Abstract: A microfluidic device and a method for sensing and sorting of cells or particles in a microfluidic channel are disclosed. The microfluidic device may include a substrate with a microfluidic channel having an inlet, the microfluidic channel being coupled with two or more output channels; one or more sensors located adjacent to a first region of the microfluidic channel for sensing respective particles flown through the microfluidic channel; and a first piezoelectric actuator located adjacent to a second region of the microfluidic channel downstream from the first region for deflecting the respective particles flowing through the microfluidic channel to respective output channels of the two or more output channels based on signals from the one or more sensors.

Abstract: A microfluidic device and a method for manipulating, and sensing at least one property of, cells or particles in a microfluidic channel are disclosed. The microfluidic device includes a microfluidic channel arranged on a substrate, a sensing zone arranged along a portion of the microfluidic channel, and a set of piezoelectric actuators arranged in proximity to the sensing zone. The sensing zone is configured to measure one or more properties of a cell or a particle in a fluid sample in the microfluidic channel. The set of piezoelectric actuators is configured to cause manipulation of the particle while the particle is in the sensing zone.

Abstract: A microfluidic device and a method for dissociating and manipulating cells or particles in a microfluidic channel are disclosed. The microfluidic device includes an inlet, an outlet, and a microfluidic channel arranged on a substrate between the inlet and the outlet. The microfluidic device includes a first set of piezoelectric actuators arranged adjacent to the inlet channel and configured to dissociate particles of a fluidic sample in the microfluidic channel. The microfluidic device includes a second set of piezoelectric actuators arranged between the inlet channel and the outlet channel and configured to manipulate the particles of the fluidic sample as the particles move through the microfluidic channel. The microfluidic device includes a third set of piezoelectric actuators arranged above the outlet channel, adjacent to the outlet, and configured to eject a portion of the fluidic sample out of the microfluidic channel via the outlet.

Abstract: A microfluidic device and a method for flow control of cells or particles in a microfluidic channel are disclosed. The microfluidic device may include a substrate having an outlet channel. The microfluidic device may also include a microfluidic channel arranged on the substrate such that an outlet of the microfluidic channel is positioned above the outlet channel. The microfluidic device may further include a set of piezoelectric actuators arranged above the outlet channel and adjacent to the outlet, the set of piezoelectric actuators configured to eject a portion of a fluid out of the microfluidic channel via the outlet.

Abstract: A digital dispense system and methods for preparing samples for analysis. The digital dispense system includes a fluid droplet ejection system housed in a housing unit. The fluid droplet ejection system contains a fluid droplet ejection head and fluid cartridge containing one or more fluids to be dispensed. A cartridge translation mechanism is provided for moving the fluid droplet ejection head and fluid cartridge back and forth over a sample holder in an x direction. A sample tray translation mechanism moves a sample tray back and forth beneath the fluid droplet ejection head and fluid cartridge in a y direction orthogonal to the x direction.

Abstract: A microfluidic device and a method for flow control of cells or particles in a microfluidic channel are disclosed. The microfluidic device may include a substrate with a microfluidic channel having at least one outlet; a first array of piezoelectric actuators located adjacent to the outlet for ejecting a portion of a fluid in the microfluidic channel; and one or more pairs of electrodes for charging particles (in the fluid) flowing through the microfluidic channel so that the particles can be manipulated with an electrical field.

Abstract: A microfluidic device and a method for flow control of cells or particles in a microfluidic channel are disclosed. The microfluidic device may include a substrate with a microfluidic channel having at least one outlet; a first array of piezoelectric actuators located adjacent to the outlet for ejecting a portion of a fluid in the microfluidic channel; and one or more pairs of electrodes for charging particles (in the fluid) flowing through the microfluidic channel so that the particles can be manipulated with an electrical field.

Abstract: A microfluidic device and a method for sensing and sorting of cells or particles in a microfluidic channel are disclosed. The microfluidic device may include a substrate with a microfluidic channel having an inlet, the microfluidic channel being coupled with two or more output channels; one or more sensors located adjacent to a first region of the microfluidic channel for sensing respective particles flown through the microfluidic channel; and a first piezoelectric actuator located adjacent to a second region of the microfluidic channel downstream from the first region for deflecting the respective particles flowing through the microfluidic channel to respective output channels of the two or more output channels based on signals from the one or more sensors.

Abstract: Various embodiments described herein include methods and devices for the evaluation of sub-cellular and molecular structures of cells and particles. In one aspect, a microfluidic device includes: (i) a sensor positioned adjacent to a microfluidic channel for detecting particles flowing through the microfluidic channel and (ii) a transmission line positioned adjacent to the sensor for receiving electromagnetic signals from the sensor.

Abstract: Examples herein provide a device. The device includes a sample delivery component, which includes: a reagent chamber to contain at least one reagent; a sample chamber to contain a fluid sample; and a delivery channel extending from the reagent chamber and in fluid communication with the sample chamber and an output port, wherein the delivery channel is conducive mixing the at least one reagent and the fluid sample to form a mixture before the mixture reaches the output port and be discharged therefrom. The device includes a testing cassette detachable from the delivery component, which includes: an input port in fluid communication with a microfluidic reservoir, the input port to receive the discharged fluid sample from the output port; and a micro-fabricated integrated sensor in a microfluidic channel extending from the microfluidic reservoir.

