Patents by Inventor Manmohan Singh

Manmohan Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OIL-IN-WATER EMULSIONS THAT CONTAIN NUCLEIC ACIDS
    Publication number: 20140212498
    Abstract: This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.
    Type: Application
    Filed: July 6, 2012
    Publication date: July 31, 2014
    Inventors: Luis Brito, Michelle Chan, Andrew Geall, Derek O'Hagan, Manmohan Singh
  • Compact foldable apparatus for ophthalmology
    Publication number: 20140204337
    Abstract: There is a need for robust and portable system, and apparatus for ophthalmology. We propose use of folding apparatus for ocular purposes for the first time. Our system will have a chin-rest (or face-rest or forehead rest) that can be folded so that the ocular device could be transported in a brief-case type casing.
    Type: Application
    Filed: January 18, 2013
    Publication date: July 24, 2014
    Applicant: Netra System, Inc.
    Inventors: Manish Dinkarrao Kulkarni, Manmohan Singh Sidhu
  • Microemulsions with adsorbed macromolecules and microparticles
    Patent number: 8771747
    Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 8, 2014
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Derek O'Hagan, Gary S. Ott, John Donnelly, Jina Kazzaz, Mildred Ugozzoli, Manmohan Singh, John Barackman
  • Microemulsions with adsorbed macromolecules and microparticles
    Patent number: 8734832
    Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.
    Type: Grant
    Filed: September 15, 2012
    Date of Patent: May 27, 2014
    Assignee: Novartis AG
    Inventors: Derek O'Hagan, Gary S. Ott, John Donnelly, Jina Kazzaz, Mildred Ugozzoli, Manmohan Singh, John Barackman
  • COMBINATION VACCINES WITH LOWER DOSES OF ANTIGEN AND/OR ADJUVANT
    Publication number: 20140112950
    Abstract: Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.
    Type: Application
    Filed: March 2, 2012
    Publication date: April 24, 2014
    Inventors: Manmohan Singh, Barbara Baudner, David Skibinski
  • High Density Perforating Gun System Producing Reduced Debris
    Publication number: 20140083283
    Abstract: A perforating system has a perforating module comprising a unitary body of explosive. The explosive is contained within a non-explosive casing, or liner, having formed indentations and a cover thereover. The indentations, which will transform into explosively formed penetrators (EFP's) upon detonation, have a perimeter shape that allows for improved packing density, e.g., a hexagonal perimeter, which results in relatively little “dead space” wherein no perforating penetrators are generated. In operation, the module provides a relatively dense shot pattern and substantially reduced amount of post-detonation debris that could clog the perforations and/or require remedial clean-up or repeat perforation.
    Type: Application
    Filed: September 10, 2012
    Publication date: March 27, 2014
    Applicant: Owen Oil Tools LP
    Inventors: Dan W. Pratt, Manmohan Singh Chawla
  • HIGH HEAT RESISTANT COMPOSITION
    Publication number: 20140024744
    Abstract: The invention relates to a composition that can be used as a coating and that can protect a substrate coated with this composition from high heat. The composition comprises: a polysulfide, an epoxy resin, a compound selected from compounds having a secondary and/or a tertiary amine group, and compounds having an amide group, a polysiloxane, and fibres.
    Type: Application
    Filed: January 20, 2012
    Publication date: January 23, 2014
    Applicant: AKZO NOBEL COATINGS INTERNATIONAL B.V.
    Inventors: Malkit Singh Deogon, Manmohan Singh Deogon
  • ADJUVANT NANOEMULSIONS WITH PHOSPHOLIPIDS
    Publication number: 20140017285
    Abstract: To formulate amphiphilic pharmacological agents (in particular, amphiphilic immunopotentiators) in oil-in-water emulsions the invention provides an oil-in-water emulsion comprising an aqueous phase, an oil phase, a surfactant, and a phospholipid.
    Type: Application
    Filed: March 23, 2012
    Publication date: January 16, 2014
    Applicant: NOVARTIS AG
    Inventors: Luis Brito, Manmohan Singh, Derek O'Hagan
  • SOLUBLE NEEDLE ARRAYS FOR DELIVERY OF INFLUENZA VACCINES
    Publication number: 20130287832
    Abstract: Influenza vaccines are administered using solid biodegradable microneedles. The microneedles are fabricated from the influenza vaccine in combination with solid excipient(s) and, after penetrating the skin, they dissolve in situ and release the vaccine to the immune system. The influenza vaccine is (i) a purified influenza virus surface antigen vaccine, rather than a live vaccine or a whole-virus or split inactivated vaccine (ii) an influenza vaccine prepared from viruses grown in cell culture, not eggs, (iii) a monovalent influenza vaccine e.g. for immunizing against a pandemic strain, (iv) a bivalent vaccine, (v) a tetravalent or >4-valent vaccine, (vi) a mercury-free vaccine, or (vii) a gelatin-free vaccine.
