviations of the printed sample substrate. Serviceability of the printing machine is checked by evaluating the comparison by the computer and/or calibrating the printing machine by using the evaluated comparison by the computer.

Abstract: A method for the automated calibration of a printing machine with an image capture system by using a computer, includes putting at least one printed sample substrate with defined deviations into the printing machine, generating a digital image of the printed sample substrate by using the image capture system, calculating current compensation values including defined deviations for configuration parameters of the printing machine relating to optimizing the printing quality by using the computer, and comparing the current compensation values created with target compensation values known from the defined deviations of the printed sample substrate. Serviceability of the printing machine is checked by evaluating the comparison by the computer and/or calibrating the printing machine by using the evaluated comparison by the computer.

Abstract: An ink control method is provided for printing machines having a computer. The color areas are scanned on a surface to be printed using a color measuring device. The surface is a printing substrate coated with opaque white, and the color measuring device takes a number of opaque white color measurements. The computer compares the measured opaque white color values to each other or to a reference color value of the opaque white and stores deviations detected in the computer. The color measurement fields are printed onto the printing substrate. The color measurement fields printed onto the opaque white are measured by the color measuring device. The comparison of the measured color values of the color measurement fields under laid with opaque white and the target color values of the original for color control purposes, the computer factors in the influence of the stored detected deviations.

Abstract: An ink control method is provided for printing machines having a computer. The color areas are scanned on a surface to be printed using a color measuring device. The surface is a printing substrate coated with opaque white, and the color measuring device takes a number of opaque white color measurements. The computer compares the measured opaque white color values to each other or to a reference color value of the opaque white and stores deviations detected in the computer. The color measurement fields are printed onto the printing substrate. The color measurement fields printed onto the opaque white are measured by the color measuring device. The comparison of the measured color values of the color measurement fields under laid with opaque white and the target color values of the original for color control purposes, the computer factors in the influence of the stored detected deviations.

Abstract: A color measurement on printed materials produced by a printing press is performed by at least a first color measuring device installed in the printing press and at least a second color measuring device. A signal is output by the first color measuring device in the printing press when the measured color values registered on the printing materials are located within a predefined tolerance limit for a predefined period and that, after the signal has been output, a color measurement on one of the printed materials thus produced is performed with the second color measuring device.

Abstract: A method for color control in printing presses having at least one first color measuring instrument and at least one second color measuring instrument, includes registering at least one first inking zone on a printing material with the first color measuring instrument and registering at least one other, second inking zone on the printing material with the second color measuring instrument. In a first step, a color difference between actual colorations of the first and second inking zones is calculated, in a second step, a color difference between an actual coloration of the first inking zone and a desired coloration of the second inking zone is calculated and, in a further step, the calculated color differences are added and supplied to a color control for the second inking zone.

Abstract: A stick-slip piezo motor. A piezo housing holds at least two piezo elements. The piezo elements are both rigidly connected to the piezo housing. At the end of each of the piezo elements is a piezo friction element. Each of the piezo friction elements is in friction contact with a moving friction element. While oscillating between a stick phase and a slip phase, both of the friction elements operate in conjunction to move the moving friction element in a desired travel direction. The piezo elements oscillate out of phase such that when one of the oscillating piezo elements is operating in the slip phase and moving in a direction opposite to the desired travel direction, the other oscillation piezo element is operating in the stick phase and is moving in the travel direction in order to counteract and overcome unwanted dragging of the moving piezo element.

Abstract: A suction belt (1) for transporting tobacco in the manufacture of cigarettes has a fabric (5) comprising warp threads (6) and weft threads (7), the ends (2,3) of which suction belt are connected in a connecting region (4) to form a continuous suction belt (1). The weft threads (7) and/or the warp threads (6), at least in the connecting region (4), have a light-absorbing material (8). The continuous suction belt (1) is laser welded in the connecting region (4).

Abstract: A device for positioning a measuring head above a print substrate includes a display device and a motor-driven positioning device for the measuring head. The motor-driven positioning device for the measuring head is controllable by a computer connected to the display device. Measurement locations are selectable on the display device and the measuring head is positioned by the positioning device depending on the selected measurement locations.

Abstract: A method for controlling color in printing technology machines, includes measuring color measured values without/with a UV filter and converting them with a computer to color measured values measured with/without a UV filter. The color measured values measured without/with a UV filter are recorded by a color measurement instrument on a substrate. The spectral remission values of the substrate measured with and without a UV filter are supplied to the computer and the computer converts color measured values measured without/with a UV filter to color measured values measured with/without a UV filter taking into account these supplied spectral remission values of the substrate, and uses them to control the color in the printing technology machine. A printing technology machine having a computer for carrying out the method, is also provided.