Abstract: The present disclosure relates to novel anti-CLEC2D antibodies and related compositions and methods of use thereof. These antibodies are used as therapeutics, and in prognostic and diagnostic applications in various cancers and other diseases.

Abstract: The present disclosure relates to novel anti-CLEC2D antibodies and related compositions and methods of use thereof. These antibodies are used as therapeutics, and in prognostic and diagnostic applications in various cancers and other diseases.

Abstract: The present disclosure relates to vectors for cloning and expressing genetic material including but not limiting to antibody gene or parts thereof and methods of generating said vectors. Said vectors express the antibody genes in different formats such as Fab or scFv as a part of intertransfer system, intratransfer system or direct cloning and expression in individual display systems. In particular, phage display technology is used to clone and screen potential antibody genes in phagemid which is followed by the transfer of said genes to yeast vector for further screening and identification of lead molecules against antigens. The present vectors have numerous advantages including uniquely designed inserts/expression cassettes resulting in efficient and smooth transfer of clonal population from phage to yeast vectors resulting in efficient library preparation and identification of lead molecules.

Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a human naïve antibody gene expression library encompassing a pool of nucleic acid sequences derived from a natural antibody repertoire comprising humoral immunity from healthy and genetically diverse human populations. More specifically, the method employs a combination of phage and/or yeast antibody surface display concept which allows to screen large antibody library size and facilitates better folding of antibody structure. The present disclosure also relates to a human naïve antibody library generated by employing the process of the present disclosure, a set of primers employed in the method and application(s) of said antibody library.

Abstract: The present disclosure relates to methods of obtaining cell with disrupted fucosylation and obtaining afucosylated protein. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology in a protein producing cell line to produce afucosylated protein. The resulting protein, specifically the resulting monoclonal antibody is completely afucosylated and reveals higher degree of antibody dependent cellular cytotoxicity.

Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a synthetic antibody gene expression library built on pool of consensus nucleic acid sequences by using codon replacement technology. The present disclosure also relates to a synthetic antibody library generated by employing the method of the present disclosure and application(s) of said antibody library.

Abstract: The present disclosure relates to novel anti-CLEC2D antibodies and related compositions and methods of use thereof. These antibodies are used as therapeutics, and in prognostic and diagnostic applications in various cancers and other diseases.

Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a human naïve antibody gene expression library encompassing a pool of nucleic acid sequences derived from a natural antibody repertoire comprising humoral immunity from healthy and genetically diverse human populations. More specifically, the method employs a combination of phage and/or yeast antibody surface display concept which allows to screen large antibody library size and facilitates better folding of antibody structure. The present disclosure also relates to a human naïve antibody library generated by employing the process of the present disclosure, a set of primers employed in the method and application(s) of said antibody library.

Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a synthetic antibody gene expression library built on pool of consensus nucleic acid sequences by using codon replacement technology. The present disclosure also relates to a synthetic antibody library generated by employing the method of the present disclosure and application(s) of said antibody library.

Abstract: The present disclosure provides an exhaust diffuser for a gas turbine engine. The exhaust diffuser may include a hub, a casing, and a strut extending between the hub and the casing. The hub may include an angled configuration about the strut and a substantially flat configuration downstream of the angled configuration.

Abstract: The present disclosure relates to vectors for cloning and expressing genetic material including but not limiting to antibody gene or parts thereof and methods of generating said vectors. Said vectors express the antibody genes in different formats such as Fab or scFv as a part of intertransfer system, intratransfer system or direct cloning and expression in individual display systems. In particular, phage display technology is used to clone and screen potential antibody genes in phagemid which is followed by the transfer of said genes to yeast vector for further screening and identification of lead molecules against antigens. The present vectors have numerous advantages including uniquely designed inserts/expression cassettes resulting in efficient and smooth transfer of clonal population from phage to yeast vectors resulting in efficient library preparation and identification of lead molecules.

Abstract: A gas turbine diffuser for use with a gas turbine power system is provided. The diffuser includes an annular inner wall and an annular outer wall circumscribing the inner wall such that a gas path is defined between the inner and outer walls. The diffuser further includes a plurality of circumferentially-spaced struts extending from the inner wall to the outer wall across the gas path. At least one of the struts has a flap.

