Patents by Inventor Manfred Uhr

Manfred Uhr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymorphisms in ABCB1 associated with a lack of clinical response to medicaments
    Patent number: 9901582
    Abstract: The present invention relates to methods, compositions, kits and reagents for determining the prognosis of a clinical response in a human patient to a medicament which acts in the central nervous system (CNS) and which is a substrate of the ABCB1 protein. Further, the invention relates to a combination of medicaments for the treatment of human patients having specific polymorphisms in the ABCB1 gene.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: February 27, 2018
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.
    Inventors: Manfred Uhr, Florian Holsboer, Bertram Müller-Myhsok
  • NEW POLYMORPHISMS IN ABCB1 ASSOCIATED WITH A LACK OF CLINICAL RESPONSE TO MEDICAMENTS
    Publication number: 20160067262
    Abstract: The present invention relates to methods, compositions, kits and reagents for determining the prognosis of a clinical response in a human patient to a medicament which acts in the central nervous system (CNS) and which is a substrate of the ABCB1 protein. Further, the invention relates to a combination of medicaments for the treatment of human patients having specific polymorphisms in the ABCB1 gene.
    Type: Application
    Filed: July 16, 2015
    Publication date: March 10, 2016
    Applicant: Max-Planck-Gesellschaft zur Förderung der Wisenschaften e. V.
    Inventors: Manfred Uhr, Florian Holsboer, Bertram Müller-Myhsok
  • Polymorphisms in ABCB1 associated with a lack of clinical response to medicaments
    Patent number: 9115398
    Abstract: The present invention relates to methods, compositions, kits and reagents for determining the prognosis of a clinical response in a human patient to a medicament which acts in the central nervous system (CNS) and which is a substrate of the ABCB1 protein. Further, the invention relates to a combination of medicaments for the treatment of human patients having specific polymorphisms in the ABCB1 gene.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: August 25, 2015
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wisenschaften e.V.
    Inventors: Manfred Uhr, Florian Holsboer, Bertram Müller-Myhsok
  • Methods for predicting the response of multiple sclerosis patients to interferon therapy and diagnosing multiple sclerosis
    Patent number: 8071299
    Abstract: The present invention relates to a method of diagnosing a predisposition of a multiple sclerosis (MS) patient for responsiveness to a treatment of MS by administration of interferon-? (IFN-?) and/or interferon-? (IFN-?) and means to perform the method. Furthermore, the invention relates to a method of diagnosing a predisposition of a patient for developing multiple sclerosis (MS) and corresponding means.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: December 6, 2011
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Frank Weber, Bertram Muller-Myhsok, Manfred Uhr, Susanne Lucae, Daria Salyakina, Florian Holsboer
  • Polymorphisms in ABCB1 associated with a lack of clinical response to medicaments
    Patent number: 8030033
    Abstract: The present invention relates to methods, compositions and kits for determining the prognosis of a clinical response in a human patient to a medicament which acts in the central nervous system and which is a substrate of the ABCB1 protein. Further, the invention relates to a combination of medicaments for the treatment of human patients having specific polymorphisms in the ABCB1 gene.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: October 4, 2011
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenshaften e.V.
    Inventors: Manfred Uhr, Florian Holsboer, Elisabeth Binder, Bertram Mueller-Myhsok
  • USE OF POLYMORPHISMS IN THE TMEM132D GENE IN THE PREDICTION AND TREATMENT OF ANXIETY DISORDERS
    Publication number: 20100216653
    Abstract: The present invention relates to methods, compositions, kits and reagents for the diagnosis and treatment of anxiety disorders.
    Type: Application
    Filed: October 2, 2008
    Publication date: August 26, 2010
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V
    Inventors: Bertram Mueller-Myhsok, Angelika Erhardt, Manfred Uhr, Thomas Bettecken, Florian Holsboer
  • POLYMORPHISMS IN ABCB1 ASSOCIATED WITH A LACK OF CLINICAL RESPONSE TO MEDICAMENTS
    Publication number: 20100184742
    Abstract: The present invention relates to methods, compositions, kits and reagents for determining the prognosis of a clinical response in a human patient to a medicament which acts in the central nervous system (CNS) and which is a substrate of the ABCB1 protein. Further, the invention relates to a combination of medicaments for the treatment of human patients having specific polymorphisms in the ABCB1 gene.
    Type: Application
    Filed: June 12, 2008
    Publication date: July 22, 2010
    Inventors: Manfred Uhr, Florian Holsboer, Bertram Müller-Myhsok
  • Methods For Predicting The Response Of Multiple Sclerosis Patients To Interferon Theraphy And Diagnosing Multiple Sclerosis
    Publication number: 20090186773
    Abstract: The present invention relates to a method of diagnosing a predisposition of a multiple sclerosis (MS) patient for responsiveness to a treatment of MS by administration of interferon-? (IFN-?) and/or interferon-? (IFN-?) and means to perform the method. Furthermore, the invention relates to a method of diagnosing a predisposition of a patient for developing multiple sclerosis (MS) and corresponding means.
    Type: Application
    Filed: February 27, 2007
    Publication date: July 23, 2009
    Applicant: Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V.
    Inventors: Frank Weber, Bertram Muller-Myhsok, Manfred Uhr, Susanne Lucae, Daria Salyakina, Florian Holsboer
  • Polymorphisms in Abcb1 Associated with a Lack of Clinical Response to Medicaments
    Publication number: 20080064609
    Abstract: The present invention relates to methods, compositions and kits for determining the prognosis of a clinical response in a human patient to a medicament which acts in the central nervous system and which is a substrate of the ABCB1 protein. Further, the invention relates to a combination of medicaments for the treatment of human patients having specific polymorphisms in the ABCB1 gene.
    Type: Application
    Filed: May 12, 2005
    Publication date: March 13, 2008
    Applicant: Max-Planck-Gesellschft Zur Foerderung Der Wissenschaften e.V.
    Inventors: Manfred Uhr, Florian Holsboer, Elisabeth Binder, Bertram Mueller-Myhsok
  • Novel Target for Antiderpressant Therapy
    Publication number: 20070298027
    Abstract: The present invention relates to a method of classifying an individual comprising analyzing the nucleic acid of a sample taken from said patient for nucleotide polymorphisms in a haplotype block comprising the gene encoding FKBP51 and/or determining the expression level of FKBP51 in said sample. In a preferred embodiment, the invention provides a method of predicting the response to antidepressant therapy. Furthermore, a method of developing an anti-depressant drug, and pharmaceutical compositions are provided.
    Type: Application
    Filed: September 28, 2004
    Publication date: December 27, 2007
    Applicant: Max-Planck-Gesellschaft zur Forderung der Wissensc
    Inventors: Elisabeth Binder, Florian Holsboer, Theo Rein, Gabriele Wochnik, Bertram Muller-Myhsok, Manfred Uhr