Patents by Inventor Manfred Schudok

Manfred Schudok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic and heterocyclic N-substituted &agr;-iminohydroxamic and carboxyclic acids
    Patent number: 6207672
    Abstract: Compounds of the formula I are suitable for preparing pharmaceuticals for the treatment of disorders in the course of which is involved an increased activity of matrix-degrading metalloproteinases.
    Type: Grant
    Filed: March 9, 1999
    Date of Patent: March 27, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Werner Thorwart, Wilfried Schwab, Manfred Schudok, Burkhard Haase, Eckart Bartnik, Klaus-Ulrich Weithmann
  • N-arylsulfonylamino acid omega-amides
    Patent number: 6201130
    Abstract: Compounds of the formula I: stereoisomeric forms, and physiologically tolerable salts thereof are suitable for the production of pharmaceuticals for the therapy and prophylaxis of disorders involving matrix-degrading metalloproteinases.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: March 13, 2001
    Assignee: Aventis Pharma Duetschland GmbH
    Inventors: Wilfried Schwab, Werner Thorwart, Manfred Schudok, Burkhard Haase
  • Substituted diaminocarboxylic acids
    Patent number: 6159995
    Abstract: Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: December 12, 2000
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Werner Thorwart, Wilfried Schwab, Manfred Schudok, Burkhard Haase, Bernhard Neises, Gunter Billen
  • Substituted 6- and 7-aminotetrahydroisoquinolinecarboxylic acids
    Patent number: 5962471
    Abstract: Compounds of the formula I ##STR1## are suitable for the preparation of pharmaceuticals for the prophylaxis and therapy of disorders involving increased activity of matrix-degrading metalloproteinases.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: October 5, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Manfred Schudok
  • Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids and their use
    Patent number: 5780640
    Abstract: Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids, and their use.L-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 14, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Kretzschmar, Johannes Meiwes, Manfred Schudok, Peter Hammann, Ulrich Lerch, Susanne Grabley
  • Process for enzymatic acylation of alcohols with alkoxyvinyl acetates by transesterification
    Patent number: 5756321
    Abstract: Methods for the enzyme catalyzed acylation of primary and secondary alcohols using an enol ester as the acyl donor are described. The acylation occurs in organic media, and is enantioselective for racemic or prochiral alcohols. The reaction is irreversible, and produces unreactive by-products.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: May 26, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Schudok, Gerhard Kretzschmar
  • Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids
    Patent number: 5688672
    Abstract: Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acidsL-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 18, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Kretzschmar, Johannes Meiwes, Manfred Schudok, Peter Hammann, Ulrich Lerch, Susanne Grabley
  • Process for the biotechnological preparation of l-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids, and their use
    Patent number: 5480786
    Abstract: L-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.
    Type: Grant
    Filed: July 29, 1993
    Date of Patent: January 2, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Kretzschmar, Johannes Meiwes, Manfred Schudok, Peter Hammann, Ulrich Lerch, Susanne Grabley
  • Acylation of alcohols with Pseudomonas lipase immobilized on a polystyrene resin
    Patent number: 5387514
    Abstract: The O-acylation of alcohols is carried out by reacting a vinyl ester or a carboxylic ester with Pseudomonas lipase immobilized on a hydrophobic carrier such as a polystyrene-based carrier. The polystyrene carrier preferably has a surface area of 100-1000 m.sup.2 /g, a pore volume of 25 to 75% and a pore diameter of 25-1200 .ANG.. Crosslinking may be carried out after the lipase is immobilized on the carrier.
    Type: Grant
    Filed: December 28, 1993
    Date of Patent: February 7, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Schudok, Gerd Fulling, Gerhard Kretzschmar
  • Process for the glycosidase-catalyzed synthesis of glyco conjugates
    Patent number: 5262312
    Abstract: It has been possible to show for a first time with the process according to the invention that the synthesis of glyco conjugates is possible by direct linkage of sugars with serine, serine derivatives and serine peptides with the aid of glucosidases.
    Type: Grant
    Filed: April 23, 1991
    Date of Patent: November 16, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wolfgang Holla, Manfred Schudok