Patents by Inventor Manjunatha Ramachandra Kini

Manjunatha Ramachandra Kini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides with vasodilatory and/or diuretic functions
    Patent number: 11312758
    Abstract: The present invention relates to peptides with vasodilatory and/or diuretic functions. In particular, the invention relates to modifying key amino acid residues in natriuretic peptides to achieve different functions and properties. Accordingly the invention also includes modified natriuretic peptides. The invention also relates to the use of these peptides for regulating blood pressure-volume and/or treating a heart condition.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: April 26, 2022
    Assignee: National University of Singapore
    Inventors: Manjunatha Ramachandra Kini, Sindhuja Sridharan
  • PEPTIDES WITH VASODILATORY AND/OR DIURETIC FUNCTIONS
    Publication number: 20190211071
    Abstract: The present invention relates to peptides with vasodilatory and/or diuretic functions. In particular, the invention relates to modifying key amino acid residues in natriuretic peptides to achieve different functions and properties. Accordingly the invention also includes modified natriuretic peptides. The invention also relates to the use of these peptides for regulating blood pressure-volume and/or treating a heart condition.
    Type: Application
    Filed: August 18, 2017
    Publication date: July 11, 2019
    Applicant: National University of Singapore
    Inventors: Manjunatha Ramachandra KINI, Sindhuja SRIDHARAN
  • Compositions and methods for inhibiting thrombogenesis
    Patent number: 9745363
    Abstract: The invention is directed to a composition comprising an (one or more) isolated peptide comprising a BF01 peptide, variants of a BF01 peptide and/or mutants of a BF01 peptide. In particular aspects, the composition is a pharmaceutical composition. The composition(s) can be used to inhibit thrombogenesis, selectively inhibit the intrinsic pathway of blood coagulation and selectively inhibit FX1 in an individual in need thereof comprising administering an effective amount of all or a biologically active portion of a BF01 peptide, one or more variants thereof and/or one or more mutants thereof.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: August 29, 2017
    Assignee: National University of Singapore
    Inventors: Wan Chen, Tse Siang Kang, Manjunatha Ramachandra Kini
  • COMPOSITIONS AND METHODS FOR INHIBITING THROMBOGENESIS
    Publication number: 20160152689
    Abstract: The invention is directed to a composition comprising an (one or more) isolated peptide comprising a BF01 peptide, variants of a BF01 peptide and/or mutants of a BF01 peptide. In particular aspects, the composition is a pharmaceutical composition. The composition(s) can be used to inhibit thrombogenesis, selectively inhibit the intrinsic pathway of blood coagulation and selectively inhibit FX1 in an individual in need thereof comprising administering an effective amount of all or a biologically active portion of a BF01 peptide, one or more variants thereof and/or one or more mutants thereof.
    Type: Application
    Filed: July 1, 2014
    Publication date: June 2, 2016
    Inventors: Wan Chen, Tse Siang Kang, Manjunatha Ramachandra Kini
  • THERAPEUTIC USES OF BETA-ANTAGONISTS
    Publication number: 20100062980
    Abstract: Polypeptides derived from Ophiophagus hannah (king cobra) are disclosed together with their use in the treatment of disease, disorder or pathological condition in a patient in need of treatment. The polypeptides disclosed are functionally characterised by their ability to reduce the mammalian heart rate and/or their ?-antagonist activity.
    Type: Application
    Filed: November 26, 2007
    Publication date: March 11, 2010
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Manjunatha Ramachandra Kini, Yuh Fen Pung, Yi Zhun Zhu, Tsun Hon Peter Wong, Prakash Kumar, Nandhakishore Rajagopalan
  • NOVEL SNAKE TOXIN
    Publication number: 20090285825
    Abstract: This invention is in the field of snake venom and the invention provides a novel snake toxin protein and nucleic acids encoding the same. Also, provided are various uses and compositions based on the discovery of the novel snake toxin.
    Type: Application
    Filed: December 22, 2005
    Publication date: November 19, 2009
    Applicant: National University of Singapore
    Inventors: Manjunatha Ramachandra Kini, Yuh Fen Fung, Prakash Pallathadka Kumar, Peter Tsun Hon Wong, Chung Pin Teo