Patents by Inventor Manfred Worms

Manfred Worms has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-amino-N-methyl-.alpha.-phenyl-phenethylamines
    Patent number: 4822914
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: August 27, 1982
    Date of Patent: April 18, 1989
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • 4-Phenyl-1,3-benzodiazepines
    Patent number: 4504680
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: October 12, 1983
    Date of Patent: March 12, 1985
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • 2-(2-Nitrophenyl)-1-phenylethanone oxime acetates
    Patent number: 4469889
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: October 12, 1983
    Date of Patent: September 4, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals, Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • Process for preparing 4-phenyl-1,3-benzodiazepines
    Patent number: 4462933
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: July 31, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals, Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • Process for preparing 4-phenyl-1,3-benzodiazepines
    Patent number: 4459230
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: July 10, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals, Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • Process for preparing 4-phenyl-1,3-benzodiazepines
    Patent number: 4459231
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: July 10, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals, Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • Process for preparing 4-phenyl-1,3-benzodiazepines
    Patent number: 4409145
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: October 11, 1983
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • (Arylmethyl)phenyl-aminocyclohexanols, cyclohexenes and intermediates thereof
    Patent number: 4313959
    Abstract: (Arylmethyl)phenyl-aminocyclohexanols, (arylmethyl)phenyl aminocyclohexenes and (arylmethyl)phenyl-aminocyclohexanes and methods of preparing same are described. These compounds are useful as antidepressants and anticonvulsants.Compounds 8-[2-(phenylmethyl)phenyl]-1,4-dioxaspiro[4,5]-decan-8-ol, 1-[2-(phenylmethyl)phenyl]-4-oxocyclohexanol, and 1-[2-(phenylmethyl)phenyl]-4-oxocyclohexanol oxime, and methods of preparing same are also described. These compounds are useful as intermediates for preparing the antidepressant and anticonvulsant compounds.
    Type: Grant
    Filed: April 27, 1981
    Date of Patent: February 2, 1982
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Lawrence L. Martin, Manfred Worm
  • 4-Phenyl-1,3-benzodiazepines
    Patent number: 4309424
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: January 5, 1982
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
  • 1-[2-(4,5-Dihydro-4,4- dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol
    Patent number: 4301292
    Abstract: 1-[2-(4,5-dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexan ol as an intermedate for Spiro cyclohexane-1,1'(3'H)-isobenzofuran)s, which in turn are useful as antidepressants, tranquilizers, analgesics, and anticonvulsants.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: November 17, 1981
    Assignee: Hoechst-Roussel Pharmaceuticals, Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm
  • 3"-Phenyldispiro[1,3-dioxolane-2,4'-cyclohexane-1',1"-(3"H)-isobenzofuran]
    Patent number: 4292243
    Abstract: Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as anti-depressants, tranquilizers, analgesics and anticonvulsants.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: September 29, 1981
    Assignee: Hoechst Roussel Pharmaceuticals Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm
  • 3'-Phenylspiro[cyclohexane-1,1'(3'H)-isobenzofuran]-4-one
    Patent number: 4292245
    Abstract: Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as anti-depressants, tranquilizers, analgesics and anticonvulsants.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: September 29, 1981
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Lawrence L. Martin, Manfred Worm
  • Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
    Patent number: 4290958
    Abstract: Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as antidepressants, tranquilizers, analgesics and anticonvulsants.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: September 22, 1981
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Lawrence L. Martin, Manfred Worm
  • 1-Aryl-4-amino-cyclohexan-1-ols
    Patent number: 4288623
    Abstract: Sprio[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as anti-depressants, tranquilizers, analgesics and anticonvulsants.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: September 8, 1981
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Lawrence L. Martin, Manfred Worm
  • Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
    Patent number: 4263317
    Abstract: Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as antidepressants, tranquilizers, analgesics and anticonvulsants.
    Type: Grant
    Filed: September 6, 1979
    Date of Patent: April 21, 1981
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Lawrence L. Martin, Manfred Worm
  • 7[(2-Amino-thiazol-4-yl)glyoxylamido]-cephem derivatives and processes for their preparation
    Patent number: 4201779
    Abstract: Cephem derivatives of the formula ##STR1## in which R.sup.1 denotes hydrogen or low-molecular alkoxy, R.sup.2 denotes hydrogen, optionally substituted alkyl, phthalide or a cation, X denotes sulfur, oxygen or CH.sub.2 and A denotes hydrogen, alkoxy, halogen or a group --CH.sub.2 Y, in which Y represents hydrogen, acyloxy, alkoxy, optionally substituted carbamoyloxy or a group --SR.sup.3, in which R.sup.3 can represent acyl, alkyl or an optionally substituted 5-membered or 6-membered heterocyclic structure are disclosed as valuable antibiotics which are well suited for combating Gram-positive and in particular Gram-negative infections and also have an unexpectedly good action against penicillinase-forming staphylococci.
    Type: Grant
    Filed: March 9, 1978
    Date of Patent: May 6, 1980
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dieter Bormann, Bernd Knabe, Elmar Schrinner, Manfred Worm
  • Acylamino-cephem-carboxylic acids containing an amidino or guanidino group in the molecule
    Patent number: 4016159
    Abstract: Acylamino-cephem-carboxylic acids of the formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 represent hydrogen or alkyl, R.sup.1 and R.sup.2 or R.sup.2 and R.sup.3 together may form an alkylene radical which may be substituted, X represents a single bond or NH, A represents a phenylene or thienylene radical which may be substituted, Y represents a single bond or oxygen and Z represents a 5- or 6-membered ring which may be substituted and which may be bound to an anellated ring system, and their physiologically tolerated salts and esters, a process for preparing these compounds and preparations containing them.
    Type: Grant
    Filed: November 27, 1974
    Date of Patent: April 5, 1977
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dieter Bormann, Bernd Knabe, Elmar Schrinner, Manfred Worm
  • Process for preparing 4-phenyl-1,3-benzodiazepines
    Patent number: RE32444
    Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: June 23, 1987
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow