Patents by Inventor Mang Yu
Mang Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8084036Abstract: The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. The invention provides compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. The invention also provides compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.Type: GrantFiled: November 21, 2003Date of Patent: December 27, 2011Assignee: NexBio, Inc.Inventors: Mang Yu, Fang Fang, Michael Malakhov
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Publication number: 20080075708Abstract: Provided are new compositions and methods for preventing and treating pathogen infection. In particular, provided are compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. Also provided are compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. Also provided are compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.Type: ApplicationFiled: August 15, 2007Publication date: March 27, 2008Inventors: Mang Yu, Fang Fang
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Publication number: 20050004020Abstract: The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. The invention provides compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. The invention also provides compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.Type: ApplicationFiled: November 21, 2003Publication date: January 6, 2005Inventors: Mang Yu, Fang Fang
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Patent number: 6458567Abstract: This invention provides ribozymes useful to treat or prevent Hepatitis C Virus (“HCV”) infection or disease in an organism or subject, as well as methods of treating an HCV infection or disease. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes usefull in methods of treatment and prevention of HCV infection or disease are also provided.Type: GrantFiled: November 1, 1999Date of Patent: October 1, 2002Assignee: Immusol, Inc.Inventors: Jack R. Barber, Peter J. Welch, Richard Tritz, SoonPin Yei, Mang Yu
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Patent number: 6132962Abstract: This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent or a foreign nucleic acid under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.Type: GrantFiled: June 16, 1997Date of Patent: October 17, 2000Assignee: The Regents of the University of CaliforniaInventors: Flossie Wong-Staal, Mang Yu, Osamu Yamada, Joshua O. Ojwang, Markley C. Leavitt, Anthony Ho
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Patent number: 6043077Abstract: This invention provides ribozymes useful to treat or prevent Hepatitis C Virus ("HCV") infection or disease in an organism or subject, as well as methods of treating an HCV infection or disease. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes useful in methods of treatment and prevention of HCV infection or disease are also provided.Type: GrantFiled: October 20, 1997Date of Patent: March 28, 2000Assignee: Immusol Inc.Inventors: Jack R. Barber, Peter J. Welch, Richard Tritz, SoonPin Yei, Mang Yu
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Patent number: 5958768Abstract: Methods and compositions for the treatment and diagnosis of infections of Rev-binding primate lentiviruses are provided. These methods and compositions utilize the ability of Rev binding nucleic acids such as the SLII sequence from the HIV-1 Rev response element (RRE) to target therapeutic agents to the same sub-cellular location as primate lentiviruses which contain RRE sequences. In particular, the invention provides trans-acting ribozymes comprising Rev-binding nucleic acids less toxic than a full-length RRE, and molecules encoding them. The use of the compositions of the invention as components of diagnostic assays, as prophylactic reagents, and in vectors is also described.Type: GrantFiled: August 23, 1996Date of Patent: September 28, 1999Assignee: The Regents of the University of CaliforniaInventors: Gunter Kraus, Flossie Wong-Staal, Mang Yu, Osamu Yamada
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Patent number: 5939538Abstract: Methods of inhibiting HIV infection by blocking HIV co-receptor RNA expression are provided. Ribozymes which cleave HIV co-receptor RNA and inhibit HIV infection of cells are also provided. Co-receptor targets include fusin and CKR5.Type: GrantFiled: December 19, 1996Date of Patent: August 17, 1999Assignee: Immusol IncorporatedInventors: Markley C. Leavitt, Richard Tritz, Yu Feng, Jack Barber, Mang Yu
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Patent number: 5811275Abstract: This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.Type: GrantFiled: June 5, 1995Date of Patent: September 22, 1998Assignee: The Regents of the University of CaliforniaInventors: Flossie Wong-Staal, Mang Yu, Osamu Yamada, Joshua O. Ojwang, Mark Leavitt, Anthony Ho
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Patent number: 5741706Abstract: GUC and GUA ribozymes which cleave HIV RNA are provided. The ribozymes cleave HIV RNA in vitro and in vivo. When the ribozymes are expressed in cells, they inhibit HIV replication in the cells.Type: GrantFiled: September 25, 1996Date of Patent: April 21, 1998Assignee: Immusol, IncorporatedInventors: Markley C. Leavitt, Richard Tritz, Elizabeth Duarte, Jack Barber, Mang Yu
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Patent number: 5670361Abstract: This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.Type: GrantFiled: May 17, 1994Date of Patent: September 23, 1997Assignee: The Regents of the University of CaliforniaInventors: Flossie Wong-Staal, Mang Yu, Osamu Yamada, Joshua O. Ojwang, Markley C. Leavitt, Anthony Ho
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Patent number: 5646034Abstract: Methods, kits and compositions for increasing the titer of rAAV vectors are provided.Type: GrantFiled: June 7, 1995Date of Patent: July 8, 1997Inventors: Michael Mamounas, Flossie Wong-Staal, Mark Leavitt, Mang Yu