Abstract: Disclosed are systems and methods for synthetic loading of configurable logic devices. In some aspects, a method includes determining computational elements that are available for configuration in a configurable logic hardware device; executing a compilation process to program the available computational elements with a conditionally-enabled configuration and to program one or more load enable trees to enable a load of the conditionally-enabled configuration at the computational elements; configuring a software interface to enable the load of the conditionally-enabled configuration on portions of the computational elements via the one or more load enable trees based on a percentage enablement parameter; and enabling iteration through different percentage enablement parameter values, via the software interface, to cause the load of the conditionally-enabled configuration to be applied to different portions of the computational elements without recompiling the configurable logic hardware device.