    Type: Application
    Filed: August 19, 2011
    Publication date: October 31, 2013
    Applicants: THERAJECT ,INC., Novartis AG
    Inventors: Derek O'Hagan, Manmohan Singh, Sung-Yun Kwon
  • ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS
    Publication number: 20130274465
    Abstract: Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
    Type: Application
    Filed: September 1, 2011
    Publication date: October 17, 2013
    Applicants: IRM LLC, NOVARTIS AG
    Inventors: Manmohan Singh, David A.G. Skibinski, Tom Yao-Hsiang Wu, Yongkai Li, Alex Cortez, Xiaoyue Zhang, Yefen Zou, Timothy Z. Hoffman, Jianfeng Pan, Kathy Yue
  • CONCENTRATION OF VACCINE ANTIGENS WITH LYOPHILIZATION
    Publication number: 20130243841
    Abstract: A process for preparing a lyophilised vaccine antigen, comprising steps of (i) increasing the concentration of an antigen in a liquid composition including that antigen using centrifugal filtration and/or ultrafiltration, to provide a concentrated antigen, and (ii) lyophilising the concentrated antigen, to provide the lyophilised vaccine antigen. The lyophilised material can be reconstituted and used for vaccine formulation. The process is particularly useful with influenza vaccine antigens.
    Type: Application
    Filed: June 1, 2011
    Publication date: September 19, 2013
    Applicant: Novartis AG
    Inventors: Sushma Kommareddy, Derek O'Hagan, Manmohan Singh, Amanda Scampini Bonificio, Barbara Baudner
  • ADJUVANTED FORMULATIONS OF BOOSTER VACCINES
    Publication number: 20130236492
    Abstract: The invention improves TdaP vaccines by including a TLR agonist in them. This agonist can provide stronger protection, longer-lasting protection, and/or can reduce the amount of antigen which is required to achieve a particular immune response.
    Type: Application
    Filed: March 8, 2013
    Publication date: September 12, 2013
    Applicant: NOVARTIS AG
    Inventors: Barbara BAUDNER, Derek O'HAGAN, Manmohan SINGH, Simone BUFALI
  • Compositions for inducing immune responses
    Patent number: 8529906
    Abstract: The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said first antigen is encapsulated within, adsorbed or conjugated to, co-lyophilized or mixed with said first adjuvant, and a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions, methods for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject, and methods of immunization.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: September 10, 2013
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Derek O'Hagan, Manmohan Singh
  • CONCENTRATION OF VACCINE ANTIGENS WITHOUT LYOPHILIZATION
    Publication number: 20130224245
    Abstract: An antigen concentration procedure does not involve lyophilisation of a bulk antigen before its final formulation and/or delivery. Thus a process for preparing a vaccine comprises steps of (i) increasing the concentration of an antigen in a liquid composition including that antigen, to provide a concentrated antigen, and (ii) formulating a vaccine from the concentrated antigen. The concentrated antigen is not lyophilised between or during steps (i) and (ii). The invention is particularly useful for preparing solid vaccine forms.
    Type: Application
    Filed: June 1, 2011
    Publication date: August 29, 2013
    Applicant: Novartis AG
    Inventors: Sushma Kommareddy, Derek O'Hagan, Manmohan Singh, Amanda Bonoficio, Barbara Baudner
  • MICROEMULSIONS WITH ADSORBED MACROMOLECULES AND MICROPARTICLES
    Publication number: 20130195898
    Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.
    Type: Application
    Filed: September 15, 2012
    Publication date: August 1, 2013
    Applicant: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Derek O'Hagan, Gary S. Ott, John Donnelly, Jina Kazzaz, Mildred Ugozzoli, Manmohan Singh, John Barackman
  • MICROEMULSIONS WITH ADSORBED MACROMOLECULES AND MICROPARTICLES
    Publication number: 20130195923
    Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: August 1, 2013
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS, INC.
    Inventors: Derek O'Hagan, Gary S. Ott, John Donnelly, Jina Kazzaz, Mildred Ugozzoli, Manmohan Singh, John Barackman
  • VIRION-LIKE DELIVERY PARTICLES FOR SELF-REPLICATING RNA MOLECULES
    Publication number: 20130195968
    Abstract: Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non-virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases.
    Type: Application
    Filed: July 6, 2011
    Publication date: August 1, 2013
    Applicant: Novartis AG
    Inventors: Andrew Geall, Christian Mandl, Derek O'Hagan, Manmohan Singh
  • DELIVERY OF SELF-REPLICATING RNA USING BIODEGRADABLE POLYMER PARTICLES
    Publication number: 20130183355
    Abstract: Particle compositions comprising adsorbed RNA replicons as well as methods of making and using the same are described.
    Type: Application
    Filed: June 7, 2011
    Publication date: July 18, 2013
    Applicant: NOVARTIS AG
    Inventors: Siddhartha Jain, Derek O'Hagan, Manmohan Singh
  • Compounds and compositions as TLR activity modulators
    Patent number: 8466167
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4?CR5.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: June 18, 2013
    Assignees: IRM LLC, Novartis AG
    Inventors: Tom Yao Hsiang Wu, Yongkai Li, Alex Cortez, Yefen Zou, Pranab Mishra, Xiaoyue Zhang, David Skibinski, Manmohan Singh, Nicholas Valiante
  • Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
    Patent number: 8431160
    Abstract: Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adjuvant and a combination thereof. Also described are methods of making such compositions and methods of administering such compositions. Methods of modulating the release rate of immunological species from microparticles are also described. These methods comprise varying the ratio of the cationic polysaccharide relative to the biodegradable polymer within the microparticles.
    Type: Grant
    Filed: February 24, 2007
    Date of Patent: April 30, 2013
    Assignee: Novartis AG
    Inventors: Derek O'Hagan, Manmohan Singh, Janet Wendorf, Jina Kazzaz, Padma Malyala