Abstract: A digital dispense system and methods for preparing samples for analysis. The digital dispense system includes a fluid droplet ejection system housed in a housing unit. The fluid droplet ejection system contains a fluid droplet ejection head and fluid cartridge containing one or more fluids to be dispensed. A cartridge translation mechanism is provided for moving the fluid droplet ejection head and fluid cartridge back and forth over a sample holder in an x direction. A sample tray translation mechanism moves a sample tray back and forth beneath the fluid droplet ejection head and fluid cartridge in a y direction orthogonal to the x direction.

Abstract: A diagnostic cassette includes a substrate, to physically and electrically connect the product to a computing device, a reservoir defined within the substrate to receive a fluid sample for processing by the diagnostic cassette, a reagent to react with the fluid sample deposited in the reservoir to form a solution to enable processing of the fluid sample by the diagnostic cassette, a channel to direct the solution, and a sensor to measure a number of parameters of the solution passing through the channel. A method for measuring microfluidic samples includes receiving, in a reservoir, a fluid sample to be measured, combining the fluid sample with a reagent to create a solution, moving the solution through a channel, and measuring the solution, using sensors, as the solution passes through the channel.

Abstract: A digital dispense system and methods for preparing samples for analysis. The digital dispense system includes a fluid droplet ejection system housed in a housing unit. The fluid droplet ejection system contains a fluid droplet ejection head and fluid cartridge containing one or more fluids to be dispensed. A cartridge translation mechanism is provided for moving the fluid droplet ejection head and fluid cartridge back and forth over a sample holder in an x direction. A sample tray translation mechanism moves a sample tray back and forth beneath the fluid droplet ejection head and fluid cartridge in a y direction orthogonal to the x direction.

Abstract: A pharmaceutical drug delivery device and method of using the pharmaceutical drug delivery device. The pharmaceutical drug delivery device includes a cartridge body; a fluid outlet nozzle attached to the cartridge body; and a fluid jet ejection cartridge disposed in the cartridge body, wherein the cartridge contains a liquid pharmaceutical drug and a fluid ejection head containing a plurality of fluid ejection nozzles and associated fluid ejectors. A processor disposed on a logic board or fluid ejection head is provided for executing a control algorithm to control the ejection head to modify plume characteristics of fluid ejected from the ejection head by controlling one or more of fluid jet firing frequency, burst length, and fluid jet firing burst delay.

Abstract: A system may comprise a voltage upconverter, a universal serial bus (USB) connector to receive an input voltage from a USB port on a computing device, and a microfluidic diagnostic chip communication link to electrically couple the voltage upconverter to a microfluidic diagnostic chip wherein the voltage upconverter is to convert the input voltage to be received by the USB connector to an output voltage sufficient to drive a pump on the microfluidic diagnostic chip. A diagnostic system may comprise a microfluidic diagnostic chip comprising a pump and a voltage upconverter to receive an input voltage from a universal serial bus (USB) port of a computing device and to convert the input voltage into an output voltage that powers activation of the pump.

Abstract: A device including a microfluidic channel structure formed on a substrate and including a first channel and a fluid actuator within the microfluidic channel structure. A sense region within the first channel is to receive a fluid flow of target biologic particles for counting in a single file pattern, with the sense region having a volume on a same order of magnitude as a volume of a single one of the target biologic particles.

Abstract: According to an example, a microfluidic apparatus may include a channel, a foyer, in which the foyer is in fluid communication with the channel and in which the channel has a smaller width than the foyer, a sensor to sense a property of a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to determine whether the sensed property of the fluid meets a predetermined condition and to perform a predefined action in response to the sensed property of the fluid meeting the predetermined condition.

Abstract: The present disclosure is drawn to microfluidic chips. The microfluidic chips can include an inflexible material having an elastic modulus of 0.1 gigapascals (GPa) to 450 GPa. A microfluidic channel can be formed within the inflexible material and can connect an inlet and an outlet. A working electrode can be associated with the microfluidic channel and can have a surface area of 1 ?m2 to 60,000 ?m2 within the microfluidic channel. A bubble support structure can also be formed within the microfluidic channel such that the working electrode is positioned to electrolytically generate a bubble that becomes associated with the bubble support structure.

Abstract: Examples herein provide a method. The method includes applying an electrical potential difference over a blood sample in a testing cassette of a microfluidic device, the cassette including a microfluidic channel through which the blood sample flows. The method includes measuring, over a duration of time, an electrical signal passing through the blood sample as the blood sample flows from a first end and coagulates at a second end of the microfluidic channel to obtain a measurement function as a function of time. The method also includes correlating the measurement function to a characteristic of the blood sample.

Abstract: A device includes a microfluidic channel structure on a substrate with a first fluid actuator and a second fluid actuator within the microfluidic channel structure. One of the fluid actuators is selectively employable to at least partially reverse fluid flow within at least a portion of the microfluidic channel structure in response to a blockage or to prevent a blockage.