Abstract: Single domain antibodies that bind to Claudin18.2, and chimeric antigen receptors comprising same are provided. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating a disease or disorder are also provided.

Abstract: The present invention provides hypoxia-inducible factor-2? (HIF-2?) as a target in the prevention/treatment of Parkinson's disease (PD). It is the first time to report the target that illustrated mechanisms of iron metabolism in astrocytes, accordingly to confirm the similarities and differences of iron traffic between astrocytes and neurons, leading to indicated the iron source of iron deposition in dopaminergic (DA) neurons and make sure the cause of iron is unevenly distributed in different brain regions, as well as the effects of glias on the role of iron traffic in neurons. It is HIF-2?, regulates the iron traffic in astrocytes. Therefore, not only a new action target HIF-2? is provided for preventing/treating PD iron deposition, but also a brand-new research thought and experimental evidence are provided for the iron transport mechanism of the astrocytes as the high iron source of nerve cells.

Abstract: Disclosed is a high-frequency-tuning sliding electrical contact. The contact includes a tuning ring which is composed of an inner elastic piece, an upper base, an outer elastic piece and a lower base. Pull rods are welded to an upper side face of the upper base, and upper ends of the pull rods are driven to move up and down by a motor, so that the tuning ring slides up and down between the outer sleeve and the inner sleeve along the pull rods. The overall structure of the novel electrical contact is simple, compact and economical. The disclosure reduces joule heat produced by contact resistance and prevents contact surface fusion welding or conductive damage, and is especially suitable for tuning in a small gap range.

Abstract: Disclosed is a high-frequency-tuning sliding electrical contact. The contact includes a tuning ring which is composed of an inner elastic piece, an upper base, an outer elastic piece and a lower base. Pull rods are welded to an upper side face of the upper base, and upper ends of the pull rods are driven to move up and down by a motor, so that the tuning ring slides up and down between the outer sleeve and the inner sleeve along the pull rods. The overall structure of the novel electrical contact is simple, compact and economical. The disclosure reduces joule heat produced by contact resistance and prevents contact surface fusion welding or conductive damage, and is especially suitable for tuning in a small gap range.