Patents by Inventor Manish Popatial Patel

Manish Popatial Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE MANUFACTURE OF MONTELUKAST SODIUM
    Publication number: 20090182148
    Abstract: An improved process for the manufacture of 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropane acetic acid, sodium salt [montelukast sodium(I)]. It consists of converting a vital intermediate 1-(mercaptomethyl)-cyclopropane acetic acid of formula IX, to a quaternary ammonium salt of formula X, using a suitable base in a suitable solvent at 0° C. to 50° C. followed by monometalation to provide an intermediate of formula XI and subsequent condensation of XI with 2-[2-[3-(S)-[3-[2-(7-chloro-2-quinolinyl)-ethenyl]phenyl]-3-methanesulphonyloxypropyl]phenyl]-2-propanol at 0 to ?50° C.
    Type: Application
    Filed: January 16, 2006
    Publication date: July 16, 2009
    Inventors: Harmander Singh Pal Chawla, Anil Shankar Chowdhary, Ajay Mangubhai Patel, Vipul Narbheshankar Joshi, Manish Popatial Patel