Patents by Inventor Manlio Cristofori

Manlio Cristofori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5252339
    Abstract: Pharmaceutical compositions for oral use, preferably selected from capsules, tablets or sugar coated tablets, coated by an enterosoluble gastroresistant film, containing a lyophilizate consisting of therapeutically effective amounts of a glycosaminoglycan, a thickening substance and surfactants, and process for obtaining them. The compositions make possible the absorption of the orally administered glycosaminoglycans in the duodenum and in the intestine and the consequent performance of their anticoagulant, fibrinolytic, antithrombotic, antiatherosclerotic and antihyperlipoproteinemic properties.
    Type: Grant
    Filed: January 15, 1992
    Date of Patent: October 12, 1993
    Assignee: Alfa Wasserman S.p.A.
    Inventors: Manlio Cristofori, Egidio Marchi, Leone G. Rotini
  • Patent number: 4515809
    Abstract: Derivatives of benzoylphenoxyalkanoic acids corresponding to the formula: ##STR1## wherein: X represents for example a halogen, R.sup.1 and R.sup.2 represent for example alkyl groups, R represents for example an aminoacid; and the salts thereof are new products showing antilipaemic and anticholesterolemic pharmacological activity.
    Type: Grant
    Filed: April 20, 1981
    Date of Patent: May 7, 1985
    Assignee: Alfa Farmaceutici S.p.A.
    Inventors: Valerio Borzatta, Manlio Cristofori, Mauro Morotti, Giuseppe Mascellani
  • Patent number: 4454145
    Abstract: New compounds of general formula ##STR1## and salts therewith of pharmaceutically acceptable acids, wherein R and R.sub.1 independently represent a hydrogen atom or a straight or branched alkyl group having from 1 to 5 carbon atoms, and n is an integer from 4 to 12; and of general formula ##STR2## wherein R'.sub.1 represents a straight or branched alkyl group having from 2 to 4 carbon atoms, W represents hydroxymethyl or the COOM group in which M stands for a hydrogen atom, an alkali metal or an equivalent of an alkali earth metal and n is an integer from 6 to 8. The compounds are useful in treating hyperlipidaemia.
    Type: Grant
    Filed: April 19, 1982
    Date of Patent: June 12, 1984
    Assignee: Alfa Farmaceutici S.p.A.
    Inventors: Manlio Cristofori, Valerio Borzatta, Mauro Morotti
  • Patent number: 4378373
    Abstract: Derivatives of benzoylphenoxyalkanoic acids corresponding to the formula: ##STR1## wherein: X represents for example a halogen, R.sup.1 and R.sup.2 represent for example alkyl groups, R represents for example an aminoacid; and the salts thereof are new products showing antilipaemic and anticholesterolemic pharmacological activity.
    Type: Grant
    Filed: April 20, 1981
    Date of Patent: March 29, 1983
    Assignee: Alfa Farmaceutici S.p.A.
    Inventors: Valerio Borzatta, Manlio Cristofori, Mauro Morotti, Giuseppe Mascellani
  • Patent number: 4340585
    Abstract: A non-toxic anionic resin selected from resins having a polymeric reticulated skeleton of styrenic or acrylic type, inert to the digestive enzymes, having a molecular weight higher than 1000 and containing ionizable amino groups, resins having a cellulosic reticulated skeleton modified by the introduction of free or substituted amino groups and resins having a polysaccharide reticulated skeleton modified by the introduction of free or substituted amino groups. The resin is capable of binding itself permanently to the biliary acids and is salified with an acid corresponding to the general formula: ##STR1## wherein: R' represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, a hydroxyalkyl group having 1 to 3 carbon atoms,R represents a chlorine atom or a group selected from p-chlorobenzoyl, p-bromobenzoyl and p-fluorobenzoyl,W represents a group selected from OH, --N(R"')--CH(R")-(CH.sub.2).sub.n --COOH and O--CH.sub.
    Type: Grant
    Filed: December 11, 1979
    Date of Patent: July 20, 1982
    Assignee: Alfa Farmaceutici, S.p.A.
    Inventors: Valerio Borzatta, Manlio Cristofori, Angelo Brazzi
  • Patent number: 4296125
    Abstract: Derivatives of benzoylphenoxyalkanoic acids corresponding to the formula: ##STR1## wherein: X represents for example a halogen, R.sup.1 and R.sup.2 represent for example alkyl groups, R represents for example an aminoacid; and the salts thereof are new products showing antilipaemic and anticholesterolemic pharmacological activity.
    Type: Grant
    Filed: February 21, 1980
    Date of Patent: October 20, 1981
    Assignee: Alpha Farmaceutici S.p.A.
    Inventors: Valerio Borzatta, Manlio Cristofori, Mauro Morotti, Giuseppe Mascellani