Abstract: The present disclosure relates to methods of obtaining cell with disrupted fucosylation and obtaining afucosylated protein. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology in a protein producing cell line to produce afucosylated protein. The resulting protein, specifically the resulting monoclonal antibody is completely afucosylated and reveals higher degree of antibody dependent cellular cytotoxicity.

Abstract: The present application provides an exhaust diffuser for a gas turbine engine. The exhaust diffuser may include a hub, a casing, and a strut extending between the hub and the casing. The hub may include an angled configuration about the strut and a substantially flat configuration downstream of the angled configuration.

Abstract: A gas turbine having a seal sealing a trench cavity defined between a stator inboard face and rotor inboard face. The seal may include a stator overhang that extends axially toward the rotor inboard face. The stator overhang may include an overhang topside, an overhang underside, and an overhang face that is defined therebetween. The trench cavity seal may include a platform lip extending axially from the rotor inboard face toward the stator inboard face and circumferentially spaced turbulators extending axially from the rotor inboard face. An outboard edge and an inboard edge of the stator overhang axially jut such that, therebetween, a recessed pocket on the overhang face is formed. The platform lip may radially overlaps the recessed pocket on the overhang face so to form a multiple switch-back flowpath.

Abstract: A gas turbine diffuser for use with a gas turbine power system is provided. The diffuser includes an annular inner wall and an annular outer wall circumscribing the inner wall such that a gas path is defined between the inner and outer walls. The diffuser further includes a plurality of circumferentially-spaced struts extending from the inner wall to the outer wall across the gas path. At least one of the struts has a flap.

Abstract: An exhaust diffuser includes an outer shroud and an inner shroud radially separated from the outer shroud so as to define a fluid passage between the outer shroud and the inner shroud. A strut extends between the outer shroud and the inner shroud. The strut generally includes an outer surface, a leading edge, a trailing edge, a first side and a second side. At least one turbulator may be positioned along a radial span of the strut. The at least one turbulator extends generally outwardly from the strut outer surface. The turbulator extends across the leading edge of the strut from the first side to the second side of the strut.

Abstract: In one embodiment, a method includes receiving at a protocol translator a first message from a first endpoint to a second endpoint. The first message includes a list of media capabilities of the first endpoint. The method also includes transmitting from the protocol translator a second message to the second endpoint including a media capabilities request header and receiving at the protocol translator a response message from the second endpoint. The response message includes a response header including a list of the media capabilities of the second endpoint.

Abstract: In one embodiment, a session is refreshed using a message that is simplified for refresh purposes. The refresh message that is used is a message used for another purpose in a protocol (e.g., SIP). For example, a reINVITE message may be used as a refresh message. If the reINVITE message is used for its intended purpose, the reINVITE message may be used to change the characteristics of a session. This reINVITE message includes an SDP and full header such that the parameters can be properly changed. However, the reINVITE message may be used to refresh a session. This may be referred to as a simple refresh message. But, the simple refresh message does not include an SDP or any other message body. The simple refresh message includes only a reduced header. This reduces time spent building and parsing the simple refresh message.

Abstract: A flow manipulating arrangement for a turbine exhaust diffuser includes a strut having a leading edge and a trailing edge, the strut disposed within the turbine exhaust diffuser. Also included is a plurality of rotatable guide vanes disposed in close proximity to the strut and configured to manipulate an exhaust flow, wherein the plurality of rotatable guide vanes is coaxially aligned and circumferentially arranged relative to each other. Further included is an actuator in operative communication with the plurality of rotatable guide vanes and configured to actuate an adjustment of the plurality of rotatable guide vanes. Yet further included is a circumferential ring operatively coupling the plurality of rotatable guide vanes, wherein the actuator is configured to directly actuate rotation of one of the rotatable guide vanes, and wherein the circumferential ring actuates rotation of the plurality of rotatable guide vanes upon rotational actuation by the actuator.