Patents by Inventor Manish Kumar Aneja
Manish Kumar Aneja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11981910Abstract: Described are DNA molecules which can be transcribed into an mRNA harbouring novel UTR sequences combining the advantages of being extremely short and at the same time allowing for high translation efficiencies of RNA molecules containing them. Further, described are vectors comprising such a DNA molecule and to host cells comprising such a vector. Moreover, described are corresponding RNA molecules containing such UTRs. Further, described is a pharmaceutical composition comprising the described RNA molecule and optionally a pharmaceutically acceptable carrier as well as to the use of the described UTRs for translating a coding region of an RNA molecule into a polypeptide or a protein encoded by said coding region.Type: GrantFiled: June 6, 2022Date of Patent: May 14, 2024Assignee: ethris GmbHInventors: Christian Plank, Carsten Rudolph, Manish Kumar Aneja, Ludwig Weiss
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Publication number: 20230086606Abstract: Described are DNA molecules which can be transcribed into an mRNA harbouring novel UTR sequences combining the advantages of being extremely short and at the same time allowing for high translation efficiencies of RNA molecules containing them. Further, described are vectors comprising such a DNA molecule and to host cells comprising such a vector. Moreover, described are corresponding RNA molecules containing such UTRs. Further, described is a pharmaceutical composition comprising the described RNA molecule and optionally a pharmaceutically acceptable carrier as well as to the use of the described UTRs for translating a coding region of an RNA molecule into a polypeptide or a protein encoded by said coding region.Type: ApplicationFiled: June 6, 2022Publication date: March 23, 2023Inventors: Christian Plank, Carsten Rudolph, Manish Kumar Aneja, Ludwig Weiss
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Patent number: 11479768Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with a gene of the ATP-binding cassette (ABC) family, such as ABCA3.Type: GrantFiled: June 30, 2016Date of Patent: October 25, 2022Assignee: Ethris GmbHInventors: Christian Plank, Carsten Rudolph, Manish Kumar Aneja, Ludwig Weiss, Mehrije Ferizi, Johannes Geiger
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Patent number: 11352638Abstract: Described are DNA molecules which can be transcribed into an mRNA harbouring novel UTR sequences combining the advantages of being extremely short and at the same time allowing for high translation efficiencies of RNA molecules containing them. Further, described are vectors comprising such a DNA molecule and to host cells comprising such a vector. Moreover, described are corresponding RNA molecules containing such UTRs. Further, described in a pharmaceutical composition comprising the described RNA molecule are optionally a pharmaceutically acceptable carrier as well as to the use of the described UTRs for translating a coding region of an RNA molecule into a polypeptide or a protein encoded by said coding region.Type: GrantFiled: March 30, 2017Date of Patent: June 7, 2022Assignee: ethris GmbHInventors: Christian Plank, Carsten Rudolph, Manish Kumar Aneja, Ludwig Weiss
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Publication number: 20210348172Abstract: The present disclosure provides a DNA plasmid comprising a sequence which encodes an mRNA molecule and a modified poly(A) tail, wherein the part of the sequence that encodes the modified poly(A) tail is characterized in that it consists of at least two A elements each defined as a nucleotide sequence consisting of 55 to 65 T nucleotides and at least one S element each S element consisting of one nucleotide that is not a T nucleotide, or 2 to 10 nucleotides, preferably 6 nucleotides, wherein each of the two terminal nucleotides is not a T nucleotide, wherein the number of A elements is one more than the number of S elements, and wherein any two A elements are separated by one S element; said DNA plasmid exhibiting a reduced recombination during amplification in a bacterial host cell compared to the same DNA plasmid without said at least one S element.Type: ApplicationFiled: October 10, 2019Publication date: November 11, 2021Inventors: Zeljka TREPOTEC, Manish Kumar ANEJA, Carsten RUDOLPH, Christian PLANK, Ludwig WEISS
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Patent number: 11136585Abstract: Described is an RNA molecule comprising (a) a coding region coding for a polypeptide; and (b) upstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:1 or a sequence which shows 1 to 4 substitutions in comparison to SEQ ID NO:1 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:1; and/or (c) downstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:2 or a sequence which shows 1 to 7 substitutions in comparison to SEQ ID NO:2 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:2; wherein said polypeptide encoded by said coding region is not a cytochrome b-245 alpha polypeptide (CYBA). Moreover, described is a nucleic acid molecule encoding the RNA molecule according to the present invention.Type: GrantFiled: June 30, 2016Date of Patent: October 5, 2021Assignee: ethris GmbHInventors: Carsten Rudolph, Manish Kumar Aneja, Mehrije Ferizi, Johannes Geiger
