Patents by Inventor Manish Tandon

Manish Tandon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS
    Publication number: 20100249108
    Abstract: The present invention relates to substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
    Type: Application
    Filed: March 31, 2010
    Publication date: September 30, 2010
    Applicant: ArQule, Inc.
    Inventors: Manish Tandon, Yanbin Liu, Nivedita Namdev, Mark A. Ashwell, Rocio Palma
  • SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS
    Publication number: 20100249120
    Abstract: The present invention relates to substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
    Type: Application
    Filed: March 31, 2010
    Publication date: September 30, 2010
    Applicant: ArQule, Inc.
    Inventors: Jason Hill, Manish Tandon, Nivedita Namdev, Rocio Palma, Neil Westlund, Anton Filikov
  • SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS
    Publication number: 20100249127
    Abstract: The present invention relates to substituted indolo-pyridinone compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted indolo-pyridinone compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
    Type: Application
    Filed: March 31, 2010
    Publication date: September 30, 2010
    Applicant: ArQule, Inc.
    Inventors: Nivedita Namdev, Manish Tandon, Jianqiang Wang, Audra Dalton, David Vensel, Rocio Palma, Mark A. Ashwell, Neil Westlund
  • SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS
    Publication number: 20100249110
    Abstract: The present invention relates to substituted pyrazolo-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrazolo-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
    Type: Application
    Filed: March 31, 2010
    Publication date: September 30, 2010
    Applicant: ArQule, Inc.
    Inventors: Manish Tandon, Jianqiang Wang, Nivedita Namdev
  • SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS
    Publication number: 20100239525
    Abstract: The present invention relates to substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
    Type: Application
    Filed: December 30, 2009
    Publication date: September 23, 2010
    Applicant: ArQule, Inc.
    Inventors: Syed M. Ali, Mark A. Ashwell, Sudharshan Eathiraj, Eugene Kelleher, Jean-Marc Lapierre, Yanbin Liu, Nivedita Namdev, Rocio Palma, Manish Tandon, David Vensel, Neil Westlund, Hui Wu, Rui-Yang Yang
  • SUBSTITUTED IMIDAZOLYL-5,6-DIHYDROBENZO[N]ISOQUINOLINE COMPOUNDS
    Publication number: 20100239526
    Abstract: The present invention relates to substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
    Type: Application
    Filed: December 30, 2009
    Publication date: September 23, 2010
    Applicant: ArQule, Inc.
    Inventors: Syed M. Ali, Mark Ashwell, Chris Brassard, Audra Dalton, Anton Filikov, Jason Hill, Nivedita Namdev, Rocio Palma, Manish Tandon, David Vensel, Jianqiang Wang, Neil Westlund
  • Hydroxy sulfonate of quinone compounds and their uses
    Patent number: 7790765
    Abstract: The present invention provides sodium 6-hydroxy-2,2-dimethyl-5-oxo-3,4,5,6-tetrahydro-2H-benzo(h)chromene-6-sulfonate, and its synthesis and uses in the treatment of cancer.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: September 7, 2010
    Assignee: ArQule, Inc.
    Inventors: Judit Bartis, Erika Volckova, Manish Tandon, Deirdre Lowe, Martin P. Redmon
  • RAF Inhibitors and Their Uses
    Publication number: 20100183600
    Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their syntheses. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.
    Type: Application
    Filed: December 4, 2009
    Publication date: July 22, 2010
    Applicant: ARQULE, INC.
    Inventors: Jean-Marc Lapierre, Yanbin Liu, Manish Tandon, Mark A. Ashwell
  • SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS
    Publication number: 20100172867
    Abstract: The present invention relates to substituted 1H-pyrazolo-[3,4-d]pyrimidine-6-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 1H-pyrazolo-[3,4-d]pyrimidine-6-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
    Type: Application
    Filed: December 30, 2009
    Publication date: July 8, 2010
    Applicant: ArQule, Inc.
    Inventors: Syed M. Ali, Mark A. Ashwell, Jason Hill, Jean-Marc Lapierre, Magdi Moussa, Nivedita Namdev, Robert Nicewonger, Manish Tandon, Rui-Yang Yang
  • Pharmaceutical compositions of beta-lapachone and beta-lapachone analogs with improved tumor targeting potential
    Publication number: 20090226395
    Abstract: The present invention relates to polymer-modified quinone-containing and carbonyl-containing therapeutic agents, including polymer-modified ?-lapachone compounds, and methods of treating cancer by administering the polymer-modified therapeutic agents to a subject. Polymer-modification of therapeutic agents, such as ?-lapachone compounds, provides effective transport of polymer-modified therapeutic agents to tumor cells or tumor tissues by exploiting the EPR effect in tumor tissues.
    Type: Application
    Filed: May 1, 2009
    Publication date: September 10, 2009
    Applicant: ArQule, Inc.
    Inventors: Mark A. Ashwell, Chiang J. Li, Manish Tandon, Yanbin Liu, Jean-Marc LaPierre, Zhiwei Jiang
  • NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20090176801
    Abstract: The invention provides lapachone analogs and derivatives as well as methods of use thereof. These compounds can be used in pharmaceutical compositions for the treatment or prevention of cell proliferation disorders. These compounds can also be used in the treatment or prevention of cancer or precancerous conditions.
