Patents by Inventor Maninder S. Hoba

Maninder S. Hoba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor
    Patent number: 7022672
    Abstract: A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: April 4, 2006
    Assignees: Chiron Corporation, G. D. Searle, LLC
    Inventors: Glenn J. Dorin, Bo H. Arve, Gregory L. Pattison, Robert F. Halenbeck, Kirk Johnson, Bao-Lu Chen, Rejsharan K. Bana, Maninder S. Hoba, Hassan Madani, Michael Tsang, Mark E. Gustafson, Gary S. Bild, Gary V. Johnson
  • Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor
    Publication number: 20020137884
    Abstract: A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.
    Type: Application
    Filed: November 30, 2001
    Publication date: September 26, 2002
    Applicant: Chiron Corporation
    Inventors: Glenn J. Dorin, Bo H. Arve, Gregory L. Pattison, Robert F. Halenback, Kirk Johnson, Bao-Lu Chen, Rajsharan K. Bana, Maninder S. Hoba, Hassan Madani, Michael Tsang, Mark E. Gustafson, Gary S. Bild, Gary V. Johnson
  • Method of solubilizing, purifying, and refolding protein
    Patent number: 6323326
    Abstract: A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: November 27, 2001
    Assignees: Chiron Corporation, G. D. Searle & Co.
    Inventors: Glenn J. Dorin, Bo H. Arve, Gregory L. Pattison, Robert F Halenbeck, Kirk Johnson, Bao-Lu Chen, Rajsharan K. Rana, Maninder S. Hoba, Hassan Madani, Michael Tsang, Mark E. Gustafson, Gary S. Bild, Gary V. Johnson