Patents by Inventor Mangesh GORAKHANATH KAMBLE

Mangesh GORAKHANATH KAMBLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of acitrecin
    Patent number: 9919993
    Abstract: The present invention provides a process for preparation of {(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethyl)phenyl-3,7-dimethyl-nona-2,4,6,8}tetraenoate, an acitretin intermediate of formula (VI) with trans isomer ?97%, comprising of reacting 3-formyl-crotonic acid butyl ester of formula (V), substantially free of impurities, with 5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-penta-2,4-diene-1-triphenyl phosphonium bromide of formula (IV) and isolating resultant compound of formula (VI), treating the filtrate with iodine for isomerization of the undesired cis intermediate and finally obtaining acitretin (I), with desired trans isomer ?97%.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: March 20, 2018
    Assignee: Emcure Pharmaceuticals Limited
    Inventors: Mukund Keshav Gurjar, Shashikant Gangaram Joshi, Sachin Arvind Badhe, Mangesh Gorakhanath Kamble, Samit Satish Mehta
  • PROCESS FOR PREPARATION OF ACITRECIN
    Publication number: 20170275229
    Abstract: The present invention provides a process for preparation of {(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethyl)phenyl-3,7-dimethyl-nona-2,4,6,8}tetraenoate, an acitretin intermediate of formula (VI) with trans isomer?97%, comprising of reacting 3-formyl-crotonic acid butyl ester of formula (V), substantially free of impurities, with 5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-penta-2,4-diene-1-triphenyl phosphonium bromide of formula (IV) and isolating resultant compound of formula (VI), treating the filtrate with iodine for isomerization of the undesired cis intermediate and finally obtaining acitretin (I), with desired trans isomer?97%.
    Type: Application
    Filed: September 8, 2015
    Publication date: September 28, 2017
    Inventors: Gurjar Mukund KESHAV, Shashikant Gangaram JOSHI, Sachin Arvind BADHE, Mangesh GORAKHANATH KAMBLE, Samit Satish MEHTA
  • PROCESS FOR SYNTHESIS OF DIARYLPYRIMIDINE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR
    Publication number: 20110196156
    Abstract: A method for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor such as etravirine is provided Typically, etravirine is synthesized by the steps of a Condensing 2,4,6-trichlorpyrimidine with 3,5-dimethyl-4-hydroxybenzonitrile to obtain compound (V), b Condensing compound (V) with 4-aminobenzonitrile to obtain compound (VI), c Ammonolysis of compound (VI) to get compound (IV), d Halogenation of compound (IV) to get etravirine.
    Type: Application
    Filed: June 18, 2010
    Publication date: August 11, 2011
    Inventors: Mukund Keshav Gurjar, Golakchandra Sudarshan Maikap, Shashikant Gangaram Joshi, Devising Rameshing Pardeshi, Mangesh Gorakhanath Kamble, Samit Satish Mehta