    Type: Application
    Filed: October 16, 2008
    Publication date: July 9, 2009
    Applicant: ArQule, Inc.
    Inventors: Mark Ashwell, Manish Tandon, Jean-Marc Lapierre, Syed Ali, Yanbin Liu, Chiang J. Li
  • RAF Inhibitors and Uses Thereof
    Publication number: 20090136499
    Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.
    Type: Application
    Filed: January 20, 2009
    Publication date: May 28, 2009
    Applicant: ARQULE, INC.
    Inventors: Jean-Marc Lapierre, Nivedita D. Namdev, Mark A. Ashwell, Dennis S. France, Hui Wu, Patrick M. Hutchins, Manish Tandon, Yanbin Liu, Jeff S. Link, Syed M. Ali, Chris J. Brassard, Robb B. Nicewonger, Anton Filikov, Rebecca J. Carazza
  • Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
    Publication number: 20090111985
    Abstract: An efficient route for the synthesis is of formula (I) of imidazooxazole and imidazothiazole inhibitors of the p38 MAP kinase pathway, useful as therapeutics for disease conditions including inflammation and auto-immune responses is described.
    Type: Application
    Filed: October 19, 2005
    Publication date: April 30, 2009
    Inventors: Mark A. Ashwell, Manish Tandon, Jean-Marc Lapierre
  • Novel lapachone compounds and methods of use thereof
    Publication number: 20090105166
    Abstract: The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as ?-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione).
    Type: Application
    Filed: August 21, 2007
    Publication date: April 23, 2009
    Inventors: Mark A. Ashwell, Manish Tandon, Jean-Marc Lapierre, Syed Ali, David Vensel, Chiang J. Li
  • RAF inhibitors and their uses
    Patent number: 7501430
    Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.
    Type: Grant
    Filed: April 16, 2007
    Date of Patent: March 10, 2009
    Assignee: ArQule, Inc.
    Inventors: Jean-Marc Lapierre, Nivedita D. Namdev, Mark A. Ashwell, Dennis S. France, Hui Wu, Patrick M. Hutchins, Manish Tandon, Yanbin Liu, Jeff S. Link, Syed M. Ali, Chris J. Brassard, Robb B. Nicewonger, Anton Filikov, Rebecca J. Carazza
  • Hydroxy sulfonate of quinone compounds and their uses
    Publication number: 20090028952
    Abstract: The present invention provides sodium 6-hydroxy-2,2-dimethyl-5-oxo-3,4,5,6-tetrahydro-2H-benzo(h)chromene-6-sulfonate, and its synthesis and uses in the treatment of cancer.
    Type: Application
    Filed: April 30, 2008
    Publication date: January 29, 2009
    Inventors: Judit Bartis, Erika Volckova, Manish Tandon, Deirdre Lowe, Martin P. Redmon
  • RAF inhibitors and their uses
    Publication number: 20070281955
    Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.
    Type: Application
    Filed: April 16, 2007
    Publication date: December 6, 2007
    Inventors: Jean-Marc Lapierre, Nivedita Namdev, Mark Ashwell, Dennis France, Hui Wu, Patrick Hutchins, Manish Tandon, Yanbin Liu, Jeff Link, Syed Ali, Chris Brassard, Robb Nicewonger, Anton Filikov, Rebecca Carazza
  • Inhibitors of P38 and Methods of Using the Same
    Publication number: 20070270418
    Abstract: In general, the present invention relates to compounds capable of inhibiting p38, methods for inhibiting p38 in vivo or in vitro, and methods for treating conditions associated with p38 activity or cytokine activity.
    Type: Application
    Filed: May 14, 2004
    Publication date: November 22, 2007
    Inventors: Mark Ashwell, Syed Ali, Jifeng Liu, Yanbin liu, Peter Lohse, Belew Mekonnen, Robert Selliah, Manish Tandon, Woj Wrona, Valery Antonenko
  • Pharmaceutical compositions of beta-lapachone and beta-lapachone analogs with improved tumor targeting potential
    Publication number: 20060034796
    Abstract: The present invention relates to polymer-modified quinone-containing and carbonyl-containing therapeutic agents, including polymer-modified ?-lapachone compounds, and methods of treating cancer by administering the polymer-modified therapeutic agents to a subject. Polymer-modification of therapeutic agents, such as ?-lapachone compounds, provides effective transport of polymer-modified therapeutic agents to tumor cells or tumor tissues by exploiting the EPR effect in tumor tissues.
    Type: Application
    Filed: August 11, 2005
    Publication date: February 16, 2006
    Inventors: Mark Ashwell, Chiang Li, Manish Tandon, Yanbin Liu, Jean-Marc LaPierre, Zhiwei Jiang
  • Quinone prodrug compositions and methods of use
    Publication number: 20060035963
    Abstract: The present invention relates to quinone prodrug compositions and therapeutic methods using such prodrug compositions. Preferably, the quinone compounds of the invention are napthoquinone compounds such as ?-lapachone or ?-lapachone analogs. The quinone prodrug compositions of the invention exhibit improved solubility, stability, bioavailability, and pharmacokinetic properties, as well as improved plasma half-life in vivo.
    Type: Application
    Filed: August 11, 2005
    Publication date: February 16, 2006
    Inventors: Mark Ashwell, Manish Tandon, Jean-Marc Lapierre, Yanbin Liu