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Patent number: 11104887Abstract: In certain aspects, the disclosure relates to compositions comprising modified Ornithine transcarbamylase (OTC) polyribonucleotides and methods of use.Type: GrantFiled: December 15, 2017Date of Patent: August 31, 2021Assignee: ethris GmbHInventors: Carsten Rudolph, Rebekka Kubisch-Dohmen, Manish Kumar Aneja, Johannes Geiger, Marino Schuhmacher
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Patent number: 10927383Abstract: In certain aspects, the disclosure relates to compositions comprising modified Cas9 polyribonucleotides and methods of use, as well as Cas9 polynucleotides and polyribonucleotides.Type: GrantFiled: June 30, 2017Date of Patent: February 23, 2021Assignee: ethris GmbHInventors: Manish Kumar Aneja, Rebekka Kubisch-Dohmen, Christian Plank, Carsten Rudolph
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Publication number: 20200308556Abstract: In certain aspects, the disclosure relates to compositions comprising modified Ornithine transcarbamylase (OTC) polyribonucleotides and methods of use.Type: ApplicationFiled: December 15, 2017Publication date: October 1, 2020Inventors: Carsten Rudolph, Rebekka Kubisch-Dohem, Manish Kumar Aneja, Johannes Geiger, Marino Schuhmacher
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Publication number: 20190194669Abstract: Described is an RNA molecule comprising (a) a coding region coding for a polypeptide; and (b) upstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:1 or a sequence which shows 1 to 4 substitutions in comparison to SEQ ID NO:1 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:1; and/or (c) downstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:2 or a sequence which shows 1 to 7 substitutions in comparison to SEQ ID NO:2 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:2; wherein said polypeptide encoded by said coding region is not a cytochrome b-245 alpha polypeptide (CYBA). Moreover, described is a nucleic acid molecule encoding the RNA molecule according to the present invention.Type: ApplicationFiled: June 30, 2016Publication date: June 27, 2019Applicant: Ethris GmbHInventors: Carsten Rudolph, Manish Kumar Aneja, Mehrije Ferizi, Johannes Geiger
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Publication number: 20190144883Abstract: Described are DNA molecules which can be transcribed into an mRNA harbouring novel UTR sequences combining the advantages of being extremely short and at the same time allowing for high translation efficiencies of RNA molecules containing them. Further, described are vectors comprising such a DNA molecule and to host cells comprising such a vector. Moreover, described are corresponding RNA molecules containing such UTRs. Further, described in a pharmaceutical composition comprising the described RNA molecule are optionally a pharmaceutically acceptable carrier as well as to the use of the described UTRs for translating a coding region of an RNA molecule into a polypeptide or a protein encoded by said coding region.Type: ApplicationFiled: March 30, 2017Publication date: May 16, 2019Inventors: Christian Plank, Carsten Rudolph, Manish Kumar Aneja, Ludwig Weiss
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Publication number: 20180371456Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with a gene of the ATP-binding cassette (ABC) family, such as ABCA3.Type: ApplicationFiled: June 30, 2016Publication date: December 27, 2018Applicant: Ethris GmbHInventors: Christian PLANK, Carsten RUDOLPH, Manish Kumar ANEJA, Ludwig WEISS, Mehrije FERIZI, Johannes GEIGER
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Publication number: 20180163213Abstract: In certain aspects, the disclosure relates to compositions comprising modified Cas9 polyribonucleotides and methods of use, as well as Cas9 polynucleotides and polyribonucleotides.Type: ApplicationFiled: June 30, 2017Publication date: June 14, 2018Inventors: Manish Kumar Aneja, Rebekka Kubisch-Dohmen, Christian Plank, Carsten Rudolph
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Publication number: 20150126589Abstract: The invention discloses a method for expressing an mRNA in lung wherein —the mRNA to be expressed is combined with polyethyleneimine (PEI) to provide a combination comprising the mRNA and PEI; —the combination comprising the mRNA and PEI is administered to lung where it enters lung cells; and —the mRNA is expressed in the lung cells.Type: ApplicationFiled: June 7, 2013Publication date: May 7, 2015Inventors: Johannes Geiger, Manish Kumar Aneja, Carsten Rudolph