Abstract: The present invention relates to a simple and convenient process for preparing solid lipid sustained release nanoparticles for berbamine delivery. The process involves preparation of nanoparticles by maintaining the pH of the aqueous or lipid phase so that high drug loading of 12-50% w/w with respect to the lipid matrix and high entrapment efficiency of more than 90% for berbamine in the solid lipid nanoparticles is achieved. The nanoformulation obtained by the process of the present invention has increased efficacy and exhibited any therapeutic property identical to free berbamine such as antiviral-cum-antibacterial agent for the treatment of microbial infections especially resistant Acinetobacter infections in treating diabetes and more specifically diabetes associated complications. Use may be extended to other diseases like COVID 19.

Abstract: The present invention relates to a process for extraction and freeze-drying of a Berberis extract. More particularly, the invention provides an optimized process for freeze-drying/lyophilization to increase the solubility of the extract into the surfactants for enhanced incorporation into a nano-carrier system. Furthermore, the present invention also relates to a lipid nano-formulation of freeze-dried Berberis extract and process for preparing the same by high-pressure homogenization. The invention also relates to the lipid nano-formulation of freeze-dried Berberis extract for efficient drug delivery, for dermatological and cosmeceutical purposes, for treating diabetes and diabetes associated complications, as a wound healer, as an antimicrobial, as an anti-infective, as an anti-inflammatory agent and as an antioxidant.

Abstract: Methods and systems for detecting a phishing attack on a computer device can involve scanning one or more email messages, and separating email parts from the one or more email messages, in response to scanning the at least one email message. In addition, the email parts of the at least one email message can be subject to a feature extraction operation. The email features extracted from the email parts can be then analyzed to determine whether or not any of the email features contain suspected phishing content, confirmed phishing content and benign email content.

Abstract: Methods and systems for detecting a phishing attack on a computer device can involve scanning one or more email messages, and separating email parts from the one or more email messages, in response to scanning the at least one email message. In addition, the email parts of the at least one email message can be subject to a feature extraction operation. The email features extracted from the email parts can be then analyzed to determine whether or not any of the email features contain suspected phishing content, confirmed phishing content and benign email content.

Abstract: A leak detector for detecting and locating leaks in a water supply pipe of plastics, the leak detector comprising a first sensor at a first position arranged to detect a leak signal travelling along a pipe, a second sensor arranged to detect a leak signal travelling along the pipe at a second position spaced from the first position, and a processing device adapted to receive the signals from the first sensor and the second sensor. The processing device may be adapted to determine the velocity of the signals from characteristics of the leak signals. The processing device is adapted to use the velocity and distance between the first sensor and the second sensor to determine the location of a leak. The characteristics may be the relationship between the phase and frequency of the leak signals.

Abstract: A leak detector for detecting and locating leaks in a water supply pipe of plastics, the leak detector comprising a first sensor at a first position arranged to detect a leak signal travelling along a pipe, a second sensor arranged to detect a leak signal travelling along the pipe at a second position spaced from the first position, and a processing device adapted to receive the signals from the first sensor and the second sensor. The processing device may be adapted to determine the velocity of the signals from characteristics of the leak signals. The processing device is adapted to use the velocity and distance between the first sensor and the second sensor to determine the location of a leak. The characteristics may be the relationship between the phase and frequency of the leak signals.