Patents by Inventor Manjinder Singh Phull

Manjinder Singh Phull has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10300044
    Abstract: Amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate free base, amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate dihydrochloride, methods of making them, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: May 28, 2019
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Manjinder Singh Phull, Shashirekha Kanathala, Manish Gopaldas Gangrade
  • Publication number: 20180235944
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Application
    Filed: January 17, 2018
    Publication date: August 23, 2018
    Applicant: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Muruti Ghagare
  • Patent number: 9877953
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: January 30, 2018
    Assignee: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Maruti Ghagare
  • Publication number: 20170354644
    Abstract: Amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate free base, amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate dihydrochloride, methods of making them, and pharmaceutical compositions containing them.
    Type: Application
    Filed: December 24, 2015
    Publication date: December 14, 2017
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Manjinder Singh PHULL, Shashirekha KANATHALA, Manish Gopaldas GANGRADE
  • Publication number: 20160374999
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Application
    Filed: July 29, 2016
    Publication date: December 29, 2016
    Applicant: CIPLA Limited
    Inventors: Dharmaraj R. Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Maruti Ghagare
  • Patent number: 9403844
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: August 2, 2016
    Assignee: Cipla Ltd.
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Maruti Ghagare
  • Patent number: 9227990
    Abstract: The present invention provides a compound of the Formula (I) wherein R is 9-isopropyl-9H-purin-6-amine; 2-amino-9-isopropyl-1H-purin-6(9H)-one; 4-amino-1-isopropyl pyrimidin-2(1H)-one; or 1-isopropyl-5-methylpyrimidine-2,4(1H,3H)-dione, R? is —CH2OC(O)R?, and R? is —C(CH3)3 or —CH(CH3)2 including pharmaceutically acceptable salts thereof. The present invention also provides a process for preparing a compound of formula (Ia) and a compound of formula (I) for use in treating a viral infection.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: January 5, 2016
    Assignee: CIPLA LIMITED
    Inventors: Manjinder Singh Phull, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao
  • Publication number: 20150291639
    Abstract: The present invention provides a compound of the Formula (I) wherein R is 9-isopropyl-9H-purin-6-amine; 2-amino-9-isopropyl-1H-purin-6(9H)-one; 4-amino-1-isopropyl pyrimidin-2(1H)-one; or 1-isopropyl-5-methylpyrimidine-2,4(1H,3H)-dione, R? is —CH2OC(O)R?, and R? is —C(CH3)3 or —CH(CH3)2 including pharmaceutically acceptable salts thereof. The present invention also provides a process for preparing a compound of formula (Ia) and a compound of formula (I) for use in treating a viral infection.
    Type: Application
    Filed: October 29, 2013
    Publication date: October 15, 2015
    Applicant: Cipla Limited
    Inventors: Manjinder Singh Phull, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao
  • Publication number: 20150266898
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Application
    Filed: June 8, 2015
    Publication date: September 24, 2015
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull
  • Publication number: 20150141383
    Abstract: There is disclosed crystalline darunavir hydrate substantially free of any non-aqueous solvent.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 21, 2015
    Inventors: Manjinder Singh PHULL, Dharmaraj Ramachandra RAO, Rajendra Narayanrao KANKAN
  • Patent number: 9000158
    Abstract: In an embodiment, the present invention provides a process for preparing (?)-6-(4-aminophenyl)-5-methylpyridazin-3-(2H)-one, which process comprises: a) reacting racemic 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone of formula II with a chiral tartaric acid derivative to obtain a diastereomeric salt of (?)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone and the chiral tartaric acid derivative; and b) reacting the diastereomeric salt with a base to obtain (?)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone. The (?)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone may be used to prepare levosimendan.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: April 7, 2015
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Ashwini Amol Sawant
  • Patent number: 8993789
    Abstract: The present invention provides a process for preparing methyl 5-acetamido-4-amino-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (V), which process comprises reducing methyl 5-acetamido-4-azido-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (IV) in the presence of a reducing agent selected from the group consisting of lithium aluminum hydride, sodium borohydride, zinc/ammonium chloride, zinc-ferric chloride and ferric chloride/sodium iodide. The present invention also provides compounds of formula (VIII) and (IX) which may be used in the synthesis of zanamivir. The present invention also provides processes for preparing compounds (VIII) and (IX) and processes involving their use, including in the synthesis of zanamivir.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: March 31, 2015
    Assignee: Cipla Limited
    Inventors: Manjinder Singh Phull, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Ashwini Amol Sawant, Sanoj Thoppil
  • Publication number: 20140128419
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Application
    Filed: January 10, 2014
    Publication date: May 8, 2014
    Applicant: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull
  • Patent number: 8658821
    Abstract: A one-pot process for the preparation of nateglinide, which process comprises reacting an alkyl ester of D-phenylalanine of formula (II): where R represents C1-4alkyl, typically methyl, either as the free base or in salt form (typically the hydrochloride), with trans-4-isopropylcyclohexanecarboxylic acid of formula (III): where X represents hydroxy or halo, typically chloro, to obtain a C1-4 alkyl ester of nateglinide of formula (IV), preferably the methyl ester of nateglinide: followed by hydrolysis to yield nateglinide of formula (I):
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: February 25, 2014
    Assignee: Cipla Limited
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Manjinder Singh Phull, Dilip Ramdas Birari
  • Patent number: 8633234
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: January 21, 2014
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Maruti Ghagare
  • Patent number: 8519126
    Abstract: Crystalline Form C of tenofovir disoproxil, salts thereof and a process for its preparation. The process involves adding a solution comprising tenofovir disoproxil and an organic solvent to salt-saturated water, whereby the crystalline Form C of tenofovir disoproxil precipitates. The crystalline Form C of tenofovir disoproxil may be converted to a salt thereof. There is also provided a process for purifying a crude product comprising tenofovir monoisoproxil and tenofovir disoproxil.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: August 27, 2013
    Assignee: Cipla Limited
    Inventors: Manjinder Singh Phull, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao
  • Patent number: 8481730
    Abstract: The present invention relates to alkaline earth metal salts of bosentan, anyhdrous bosentan, polymorphic forms thereof, amorphous bosentan and processes for preparing them. The present invention further relates to a process for the preparation of bosentan and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: January 2, 2009
    Date of Patent: July 9, 2013
    Assignee: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Ashwini Amol Sawant
  • Patent number: 8461388
    Abstract: A process for preparing a compound of formula (V) or its enantiomer, which comprises: (a) reacting racemic aminoindan of formula (II) or its enantiomer with allylhalide in presence of a base and an organic solvent at a temperature ranging from 25 C to the reflux temperature of the solvent to give compound of formula (III); Where R is H or (b) reacting the compound (III) with halogenating agent in a suitable organic solvent to give a dihalo compound of formula (IV). (c) treating the dihalo compound (IV) with a suitable base to give compound (V).
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: June 11, 2013
    Assignee: CIPLA Limited
    Inventors: Manjinder Singh Phull, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Publication number: 20130029945
    Abstract: There is disclosed crystalline darunavir hydrate substantially free of any non-aqueous solvent.
    Type: Application
    Filed: October 6, 2010
    Publication date: January 31, 2013
    Applicant: CIPLA LIMITED
    Inventors: Manjinder Singh Phull, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Patent number: 8288568
    Abstract: The present invention provides a novel process for the preparation of a compound of Formula III, and novel processes for preparing escitalopram using the compound of Formula III.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: October 16, 2012
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Dilip Ramdas Birari, Manjinder Singh Phull