Patents by Inventor Manjula Aliminati
Manjula Aliminati has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11836614Abstract: A system and methods are provided for image driven quality control for array based PCR. The system comprises a PCR unit, a reaction array plate, a convolutional neural network (CNN) configured to receive a sequence of images of the reaction array plate in the PCR system, and an output of the CNN coupled to a control for the reaction array plate. The method comprises applying a sequence of images from a plurality of subarrays of the reaction array plate to a plurality of CNNs during operation of the PCR system on the reaction plate array, operating the CNNs to generate failure mode predictions for the reaction plate based on the sequence of images, and coupling an output of the CNNs to one or more of a setting for manufacture of the reaction array plate or to control the PCR system.Type: GrantFiled: August 29, 2019Date of Patent: December 5, 2023Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Yong Chu, Nivedita Majumbar, Manjula Aliminati, Yongzhi Chen, Kevin Papenfuss
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Patent number: 10930373Abstract: A system for analyzing biological data, comprising: a storage configured to store a plurality of data files containing biological data obtained from a plurality of devices; a server configured to: host a plurality of applications, each configured to be implemented on the server and to provide analysis, manipulation, comparison, visualization, or a combination thereof, of the biological data included in the data files, wherein the plurality of applications allow a user to analyze different data files related to the same sample and compare the results of the analysis.Type: GrantFiled: March 24, 2015Date of Patent: February 23, 2021Assignee: Life Technologies CorporationInventors: Nivedita Sumi Majumdar, Harrison Leong, Shakila Pothini, David Hoard, Christopher Fong, Pratik Simon Soares, Salil Kumar, Thomas Wessel, Manjula Aliminati, Levente Egry
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Publication number: 20200074303Abstract: A system and methods are provided for image driven quality control for array based PCR. The system comprises a PCR unit, a reaction array plate, a convolutional neural network (CNN) configured to receive a sequence of images of the reaction array plate in the PCR system, and an output of the CNN coupled to a control for the reaction array plate. The method comprises applying a sequence of images from a plurality of subarrays of the reaction array plate to a plurality of CNNs during operation of the PCR system on the reaction plate array, operating the CNNs to generate failure mode predictions for the reaction plate based on the sequence of images, and coupling an output of the CNNs to one or more of a setting for manufacture of the reaction array plate or to control the PCR system.Type: ApplicationFiled: August 29, 2019Publication date: March 5, 2020Inventors: Yong CHU, Nivedita MAJUMBAR, Manjula ALIMINATI, Yongzhi CHEN, Kevin PAPENFUSS
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Patent number: 10557821Abstract: In one exemplary embodiment, a method for detecting variants in electropherogram data is provided. The method includes receiving electropherogram data from an instrument and analyzing the electropherogram data to identify mixed bases in the electropherogram data. The method further includes validating the identified mixed bases. Then the method includes determining variants in the electropherogram data based on the validated mixed bases.Type: GrantFiled: February 1, 2019Date of Patent: February 11, 2020Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: David Denny, David Woo, Manjula Aliminati, Siva Kumar Samsani, Stephanie Schneider, Yoke Peng Lim, Sylvia Chang
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Publication number: 20200035329Abstract: A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting of emission data from a planiality of samples, each included in a sample region of a plurality of sample regions, at a first time amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data, A dPCR result is generated based on the positive amplification determinations for the plurality of samples.Type: ApplicationFiled: October 1, 2019Publication date: January 30, 2020Applicant: Life Technologies CorporationInventors: Gordon A. Janaway, Manjula Aliminati, Ruoyun Wu, David Fortescue, Ming Shen
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Patent number: 10453557Abstract: A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.Type: GrantFiled: September 28, 2012Date of Patent: October 22, 2019Assignee: Life Technologies CorporationInventors: Gordon A. Janaway, Manjula Aliminati, Ruoyun Wu, David Fortescue, Ming Shen
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Publication number: 20190170684Abstract: In one exemplary embodiment, a method for detecting variants in electropherogram data is provided. The method includes receiving electropherogram data from an instrument and analyzing the electropherogram data to identify mixed bases in the electropherogram data. The method further includes validating the identified mixed bases. Then the method includes determining variants in the electropherogram data based on the validated mixed bases.Type: ApplicationFiled: February 1, 2019Publication date: June 6, 2019Inventors: David DENNY, David WOO, Manjula ALIMINATI, Siva Kumar SAMSANI, Stephanie SCHNEIDER, Yoke Peng LIM, Sylvia CHANG
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Patent number: 10197529Abstract: In one exemplary embodiment, a method for detecting variants in electropherogram data is provided. The method includes receiving electropherogram data from an instrument and analyzing the electropherogram data to identify mixed bases in the electropherogram data. The method further includes identifying features within the electropherogram data indicative of errors and validating the identified mixed bases. Then the method includes determining variants in the electropherogram data based on the validated mixed bases.Type: GrantFiled: April 15, 2016Date of Patent: February 5, 2019Assignee: Life Technologies CorporationInventors: David A. Denny, David Woo, Manjula Aliminati, Siva Kumar Samsani, Stephanie J. Schneider, Yoke Peng Lim, Sylvia Chang
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Publication number: 20170177792Abstract: A system for analyzing biological data, comprising: a storage configured to store a plurality of data files containing biological data obtained from a plurality of devices; a server configured to: host a plurality of applications, each configured to be implemented on the server and to provide analysis, manipulation, comparison, visualization, or a combination thereof, of the biological data included in the data files, wherein the plurality of applications allow a user to analyze different data files related to the same sample and compare the results of the analysis.Type: ApplicationFiled: March 24, 2015Publication date: June 22, 2017Inventors: Nivedita Sumi MAJUMDAR, Harrison LEONG, Shakila POTHINI, David HOARD, Christopher FONG, Pratik Simon SOARES, Salil KUMAR, Thomas WESSEL, Manjula ALIMINATI, Levente EGRY
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Publication number: 20160313280Abstract: In one exemplary embodiment, a method for detecting variants in electropherogram data is provided. The method includes receiving electropherogram data from an instrument and analyzing the electropherogram data to identify mixed bases in the electropherogram data. The method further includes identifying features within the electropherogram data indicative of errors and validating the identified mixed bases. Then the method includes determining variants in the electropherogram data based on the validated mixed bases.Type: ApplicationFiled: April 15, 2016Publication date: October 27, 2016Inventors: David A. Denny, David Woo, Manjula Aliminati, Siva Kumar Samsani, Stephanie J. Schneider, Yoke Peng Lim, Sylvia Chang
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Publication number: 20140236496Abstract: A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.Type: ApplicationFiled: September 28, 2012Publication date: August 21, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Gordon A. Janaway, Manjula Aliminati, Ruoyun Wu, David Fortescue, Ming Shen