Patents by Inventor Manfred Worm

Manfred Worm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 4-(4-(4-(hydroxybiphenyl)-1-piperidinyl)-1-hydroxybutyl)-.alpha.,.alpha. -dimethylphenylacetic acid and phosphorylated derivatives
    Patent number: 5990127
    Abstract: The invention relates to the preparation of the compound 4-(4-(4-(hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-.alpha.,.alpha.-d imethylphenylacetic acid and its phosphorylated derivatives. These compounds can be prepared from .alpha.-(p-tert-butylphenyl)-4-(.alpha.-hydroxy-.alpha.-phenylbenzyl)-1-pi peridinylbutanol with the aid of fungi of the genus Cunninghamella or Absidia. The compounds according to the present invention can be used as pharmaceuticals for the treatment of allergic disorders, allergic rhinitis or asthma. Compounds of the formula II in which R.sup.1 is --CH.sub.2 --O--P(O)(OH).sub.2 and R.sup.2 is --OH; R.sup.1 is --CH.sub.3 and R.sup.2 is --O--P(O)(OH).sub.2 ; orR.sup.1 is --COOH and R.sup.2 is --O--P(O)(OH).sub.2 are produced by the process according to the present invention and are suitable as pharmaceuticals with antihistamine action.
    Type: Grant
    Filed: March 9, 1998
    Date of Patent: November 23, 1999
    Assignee: Hoechst Marion Roussel Deutschland GmbH
    Inventors: Johannes Meiwes, Manfred Worm
  • 4-phenyl-1,3-benzodiazepines and 2-amino-.alpha.-phenylphenethylamines for treating convulsions and protecting neurons
    Patent number: 5260339
    Abstract: Novel 4-phenyl-1,3-benzodiazepines and 2-amino-.alpha.-phenylphenethylamines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants. The 2-amino-.alpha.-phenylphenethylamines are useful as anticonvulsant and neuroprotective agents.
    Type: Grant
    Filed: October 8, 1992
    Date of Patent: November 9, 1993
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • Carboxamides of 2-amino-alpha-phenlphenethylamines
    Patent number: 5185465
    Abstract: Novel 4-phenyl-1,3-benzodiazepines and 2-amino-.alpha.-phenylphenethylamines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants. The 2-amino-.alpha.-phenylphenethylamines are useful as anticonvulsant and neuroprotective agents.
    Type: Grant
    Filed: October 16, 1990
    Date of Patent: February 9, 1993
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • 2-amino-alpha-phenylphenethylamines and method of use
    Patent number: 4968721
    Abstract: Novel 4-phenyl-1,3-benzodiazepines and 2-amino-.alpha.-phenylphenethylamines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants. The 2-amino-.alpha.-phenylphenethylamines are useful as anticonvulsant and neuroprotective agents.
    Type: Grant
    Filed: January 4, 1989
    Date of Patent: November 6, 1990
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • Intermediates for the preparation of 4-phenyl-1,3-benzodiazepines
    Patent number: 4933493
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: April 6, 1989
    Date of Patent: June 12, 1990
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • Process for the preparation of cefodizime
    Patent number: 4868295
    Abstract: A process for the preparation of cefodizime of the formula ##STR1## wherein (a) a compound of the formula II (ATS) ##STR2## wherein R.sub.1 represents hydrogen or an aminoprotective group and A represents a hydrogen atom or one equivalent of an alkali metal or alkaline earth metal, of ammonium or of an organic nitrogen base, is first reacted with a compound of the formula IIIR--SO.sub.2 Halwherein R represents an optionally substituted alkyl, aryl or aralkyl radical and Hal represents a halogen atom, in an organic solvent and, if appropriate, in the presence of a base,(b) a compound of the formula I (TACS) ##STR3## in which A has the above meaning, is reacted with a silylating agent in an organic solvent and, if appropriate, in the presence of a base, and(c) the two products formed in (a) and (b) are reacted in their reaction solutions, and any protective group R.sub.1 present in the end product of the formula I is eliminated.
    Type: Grant
    Filed: December 1, 1986
    Date of Patent: September 19, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ottmar Jaenicke, Hans Wagner, Manfred Worm
  • .alpha.-(2-nitro-phenylmethyl)-benzylamines
    Patent number: 4855502
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: August 27, 1982
    Date of Patent: August 8, 1989
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crishlow
  • 2-amino-N-methyl-.alpha.-phenyl-phenethylamines
    Patent number: 4822914
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: August 27, 1982
    Date of Patent: April 18, 1989
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • 4-Phenyl-1,3-benzodiazepines
    Patent number: 4504680
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: October 12, 1983
    Date of Patent: March 12, 1985
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • 2-(2-Nitrophenyl)-1-phenylethanone oxime acetates
    Patent number: 4469889
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: October 12, 1983
    Date of Patent: September 4, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals, Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • Process for preparing 4-phenyl-1,3-benzodiazepines
    Patent number: 4462933
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: July 31, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals, Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • Process for preparing 4-phenyl-1,3-benzodiazepines
    Patent number: 4459231
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: July 10, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals, Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • Process for preparing 4-phenyl-1,3-benzodiazepines
    Patent number: 4459230
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: July 10, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals, Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • Process for preparing 4-phenyl-1,3-benzodiazepines
    Patent number: 4409145
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: October 11, 1983
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • (Arylmethyl)phenyl-aminocyclohexanols, cyclohexenes and intermediates thereof
    Patent number: 4313959
    Abstract: (Arylmethyl)phenyl-aminocyclohexanols, (arylmethyl)phenyl aminocyclohexenes and (arylmethyl)phenyl-aminocyclohexanes and methods of preparing same are described. These compounds are useful as antidepressants and anticonvulsants.Compounds 8-[2-(phenylmethyl)phenyl]-1,4-dioxaspiro[4,5]-decan-8-ol, 1-[2-(phenylmethyl)phenyl]-4-oxocyclohexanol, and 1-[2-(phenylmethyl)phenyl]-4-oxocyclohexanol oxime, and methods of preparing same are also described. These compounds are useful as intermediates for preparing the antidepressant and anticonvulsant compounds.
    Type: Grant
    Filed: April 27, 1981
    Date of Patent: February 2, 1982
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Lawrence L. Martin, Manfred Worm
  • 4-Phenyl-1,3-benzodiazepines
    Patent number: 4309424
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: January 5, 1982
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • 1-[2-(4,5-Dihydro-4,4- dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol
    Patent number: 4301292
    Abstract: 1-[2-(4,5-dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexan ol as an intermedate for Spiro cyclohexane-1,1'(3'H)-isobenzofuran)s, which in turn are useful as antidepressants, tranquilizers, analgesics, and anticonvulsants.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: November 17, 1981
    Assignee: Hoechst-Roussel Pharmaceuticals, Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm
  • 3"-Phenyldispiro[1,3-dioxolane-2,4'-cyclohexane-1',1"-(3"H)-isobenzofuran]
    Patent number: 4292243
    Abstract: Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as anti-depressants, tranquilizers, analgesics and anticonvulsants.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: September 29, 1981
    Assignee: Hoechst Roussel Pharmaceuticals Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm
  • 3'-Phenylspiro[cyclohexane-1,1'(3'H)-isobenzofuran]-4-one
    Patent number: 4292245
    Abstract: Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as anti-depressants, tranquilizers, analgesics and anticonvulsants.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: September 29, 1981
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm
  • Process for preparing 4-phenyl-1,3-benzodiazepines
    Patent number: RE32444
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: June 23, 1987
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow